Open Access
ABSTRACT
Shu Chien
Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 1-2, 2019, DOI:10.32604/mcb.2019.07695
Abstract Professor Y.C. Fung has made tremendous impacts on science, engineering and humanity through his research and its applications, educating many students and their students, and providing his exemplary leadership [1-3]. He has applied his profound knowledge and elegant analytical methods to the study of biomedical problems with rigor and excellence. He established the basic principles of biomechanics in living tissues and organs. He opened up new vista for bioengineering, from organs-systems to molecules-genes, and he has provided the foundation of research activities in many institutions in the United States and the world. He has made outstanding contributions to education in… More >
Open Access
ABSTRACT
Savio L-Y. Woo1,*, Peter C-Y Chen2
Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 1-2, 2019, DOI:10.32604/mcb.2019.07631
Abstract This article has no abstract. More >
Open Access
ABSTRACT
J.D. Humphrey1,*
Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 3-4, 2019, DOI:10.32604/mcb.2019.07639
Abstract This article has no abstract. More >
Open Access
ABSTRACT
Shu Q. Liu1,*
Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 5-7, 2019, DOI:10.32604/mcb.2019.06960
Abstract This article has no abstract. More >
Open Access
ABSTRACT
Erik B. Kistler1, Geert W. Schmid-Schönbein2,*
Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 8-8, 2019, DOI:10.32604/mcb.2019.07256
Abstract A longstanding question in research on organ failure after physiological shock (such as trauma, burns, sepsis, surgery and medical emergencies) is the underlying mechanism for a progressive loss of cell and tissue functions. Our systematic analysis of this problem has served to identify digestive enzymes as key players [1, 2]. After synthesis and discharge from the pancreas, the digestive enzymes are usually contained inside the lumen of the small intestine where they break down food every day. Escape of the digestive enzymes out of the lumen of the intestine is kept to a minimum by the mucosal barrier in the… More >
Open Access
ABSTRACT
William Leineweber1, Stephanie I. Fraley1,2,*
Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 9-9, 2019, DOI:10.32604/mcb.2019.08504
Abstract Cell-extracellular matrix (ECM) interactions are critical modulators of repair and regeneration. However, variability within individual cells of the same cell type and within the ECM microenvironment can lead to heterogeneous outcomes that may limit the reliable application of cell-biomaterial constructs in regenerative medicine. Understanding the origins of heterogeneity is critical to overcoming this challenge and requires measurement of cell-ECM interactions at the single cell level. There are four core biophysical modules that cells employ to interact with their surrounding ECM: protrusion, adhesion, contractility, and matrix remodeling. Conventional approaches measure these interactions in separate experiments on separate cells, resulting in bulk… More >
Open Access
ABSTRACT
Guixue Wang1,*, Li Yang1
Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 10-10, 2019, DOI:10.32604/mcb.2019.08410
Abstract The biomechanics research of Chongqing University (CQU) began in the late 1970s, which has always been guided and helped by Prof. YC Fung. Prof. YP Wu, Prof. GR Wang at CQU were two of the earliest four Chinese scholars to visit and study in Fung's laboratory in the United States. In the autumn of 1979, Fung held a biomechanical workshop in CQU and the former Huazhong Institute of Technology. With the help of him, Prof. YP Wu founded the first Biomechanics Research Lab in China in the late 1970s. The first program for master’s degree on biomechanics was approved to… More >
Open Access
ABSTRACT
Cheng Zhu1,*
Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 11-11, 2019, DOI:10.32604/mcb.2019.08411
Abstract The immune response is orchestrated by a variety of immune cells. The function of each cell is determined by the collective signals from various immunoreceptors whose expression and activity depend on the developmental stages of the cell and its environmental context. Recent studies have highlighted the presence of mechanical forces on specific immunoreceptor–ligand bonds, which are transmitted across the cell membrane, potentially inducing mechanotransduction. As mechanobiology intersects with immunology, the interest to explore how immune cells sense, respond and adapt to their mechanical environment is rapidly growing. In this talk, I will review recent advances in the emerging field of… More >
Open Access
ABSTRACT
Ram P. Ghosh1, Matteo Bianchi1, Gil Marom2, Oren M. Rotman1, Brandon Kovarovic1, Danny Bluestein1,*
Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 12-14, 2019, DOI:10.32604/mcb.2019.07379
Abstract This article has no abstract. More >
Open Access
ABSTRACT
Gloria B. Kim1,†, Qiong Wei2,†, Virginia Aragon-Sanabria1, Sulin Zhang2, Jian Yang1, Cheng Dong1,*
Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 15-15, 2019, DOI:10.32604/mcb.2019.07137
Abstract Most cells survive and grow by attaching and spreading on a substrate. They generate internal tension that contracts the cell body and thus exert tractions on the underlying substrate through focal adhesions. Traction force also plays a critical role in many biological processes, such as inflammation, metastasis, and angiogenesis. Thus, measuring the cell traction force provides valuable information on understanding the underlying mechanism of these biological processes. Here, a traction force microscopy (TFM) method using super thin hydrogels composed of immobilized fluorescent beads was utilized to quantify the mechanical forces generated during the transmigration of Jurkat cells (a human T… More >
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