Open Access

ABSTRACT

Comparison of Aortic Flow Patterns in Patients with and without Aortic Valve Disease: Hemodynamic Simulation Based on PC-MRI and CTA Data

Lijian Xu^1,2, Lekang Yin³, Fuyou Liang^1,2,*

1 School of Naval Architecture, Ocean and Civil Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.
2 Collaborative Innovation Center for Advanced Ship and Deep-Sea Exploration (CISSE), Shanghai Jiao Tong University, Shanghai, 200240, China.
3 Department of Radiology, Shanghai Chest Hospital, Shanghai, 200030, China.
* Corresponding Author: Fuyou Liang. Email: fuyouliang@sjtu.edu.cn.

Molecular & Cellular Biomechanics 2019, 16(Suppl.1), 71-72. https://doi.org/10.32604/mcb.2019.05741

Abstract

Recent studies have revealed that aortic valve diseases are associated with the increased incidence of the aortopathy development. However, the influence of aortic valve diseases on aortic hemodynamics remains unclear. The purpose of this study was therefore to investigate the hemodynamic differences in patients with and without aortic valve disease through patient-specific simulations performed on two aorta models (BAV with severe stenosis vs. normal tricuspid aortic valve (TAV)). Realistic geometries and boundary conditions were obtained from computed tomography angiography (CTA) and phase-contrast magnetic resonance imaging (PC-MRI) measurements, respectively. In addition, 4D-MRI were performed to validate the numerical methods used to simulate transient flow characteristics. Obtained results shown that the 3D streamlines in the patient with normal TAV were relatively symmetric and evenly distributed. For the patient with BAV, concentrated and high-speed inflow jets were found to impinge on the ascending aorta accompanied by strong vortices. These results indicate that the aortic valve phenotype plays a crucial role in featuring the disturbed flows primarily in ascending aorta, which may relate to the development of aortic diseases.

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Keywords

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