Open Access

ABSTRACT

Numerical Analysis of Motion and Stress Distribution of Circulating Tumor Cells in Micro Vessels

Peng Jing¹, Xiaolong Wang¹, Shigeho Noda², Xiaobo Gong^1,*
1 Key Laboratory of Hydrodynamics (Ministry of Education), Department of Engineering Mechanics, School of Naval Architecture, Ocean and Civil Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.
2 Information Systems Division, RIKEN, 2-1, Hirosawa Wako-shi, Saitama, 351-0198, Japan.
* Corresponding Author: Xiaobo Gong. Email: x.gong@sjtu.edu.cn.

Molecular & Cellular Biomechanics 2019, 16(Suppl.2), 36-37. https://doi.org/10.32604/mcb.2019.07111

Abstract

The motion of circulating tumor cells (CTCs) in microcirculatory system is one of the critical steps during cancer metastasis. The moving behavior and stress distribution of circulating tumor cells under different geometry and flow conditions are important basis for studying the adhesion between circulating tumor cells and vessel walls. In the present work, the motion and deformation of circulating tumor cells in capillary tubes are numerically studied using the immersed boundary method (IBM). The membrane stress distribution of CTCs in confined tubes are investigated with under vessel diameters, hematocrit (Ht) values and capillary numbers (Ca). The results show that the vessel diameter, Ca and Ht has profound effects on membrane stress of CTCs.

---

Keywords

Immersed boundary method; fluid-membrane interaction; circulating tumor cell; hemodynamics

---