Open Access

ARTICLE

Role of Tissue Structure on Ventricular Wall Mechanics

Benjamin A. Coppola^*, Jeffrey H. Omens^∗,†

* Departments of Bioengineering, University of California, San Diego, La Jolla, CA 92093.
† Corresponding author. Departments of Medicine, University of California, San Diego, La Jolla, CA 92093. jomens@ucsd.edu; 9500 Gilman Dr. Mail Code 0613J, La Jolla, California 92093.

Molecular & Cellular Biomechanics 2008, 5(3), 183-196. https://doi.org/10.3970/mcb.2008.005.183

Abstract

It is well known that systolic wall thickening in the inner half of the left ventricular (LV) wall is of greater magnitude than predicted by myofiber contraction alone. Previous studies have related the deformation of the LV wall to the orientation of the laminar architecture. Using this method, wall thickening can be interpreted as the sum of contributions due to extension, thickening, and shearing of the laminar sheets. We hypothesized that the thickening mechanics of the ventricular wall are determined by the structural organization of the underlying tissue, and may not be influenced by factors such as loading and activation sequence. To test this hypothesis, we calculated finite strains from biplane cineradiography of transmural markers implanted in apical (n = 22) and basal (n = 12) regions of the canine anterior LV free wall. Strains were referred to three-dimensional laminar microstructural axes measured by histology. The results indicate that sheet angle is of opposite sign in the apical and basal regions, but absolute value differs only in the subepicardium. During systole, shearing and extension of the laminae contribute the most to wall thickening, accounting for$>$90{\%} (transmural average) at both apex and base. These two types of deformation are also most prominent during diastolic inflation. Increasing afterload has no effect on the pattern of systolic wall thickening, nor does reversing transmural activation sequence. The pattern of wall thickening appears to be a function of the orientation of the laminar sheets, which vary regionally and transmurally. Thus, acute interventions do not appear to alter the contributions of the laminae to wall thickening, providing further evidence that the structural architecture of the ventricular wall is the dominant factor for its regional mechanical function.

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