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Dalin Tang^1,*,2, Heng Zuo^2,*, Chun Yang², Zheyang Wu², Xueying Huang³, Rahul H. Rathod⁴, Alexander Tang⁴, Kristen L. Billiar⁵, Tal Geva⁴
Molecular & Cellular Biomechanics, Vol.14, No.3, pp. 137-151, 2017, DOI:10.3970/mcb.2017.014.137
Abstract Patients with repaired tetralogy of Fallot (TOF) account for the majority of cases with late onset right ventricle failure. Comparing TOF patients with healthy people may provide information to address this challenge. Cardiac magnetic resonance (CMR) data were obtained from 16 TOF patients (patient group, PG) and 6 healthy volunteers (healthy group, HG). At begin-of-ejection, better patient group (n=5, BPG) stress was very close to HG stress (54.7±38.4 kPa vs. 51.2±55.7 kPa, p=0.6889) while worse patient group (n=11, WPG) stress was 84% higher than HG stress (p=0.0418). Stress may be used as an indicator to differentiate BPG patients from WPG… More >

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Ruikai Chen¹, Delphine Dean^1,*
Molecular & Cellular Biomechanics, Vol.14, No.3, pp. 153-169, 2017, DOI:10.3970/mcb.2017.014.153
Abstract Vascular smooth muscle cells (VSMCs) play an important role in regulating blood flow and pressure by contracting and relaxing in response to a variety of mechanical stimuli. A fully differentiated and functional VSMC should have both the ability to contract and relax in response to environmental stimuli. In addition, it should have the proper mechanical properties to sustain the mechanically active vascular environment. Stem cells can differentiate towards VSMC lineages and so could be used as a potential treatment for vascular repair. However, few studies have assessed the time it takes for stems cells to acquire similar mechanical property to… More >

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XiangXie^1,a, Deng Liu^1,a, Daoxi Lei¹, Yongfei Liu¹, Qi Wang¹, Zaien Wen¹, Juhui Qiu¹, Dongyu Jia^1,2, Hans Gregersen¹, Guixue Wang^1,*
Molecular & Cellular Biomechanics, Vol.14, No.3, pp. 171-186, 2017, DOI:10.3970/mcb.2017.014.171
Abstract Research in microgravity is of utmost importance for disclosing the impact of gravity on biological processes and organisms. With the development of space technology, scientists pay more attention to cardiovascular diseases associated with microgravity. However, up to date only sparse data exist on microgravity and cardiovascular development mechanisms. In this study, zebrafish was chosen as the model organism. Zebrafish embryos were exposed to microgravity using a ground-based simulation microgravity (SM) bioreactor. The effects of SM on the development of early embryonic vascular system were studied in vivo in real-time. Zebrafish embryos were selected and divided into two groups at 12… More >

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Baogang Tian¹, Yang Shao¹, Zhijiong Wang¹, Jian Li^2,*
Molecular & Cellular Biomechanics, Vol.14, No.3, pp. 187-194, 2017, DOI:10.3970/mcb.2017.014.187
Abstract The purpose of this study was to explore the clinical efficacy and safety of posterior pedicle screw fixation in the treatment of thoracolumbar burst fracture. A total of 120 patients with thoracolumbar burst fractures were selected from January 2014 to December 2016. 60 patients were divided into the study group, and 60 patients were as the control group. The patients in the study group were treated with posterior pedicle screw fixation. The control group was treated with posterior non-traumatic pedicle screw fixation. After treatment, there were six months follow up. The clinical indexes, complications, and the anterior aspect height ratio,… More >

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