Open Access

ABSTRACT

The Degree of Question Mark of Aorta Can Predict the Thrombosis Rate in the False Lumen of a Type-B Aortic Dissection After TEVAR

by Da Li, Liqing Peng, Yi Wang, Ding Yuan, Tinghui Zheng

1 Department of Applied Mechanics, Sichuan University, Chengdu, 610065, China.
2 Department of Radiology, West China Hospital, Sichuan University, Chengdu, 610041, China.
3 Department of Computer Science, Sichuan University of Science and Engineering, Zigong, Sichuan, 643000, China.
4 Department vascular surgery of West China Hospital, Sichuan University, Chengdu, 610041, China.
* Corresponding Author: Tinghui Zheng. Email: tinghuizh@scu.edu.cn.
# The authors contributed equally to this work.

Molecular & Cellular Biomechanics 2019, 16(Suppl.1), 39-39. https://doi.org/10.32604/mcb.2019.05718

Abstract

Objective: Thoracic endovascular aortic repair (TEVAR) of type B aortic dissection (AD) is to initiate the thrombosis in the false lumen to eventually result in aortic remodeling. We aim to find out whether the false lumen (FL) thrombosis rate after TEVAR can be predicted accurately by an index that expresses the degree of aortic arch angulation. Method: Three-dimensional aortic arch geometry of 39 type B AD patients (mean age: 48 years) after TEVR were reconstructed from post-operative CT images. For the first time, the question mark which takes into account the curvature of both aortic arch and the descending aorta was introduced to indicate the aortic arch morphology. The degree of question mark and the angles of aortic arch defined by previous literatures were measured. Moreover, hemodynamics for ADs with different question mark degree were numerically computed using different models. Result: No correlation between the aortic arch angles defined by previous researchers and the rate of thrombosis. However, the degree of question mark has negatively correlation with FL thrombosis (r=-.7394; p<.001). In addition, regions of recirculating flow and low wall shear stress (WSS) in the FLs decreased with the increase of the degree of question mark of the aorta. Conclusion: The degree of question mark proposed in this paper is a good description of the aortic arch geometry after TEVAR in patients with aortic B-type dissection. It is negatively correlated with postoperative FL thrombosis, the higher the question mark degree was, the less likely it was to form a complete thrombus.

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