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Megumi Baba¹, Aya Shinmura¹, Shigeru Tada¹, Taku Amo², Akira Tsukamoto^1,*
Molecular & Cellular Biomechanics, Vol.16, No.1, pp. 1-12, 2019, DOI:10.32604/mcb.2019.05199
Abstract Mitochondria in endothelial cells remodel morphologically when supraphysiological cyclic stretch is exerted on the cells. During remodeling, mitochondria become shorter, but how they do so remains elusive. Drp1 is a regulator of mitochondrial morphologies. It shortens mitochondria by shifting the balance from mitochondrial fusion to fission. In this study, we hypothesized that Drp1 activation is involved in mitochondrial remodeling under supraphysiological cyclic stretch. To verify the involvement of Drp1, its activation was first quantified with Western blotting, but Drp1 was not significantly activated in endothelial cells under supraphysiological cyclic stretch. Next, Drp1 activation was inhibited… More >

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Shaoxiong Yang¹, Yingxin Qi², Zonglai Jiang², Xiaobo Gong^1,*
Molecular & Cellular Biomechanics, Vol.16, No.1, pp. 13-26, 2019, DOI:10.32604/mcb.2019.06096
Abstract Vascular diseases during aging process are closely correlated to the age-related changes of mechanical stimuli for resident cells. Characterizing the variations of mechanical environments in vessel walls with advancing age is crucial for a better understanding of vascular remodeling and pathological changes. In this study, the mechanical stress, strain, and wall stiffness of the femoropopliteal arteries (FPAs) were compared among four different age groups from adolescent to young, middle-aged, and aged subjects. The material parameters and geometries adopted in the FPA models were obtained from published experimental results. It is found that high mechanical stress More >

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Xu Zhang^1,‡, Jie Gao^2,‡, Xinke Yao¹, Zhengze Dai^3,4, Gelin Xu^2,*, Yan Cai^1,*, Zhiyong Li^1,5,*
Molecular & Cellular Biomechanics, Vol.16, No.1, pp. 27-39, 2019, DOI:10.32604/mcb.2019.06140
Abstract Digital subtraction angiography (DSA) is often used to evaluate the morphological and pathological changes of cerebral arteries in clinical practice. This study aims to explore the possibility of assessing cerebral hypoperfusion with DSA in patients with carotid stenosis. Thirty patients with a mild to severe stenosis on one side, and a mild stenosis on the other side of the carotid artery were recruited. Frontal, parietal, temporal and occipital lobes were chosen as regions of interest for measuring the quantitative perfusion parameters from their time-density curves (TDCs) of DSA images. The perfusion parameters were compared between… More >

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Zahra Niki Boroujeni¹, Atefeh Shirkav¹, Seyed Ahmad Aleyasin^1,*
Molecular & Cellular Biomechanics, Vol.16, No.1, pp. 41-58, 2019, DOI:10.32604/mcb.2019.04366
Abstract Today, prognosis, diagnosis and treatment of cancers are progressing with non-invasive methods, including investigation and modification of the DNA methylation profile in cancer cells. One of the effective factors in regulating gene expression in mammals is DNA methylation. Methylation alterations of genes by external factors can change the expression of genes and inhibit the cancer. In the present study, we investigated the effect of Down syndrome critical region 1 gene (DSCR1) ectopic expression on the methylation status of the BCL-XL, ITGA6, TCF3, RASSF1A, DOK7, VIM and CXCR4 genes in breast cancer cell lines. The effect of DSCR1 ectopic… More >

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Wenjia Wang^{1, 2}, Xiuqing Qian^{1, 2}, Qi Li^{1, 2}, Gong Zhang^{1, 2}, Huangxuan Zhao^{1, 2}, Tan Li^{1, 2}, Yang Yu^{1, 2}, Hongfang Song^{1, 2, *}, Zhicheng Liu^{1, 2, *}
Molecular & Cellular Biomechanics, Vol.16, No.1, pp. 59-74, 2019, DOI:10.32604/mcb.2019.06393
Abstract Pupillary block is considered as an important cause of primary angle-closure glaucoma (PACG). In order to investigate the effect of pupillary block on the hydrodynamics of aqueous humor (AH) in anterior chamber (AC) and potential risks, a 3D printed eye model was developed to mimic the AH flow driven by fluid generation, the differential pressure between AC and posterior chambers (PC) and pupillary block. Particle image velocimetry technology was applied to visualize flow distribution. The results demonstrated obvious differences in AH flow with and without pupillary block. Under the normal condition (without pupillary block), the… More >

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