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ABSTRACT

Danyang Yue¹, Yijuan Fan¹, Juan Lu¹, Mengxue Zhang¹, Jin Zhou¹, Yuying Bai¹, Jun Pan^1,*
Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 144-144, 2019, DOI:10.32604/mcb.2019.07084
Abstract Mesenchymal Stem Cells (MSCs) are recruited to the musculoskeletal system following trauma [1] or chemicals stimulation [2]. The regulation of their differentiation into either bone or cartilage cells is a key question. The fluid shear stress (FSS) is of pivotal importance to the development, function and even the repair of all tissues in the musculoskeletal system [3]. We previously found that MSCs are sensitive enough to distinguish a slight change of FSS stimulation during their differentiation commitment to bone or cartilage cells, and the internal mechanisms. In detail, MSCs were exposed to laminar FSS linearly increased from 0 to 10… More >

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ABSTRACT

Zongkun Hou¹, Shilei Hao¹, Bochu Wang^1,*
Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 145-145, 2019, DOI:10.32604/mcb.2019.07077
Abstract An expansion of the cerebral neocortex is thought to be the foundation for the unique intellectual abilities of humans. The cortical folding has been implicated in neurodevelopmental disorders and yet its origins remain unknown. In vitro culture of 3D cerebral organoids from human pluripotent stem cells has been used to study the fundamental mechanisms of mammalian neurodevelopment and characteristics of human brain development. Here, we explores the mechanism of boundary limitation on the formation of gyri and sulci through the self-organization of human brain organoids. The structure of cerebral organoids was analyzed by morphology observation, pathology and immunofluorescence. The different… More >

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ABSTRACT

Qi Dang¹, Chun-Gong Li¹, Xin-Xin Jin¹, Ya-Jin Zhao¹, Xiang Wang^1,*
Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 146-146, 2019, DOI:10.32604/mcb.2019.07074
Abstract Endotoxin is a a very powerful and toxic inflammatory stimulator usually leading to the sepsis occurred. In order to remove endotoxin better through hemoperfusion, it is a pretty choice to increase the length of molecular linker on adsorbents. In this study, we chose the heparin as a molecular linker because of its being anticoagulant linear polysaccharide. Heparin as a linker was covalently immobilized on the chloromethylated polystyrene microspheres (Ps) and then connected with L-phenylalanine (Phe) forming the Ps-Hep-Phe structure to adsorbed endotoxin better. The property of microspheres was characterized by Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, zeta potential and… More >

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1252

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Ying Li¹, Bin Xue², Wenxu Sun², Junhua Wu², Wenting Yu², Meng Qin², Wei Wang², Yi Cao^2,*
Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 147-147, 2019, DOI:10.32604/mcb.2019.07027
Abstract A key challenge in biomaterials research is to produce synthetic hydrogels that can replicate the diverse mechanical properties of the naturally occurring tissues for various biomedical applications, including tissue engineering, stem cell and cancer research, cell therapy, and immunomodulation. However, currently, the methods that can be used to control the mechanical properties of hydrogels are very limited and are mainly focused only on the elasticity of hydrogels. In this work, combining single molecule force spectroscopy, protein engineering and theoretical modeling, we show that synthetic protein hydrogels with predictable mechanical properties can be rationally designed using protein building blocks with known… More >

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Stamatia Pagoulatou^1,*, Mauro Ferraro¹, Bram Trachet^1,2, Georgios Rovas¹, Vasiliki Bikia¹, Dionysios Adamopoulos³, Lindsey Crowe³, Jean-Paul Vallée³, Nikolaos Stergiopulos¹
Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 148-149, 2019, DOI:10.32604/mcb.2019.07346
Abstract This article has no abstract. More >

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1304

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Dong Chen¹, Xiang Wang^1,*, Fuzhou Tang², Yajin Zhao¹
Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 150-150, 2019, DOI:10.32604/mcb.2019.07071
Abstract Deformability is a fundamental property of the cells and tissues of living organisms, which is commonly detected to indicate the state of the cells. And the cell deformability usually depends on the methods that we used, which is easy to be confused. The present research is designed to explore the energy characteristic of red blood cell deformability, based on a quantitative analysis of extending-retracting curves acquired from atomic force microscopy. ATP-depleted red blood cells are prepared by treatment with free-glucose Ringer solution. Our results clearly show that the Youngs’ modulus of erythrocyte is closely depended on the concentration of intracellular… More >

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