Open Access
ARTICLE
Hui Yao1, Liqun Wang3, Jia Guo1, Weimin Liu4, Jingjing Li1, Yingxiao Wang2, Linhong Deng1,*, Mingxing Ouyang1,2,3,*
Molecular & Cellular Biomechanics, Vol.17, No.3, pp. 101-111, 2020, DOI:10.32604/mcb.2020.09595
Abstract Prostate cancer is the most common cancer among men beyond 50 years
old, and ranked the second in mortality. The level of Prostate-specific antigen
(PSA) in serum has been a routine biomarker for clinical assessment of the cancer
development, which is detected mostly by antibody-based immunoassays. The
proteolytic activity of PSA also has important functions. Here a genetically
encoded biosensor based on fluorescence resonance energy transfer (FRET) technology was developed to measure PSA activity. In vitro assay showed that the
biosensor containing a substrate peptide ‘RLSSYYSGAG’ had 400% FRET
change in response to 1 µg/ml PSA within 90 min, and… More >
Open Access
ARTICLE
Phuong-Thao Nguyen-Thi1, Quoc Phong Le1, Volker R. Stoldt2, Ngoc Quyen Tran3,4, Anh Tho Le5, Khon Huynh1,*
Molecular & Cellular Biomechanics, Vol.17, No.3, pp. 113-118, 2020, DOI:10.32604/mcb.2020.09643
Abstract Fibrillar fibronectin (FFN) is a biological active form of FN which form
linear and branched meshwork around cells and support cellular activities. Previous studies have demonstrated that shear stress can induce cell-free FN fibrillogenesis. In this study, we further examined the effect of shear stress conditions on
morphology of formed FFN and preliminarily looked for relationship between
FFN’s morphology and cell adhesion. Plasma FN at 50 µg/ml was perfused
through channel slides at shear rates of 500 s-1 or 4000 s-1. Our results showed
that there were four FFN structures formed: (1) FN nodules, (2) fibril in different
sizes (3)… More >
Open Access
ARTICLE
Qi Li1,2, Ningli Wang3, Zhicheng Liu1,2, Lin Li1,2, Zhicheng Liu1,2, Wenjia Wang1,2, Xiaoxue Long1,2, Hongfang Song1,2,*
Molecular & Cellular Biomechanics, Vol.17, No.3, pp. 119-137, 2020, DOI:10.32604/mcb.2020.09529
Abstract Aim: To investigate the relationship between glaucoma and intraocular
pressure (IOP), intracranial pressure (ICP), trans-laminar cribrosa pressure difference (TLCPD), and the newly proposed fractional pressure reserve (FPR). Methods: Ten articles were analyzed by meta-analysis, and subgroup analysis of three
factors was conducted. Results: The patients with normal tension glaucoma
(NTG) and open-angle glaucoma (OAG) have higher TLCPD and lower ICP than
healthy subjects, with obvious heterogeneity. The greater heterogeneity may arise
from different ICP measurements and from different countries or regions. FPR
performs better than TLCPD in some ways. Conclusion: Both FPR and TLCPD
can be used as indicators of… More >
Open Access
ARTICLE
Xiaozhong Chen*
Molecular & Cellular Biomechanics, Vol.17, No.3, pp. 139-153, 2020, DOI:10.32604/mcb.2020.08933
Abstract Existing model registration of individual bones does not have a high
certainly of success due to the lack of anatomic semantic. In light of the surface
anatomy and functional structure of bones, we hypothesized individual femur
models would be aligned through feature points both in geometrical level and
in anatomic level, and proposed a hierarchical approach for the rigid registration
(HRR) of point cloud models of femur with high resolution. Firstly, a coarse
registration between two simplified point cloud models was implemented based
on the extraction of geometric feature points (GFPs); and then, according to the
anatomic feature points (AFPs)… More >
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