TY - EJOU AU - Gao, Lilan AU - Yuan, Qingxian AU - Li, Ruixin AU - Chen, Lei AU - Zhang, Chunqiu AU - Zhang, Xizheng TI - Theoretical Prediction and Experimental Testing of Mechanical Properties for 3D Printed Silk Fibroin-Type II Collagen Scaffolds for Cartilage Regeneration T2 - Molecular \& Cellular Biomechanics PY - 2018 VL - 15 IS - 2 SN - 1556-5300 AB - Silk fibroin-typeⅡcollagen scaffold was made by 3D printing technique and freeze-drying method, and its mechanical properties were studied by experiments and theoretical prediction. The results show that the three-dimensional silk fibroin-typeⅡ collagen scaffold has good porosity and water absorption, which is (89.3%+3.26%) and (824.09%+93.05%), respectively. With the given strain value, the stress of scaffold decreases rapidly firstly and then tends to be stable during the stress relaxation. Both initial and instantaneous stresses increase with increase of applied strain value. The creep strains of scaffold with different stress levels show the two stages: the rapidly increasing stage and the second stable stage. It is noted that the scaffold with compressive stress of less than 35 kPa can recover when the compressive stress is removed. However when the compressive stress is higher than 50 kPa, the scaffold is damaged and its structure is destroyed. Not only the compressive property but tensile property of scaffold are dependent on the applied displacement rate or strain rate. Its compressive elastic modulus and tensile modulus increase with increase of strain rate or displacement rate. The nonlinear relaxation model and creep model were constructed respectively and applied to predict the stress relaxation behavior and creep behavior of scaffold. It is found that there are good agreements between the experimental data and predictions, which mean that the built theoretical model can predict the mechanical behavior of scaffold. KW - Silk fibroin KW - typeⅡcollagen KW - cartilage scaffold KW - low temperature 3D printing technology KW - constitutive model KW - mechanical properties DO - 10.3970/mcb.2018.00329