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Shicheng He¹, Juhui Qiu¹, Wanling Liu¹, Tieying Yin¹, Dechuan Zhang^2,*, Donghua Liao^3,4, Haijun Zhang⁵, Yuxia Yin⁵, Guixue Wang^1,*
Molecular & Cellular Biomechanics, Vol.17, No.2, pp. 63-74, 2020, DOI:10.32604/mcb.2020.08750
Abstract Computational fluid dynamics (CFD) has been widely used for studying intracranial aneurysm hemodynamics, while its use for guiding clinical strategy is still in development. In this study, CFD simulations helped inform treatment decision for a middle cerebral artery (MCA) aneurysm case was investigated. A patient with a 10.4 × 9.8 mm aneurysm attached with a small aneurysm at the edge of the trifurcation in the left MCA was included in this study. For removing the MCA aneurysm, two scenarios were considered: Plan-A involved clipping the small aneurysm and Plan-B involved clipping the whole aneurysm. A… More >

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Ali E. Dabiri^1,2,*, Erik Samwel³, Ghassan S. Kassab¹
Molecular & Cellular Biomechanics, Vol.17, No.2, pp. 75-83, 2020, DOI:10.32604/mcb.2020.08775
Abstract Nearly two billion people are afflicted with iron deficiency and approximately 300 million children globally have anemia. Most of those affected are unaware of their lack of iron, in part because detection of iron deficiency requires a blood test. It is becoming increasingly important to screen these individuals to reduce medical cost and avoid chronic disease conditions. There are limited settings of laboratory infrastructure for standard blood-based tests around the world to routinely accomplish this important screening test. We propose a new concept to use either human hair or nail as a screening method to… More >

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Lujie Chen¹, Liang Zheng¹, Maosen Lian¹, Shouhua Luo^1,*
Molecular & Cellular Biomechanics, Vol.17, No.2, pp. 85-92, 2020, DOI:10.32604/mcb.2019.07386
Abstract Micro-CT provides a high-resolution 3D imaging of micro-architecture in a non-invasive way, which becomes a significant tool in biomedical research and preclinical applications. Due to the limited power of micro-focus X-ray tube, photon starving occurs and noise is inevitable for the projection images, resulting in the degradation of spatial resolution, contrast and image details. In this paper, we propose a C-GAN (Conditional Generative Adversarial Nets) denoising algorithm in projection domain for Micro-CT imaging. The noise statistic property is utilized directly and a novel variance loss is developed to suppress the blurry effects during denoising procedure.… More >

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Rafi Mazor^1,*, Meital Mazor², Ali E. Dabiri^2,3, Bhavesh Patel², Ghassan S. Kassab²
Molecular & Cellular Biomechanics, Vol.17, No.2, pp. 93-99, 2020, DOI:10.32604/mcb.2019.08267
Abstract Cryotherapy, or more commonly known as cold therapy, is the use of low temperatures in medical treatment. The most prominent use of cryotherapy is for cryosurgery where application of very low temperatures is used to ablate diseased tissue (e.g., most commonly in dermatology). Recent research, however, shows that low temperature may modulate collagen fibers beyond the already known effects of extreme cooling on joint pain relieve and inflammation. The goal of this brief review is to outline the known effects of extreme cooling on molecular, fiber and cell physiology and to leverage these properties in… More >

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