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Inflation of An Artery Leading to Aneurysm Formation and Rupture

J. S. Ren*
* Department of Mechanics, Shanghai institute of applied MathematicsandMechanics,ShanghaiUniversity, Shanghai 200444, China

Molecular & Cellular Biomechanics 2007, 4(1), 55-66. https://doi.org/10.3970/mcb.2007.004.055

Abstract

Formation and rupture of aneurysms due to the inflation of an artery with collagen fibers distributed in two preferred directions, subjected to internal pressure and axial stretch are examined within the framework of nonlinear elasticity. A two layer tube model with a fiber-reinforced composite based incompressible anisotropic hyperelastic constitutive material is employed to model the stress-strain behavior of the artery wall with distributed collagen fibers. The artery wall takes up a uniform inflation deformation, and there are no aneurysms in the artery under the normal condition. But an aneurysm may be formed in arteries when the stiffness of the fibers is decreased to a certain value or the direction of the fibers is changed to a certain degree towards the circumferential direction. The aneurysm may expand to much large extent and become complex in shape. One portion of the aneurysm becomes highly distended as a bubble while the rest remains lightly inflated. The rupture of the aneurysm is discussed along with the distribution of stresses. Critical pressures and the rupture pressures are given for different collagen fiber orientations or stiffness. Furthermore, the stability of the solutions is discussed to explain the formation of aneurysm.

Keywords

artery, collagen fibers, aneurysm, incompressible anisotropic hyperelastic material, stress distribution, material instability

Cite This Article

Ren, J. S. (2007). Inflation of An Artery Leading to Aneurysm Formation and Rupture. Molecular & Cellular Biomechanics, 4(1), 55–66.



This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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