Open Access

ARTICLE

3D Numerical Simulation of Effect of Antiangiogenic Factor Angiostatin on Blood Flow and Interstitial Fluid Pressure in the Metastatic Tumor

Gaiping Zhao¹, Feiyi Xia¹, Eryun Chen², Xiaoli Yu³, Zhaozhi Yang^3,*

1 School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
2 School of Energy and Power Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
3 Fudan University Shanghai Cancer Center, Shanghai 200032, China.

* Corresponding Author: Gaiping Zhao, Email: .

Molecular & Cellular Biomechanics 2017, 14(1), 47-57. https://doi.org/10.3970/mcb.2017.014.049

Abstract

Metastatic tumor blood perfusion and interstitial fluid transport based on 3D microvasculature response to inhibitory effect of angiostatin are investigated in this paper. 3D blood flow、interstitial fluid transport and transvascular flow are described by the extended Poiseuille’s, Darcy’s and Starling’s law, respectively. Numerical solutions reveal that angiostatin can promote improved blood perfusion and decrease elevated interstitial fluid pressure within the metastatic tumor microenvironment. Moreover, angiostatin can increase interstitial convection within the tumor and result in more efficient drug delivery and penetration within the metastatic tumor, which suits well with the experimental observations. Together, our results may provide therapeutic implications for further clinical anti-angiogenic cancer therapy.

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Keywords

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