Open Access

ABSTRACT

Mechanical Analysis of a Novel Biodegradable Zinc Alloy Stent Based on Degradation Model

by Kun Peng, Xinyang Cui, Aike Qiao, Makoto Ohta, Koji Shimoyama, Yongliang Mu

1 College of Life Science and Bioengineering, Beijing University of Technology, China.
2 Tohoku University, Japan.
3 Northeastern University, Shenyang, China.
* Corresponding Author: Aike Qiao. Email: qak@bjut.edu.cn.

Molecular & Cellular Biomechanics 2019, 16(Suppl.1), 53-53. https://doi.org/10.32604/mcb.2019.05729

Abstract

Biodegradable stents which can avoid risks caused by incompatibility between artery and permanent stents are attracting much interests. However, biodegradable stents have not been extensively applied in clinical therapy because of their insufficient scaffold performance as a result of poor Young’s Modulus of biodegradable materials and weaken structures in degradation process. In this study, a patented stent and a common stent were simulated to degrade in a 40% stenotic vesel based on a corrosion model involving uniform corrosion and stress corrosion. In the degradation process, the scaffold performance of the two stents and their functionality on reshaping diseased vessels are analyzed. The results showed that radial recoiling ratio and mass loss ratio of the common stent is 22.6% and 14.1%, respectively. In comparison, radial recoiling ratio and mass loss ratio of the common stent are definitely lower than those of the common stent, at the value of 7.19% and 3.1%. It is indicated that the patented stent still has a stronger scaffold performance compared with the common stent. Besides, with positive influence of the patented stent on stenotic vessel, a larger and flatter lumen was observed in the plaque deployed with the patented stent. It implies that mechanical performance of biodegradable stents and their functionality highly depend on their geometries. Owing to improved mechanical performance induced by structural innovation, the novel biodegradable zinc alloy stent is promised to be an alternative choice in intervention surgeries.

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Keywords

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