Open Access

ABSTRACT

Fast Force Loading Disrupts Molecular Bond Stability in Human and Mouse Cell Adhesions

Yunfeng Chen^1,2,3,†,*, Jiexi Liao^4,†, Zhou Yuan¹, Kaitao Li⁴, Baoyu Liu⁴, Lining Arnold Ju^4,5,6, Cheng Zhu^1,2,4,5,*

1 Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia, 30332, USA.
2 Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, Georgia 30332, USA;
3 Department of Molecular Medicine, MERU-Roon Research Center on Vascular Biology, The Scripps Research Institute, La Jolla, California 92037, USA;
4 Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA;
5 Heart Research Institute, The University of Sydney, Camperdown, NSW 2006, Australia.
6 Charles Perkins Centre, The University of Sydney, Camperdown, NSW 2006, Australia.
† These authors contribute equally.
* Corresponding Authors: Yunfeng Chen. Email: cheny@scripps.edu; Cheng Zhu. Email: cheng.zhu@bme.gatech.edu.