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Qingyu Wang¹, Dalin Tang^1,2,*, Gador Canton³, Zheyang Wu², Thomas S. Hatsukami⁴, Kristen L. Billiar⁵, Chun Yuan⁶
Molecular & Cellular Biomechanics, Vol.15, No.4, pp. 189-201, 2018, DOI:10.32604/mcb.2018.04572
Abstract Cardiovascular diseases are closely linked to atherosclerotic plaque development and rupture. Assessment of plaque vulnerability is of fundamental significance to cardiovascular research and disease diagnosis, prevention, treatment and management. Magnetic resonance image (MRI) data of carotid atherosclerotic plaques from 8 patients (5 male, 3 female; age: 62-83, mean=71) were acquired at the University of Washington (UW), Seattle by the Vascular Imaging Laboratory (VIL) with written informed consent obtained. Patient-specific vessel material properties were quantified using Cine MRI data for modeling use. 3D thin-layer models were used to obtain plaque stress and strain for plaque assessment.… More >

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Junhao Yang¹, Chunxiao Chen^1,*, Qingyang Zang¹, Jianfei Li¹
Molecular & Cellular Biomechanics, Vol.15, No.4, pp. 203-214, 2018, DOI:10.32604/mcb.2018.03824
Abstract Pathological slide is increasingly applied in the diagnosis of breast tumors despite the issues of large amount of data, slow viewing and high subjectivity. To overcome these problems, a micrograph recognition method based on convolutional neural network is proposed for pathological slide of breast tumor. Combined with multi-channel threshold and watershed segmentation, a sample database including single cell, adhesive cell and invalid cell was established. Then, the convolution neural network with six layers is constructed, which has ability to classify the stained breast tumor cells with accuracy of more than 90%, and evaluate the proliferation More >

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Zahra Niki Boroujeni¹, Atefeh Shirkav¹, Seyed Ahmad Aleyasin^1,*
Molecular & Cellular Biomechanics, Vol.15, No.4, pp. 215-227, 2018, DOI:10.32604/mcb.2018.01813
Abstract Down syndrome critical region 1 gene (DSCR1) is an anti-angiogenesis gene that inhibits the growth of tumor cells. In this study, the role of autophagy and apoptosis in DSCR1-induced cytotoxicity were investigated in MDA-MB-468 breast cancer cells. Lentivirus vector harboring DSCR1 (LV-DSCR1⁺) was constructed in HEK 293 cells and the optimal dosage of lentivirus vector for infection was determined by the MTT assay. After infection of cells using LV-DSCR1⁺, acridine orange and ethidium bromide staining was performed to investigation of apoptosis and autophagy. Expression of DSCR1 and marker genes for angiogenesis (VEGF), apoptosis (Bax and Bcl2) and autophagy (LC3 More >

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Xiaozhong Chen^1,*, Zhijian Mao¹
Molecular & Cellular Biomechanics, Vol.15, No.4, pp. 229-241, 2018, DOI:10.32604/mcb.2018.03818
Abstract Shape optimization of orthopedic fixation plate is of great importance in the treatment of complex fracture. Therefore, a method in this paper to automatically optimize the complex shape of anatomical plate according to static analysis. Based on the theory of finite element analysis (FEA), our approach is processed as follows. First, the three-dimensional finite element model of the fracture fixation is constructed. Next, according to the type and feature of fracture, the anatomical plate was parameterized in two levels (the bounding surface and plate model). Then, parameter constraints are set up to meet the needs More >

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