Home / Journals / MCB / Vol.18, No.1, 2021
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  • Open AccessOpen Access

    ARTICLE

    Computational Fluid Dynamics Simulations at Micro-Scale Stenosis for Microfluidic Thrombosis Model Characterization

    Yunduo Charles Zhao1,2,#, Parham Vatankhah1,#, Tiffany Goh1,2,3, Jiaqiu Wang4, Xuanyi Valeria Chen1, Moein Navvab Kashani5,6, Keke Zheng7, Zhiyong Li4, Lining Arnold Ju1,2,3,*
    Molecular & Cellular Biomechanics, Vol.18, No.1, pp. 1-10, 2021, DOI:10.32604/mcb.2021.012598
    Abstract Platelet aggregation plays a central role in pathological thrombosis, preventing healthy physiological blood flow within the circulatory system. For decades, it was believed that platelet aggregation was primarily driven by soluble agonists such as thrombin, adenosine diphosphate and thromboxane A2. However, recent experimental findings have unveiled an intriguing but complementary biomechanical mechanism—the shear rate gradients generated from flow disturbance occurring at sites of blood vessel narrowing, otherwise known as stenosis, may rapidly trigger platelet recruitment and subsequent aggregation. In our Nature Materials 2019 paper [1], we employed microfluidic devices which incorporated micro-scale stenoses to elucidate the molecular insights underlying the… More >

  • Open AccessOpen Access

    ARTICLE

    Cyclic Stretch Induces Inflammatory Cytokines via the Oxidative Stress and NF-ΚB Pathways Activation in Human Keratoconic Fibroblasts

    Xiaona Li1,*, Sijia Wang1, Jie Song1, Yixian Qin2, Jizhong Yang3, Rui He4,*, Weiyi Chen1
    Molecular & Cellular Biomechanics, Vol.18, No.1, pp. 11-19, 2021, DOI:10.32604/mcb.2021.014071
    Abstract The cornea is a load-bearing tissue. Lower biomechanical properties in the local tissue of keratoconic cornea evoke mechanical stress increase. Inflammatory cytokines have been shown to be over-expressed in patients with keratoconus. However, how mechanical stimuli are involved in the production of inflammatory cytokines in keratoconus remains unclear. The objective of the study is to determine the role of mechanical stretch in the regulation of inflammatory cytokines and the underlying mechanisms in keratoconus. Human keratoconic fibroblasts (hKCFs) were subjected to 12% cyclic mechanical stretch at 0.1 Hz or in static conditions as controls. N-acetyl cysteine (NAC) and pyrrolidine dithiocarbamate and… More >

  • Open AccessOpen Access

    ARTICLE

    Impact of Temperature on Upper Respiratory Tract Infections in Lanzhou Based on the Distributed Lag Model

    Guangyu Zhai1,2, Kuan Zhang2, Guorong Chai1,*
    Molecular & Cellular Biomechanics, Vol.18, No.1, pp. 21-31, 2021, DOI:10.32604/mcb.2021.014287
    Abstract The study mainly analyzed the relationship between temperature and the upper respiratory tract infections (URI) in Lanzhou. We collected the daily URI and meteorological data from 2010 to 2015. A distributed lag non-linear model was used to examine the relationship and potential effects of different temperatures and different lag days on the morbidity of URI. The results showed that the morbidity of URI was significantly related to the meteorological factors, and the peak of the onset of the disease usually occurred between November and February the next year. The correlation analysis was carried out between meteorological factors and URI cases,… More >

  • Open AccessOpen Access

    ARTICLE

    Characteristics of Surface Electromyography of Forehand Smash of Badminton Players

    Chen Zhang*
    Molecular & Cellular Biomechanics, Vol.18, No.1, pp. 33-40, 2021, DOI:10.32604/mcb.2021.014352
    Abstract To understand the characteristics of the forehand smash of badminton player and improve their performance, this study took eight badminton players as the subject, obtained the kinematics data through the Qualisys infrared high-speed camera, obtained the electromyography (EMG) data through the ME-6000 surface EMG test system, and compared and analyzed their forehand smash action. The results showed that the greater the angle and speed of different joints in the forehand smash was, the greater the speed and strength of hitting the ball was; the discharge amount of biceps brachii (BB) was the smallest, followed by triceps brachii (TB), flexor carpi… More >

  • Open AccessOpen Access

    ARTICLE

    Biomechanical Properties of Multi-Swing and Single-Swing Rope Skipping Actions

    Yiran Tian*
    Molecular & Cellular Biomechanics, Vol.18, No.1, pp. 41-49, 2021, DOI:10.32604/mcb.2021.014394
    Abstract Rope skipping is popular as it is easy to learn; thus, it has developed into a competitive sport. The research on the biomechanical properties of rope skipping can effectively improve training efficiency and reduce injury probability. This paper briefly introduced the characteristics of single-swing and multi-swing techniques in competitive rope skipping, selected ten second-grade athletes as the subjects to test the single-swing and triple-swing rope skipping, and tested the biomechanical properties in the process of rope skipping. The results showed that the variation range of the lower limb joint angle in the triple-swing rope skipping was larger than that in… More >

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