Open Access

ARTICLE

Measurement of Myopia and Normal Human Choroidal Thickness Using Spectral Domain Optical Coherence Tomography

Jia Qin^1,2,3,4,5, Lin An^1,2,3,4,5,*

1 Innovation and Entrepreneurship Teams Project of Guangdong Provincial Pearl River Talents Program Guangdong Weiren Meditech Co., Ltd., Foshan, 528000, China
2 School of Medical Imaging, Weifang Medical University, Weifang, 261053, China
3 School of Physics and Optoelectronic Engineering, Foshan University, Foshan, 528225, China
4 Weiren Medical Care (Foshan) Co., Ltd., Foshan, 528200, China
5 Weizhi Meditech (Foshan) Co., Ltd., Foshan, 528200, China

* Corresponding Author: Lin An. Email:

Molecular & Cellular Biomechanics 2022, 19(3), 151-157. https://doi.org/10.32604/mcb.2022.018578

Received 03 August 2021; Accepted 16 September 2021; Issue published 14 June 2022

Abstract

Myopia is a common ophthalmic deficiency. The structure and function of choroid layer is assumed to be associated with myopia. In this study, a laboratory developed spectral domain optical coherence tomography scanning system is used to image human eyes. The axial resolution of the system is about 7 μm, and the acquisition rate is 100 kHz. Firstly, a cross-sectional image was acquired by averaging 100 images from imaging posterior segment of each eye. The choroid thickness was measured by 11 discrete points. The average thickness of normal human eyes was (0.296 ± 0.126) mm, whereas the average choroid thickness of myopic eyes was (0.220 ± 0.095) mm. Afterwards, the T test is used to calculate the data statistically. The analysis of the final result is based on the average thickness measured and the thickness of each measuring point. There was a significant difference in choroid thickness between myopia and normal eyes (P value < 0.01), which indicates that the choroid thickness of myopia was significantly thinner than that of normal eyes. Besides, there are findings that the choroidal thickness in nasal side is thinner than that in the fovea and temporal side in each eye. The choroidal thickness on temporal side in myopia eye has the most significant difference comparing with that in normal eye. The comprehensive evaluation of myopia and normal choroidal thickness using spectral domain optical coherence tomography may provide an important reference for the development of medical methods for diagnosis and treatment of myopia.

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Keywords

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