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Abhishek M. Thote^1,*, Rashmi V. Uddanwadiker¹, Krishna Sharma², Sunita Shrivastava²
Molecular & Cellular Biomechanics, Vol.14, No.1, pp. 1-17, 2017, DOI:10.3970/mcb.2017.014.001
Abstract The objective of this study was to devise an optimum force system to achieve en-masse retraction of six maxillary anterior teeth in lingual orthodontics (LiO). First, the set of equations was developed based on the mathematical computation to estimate optimum parameters of force system. Then, the computer software based on this mathematical computation was developed for the ease of estimation of force system. The verification of force system obtained with computer software was accomplished by three-dimensional finite element analysis (FEA). In FEA, it was clear that the desired en-masse retraction of six maxillary anterior teeth in LiO was achieved as… More >

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Zhen Liu¹, Yan Cai¹, Guo-Zhong Chen², Guang-Ming Lu, Zhi-Yong Li^1,3,*
Molecular & Cellular Biomechanics, Vol.14, No.1, pp. 19-31, 2017, DOI:10.3970/mcb.2017.014.019
Abstract Background: Intracranial aneurysm (IA) can be commonly found in the circle of Willis (CoW), and a higher morbidity of IA is found to be associated with a higher percentage of an incomplete CoW. Hemodynamic factors are believed to play an important role in aneurysm formation. However, how the anatomical variations in CoW lead to hemodynamic difference and what hemodynamic parameters play important roles in aneurysm formation have not been quantified and assessed. Methods and Results: Thirty patients were included and based one computed tomography angiography, they were divided into three groups (10 patients per group): a normal group (normal CoW… More >

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Kun Fan^1,2, Xiaofu Qiu², Yu Fu², Kangjian Lin, Huanhui Li², Guosheng Yang ^*,1,2
Molecular & Cellular Biomechanics, Vol.14, No.1, pp. 33-45, 2017, DOI:10.3970/mcb.2017.014.035
Abstract This study intends to investigate the role of amentoflavone(AF) in human clear-cell renal cell carcinoma (ccRCC) and to elucidate underlying molecular mechanisms. Materials and Methods: Human RCC cell lines Caki-1 and 786-O were used in this study. Cell proliferation, apoptosis, cell cycle distribution and invasion assays were conducted to analyze the effect of AF against ccRCC in vitro. Xenograft model and pulmonary metastasis animal model were established to evaluate the vivo therapeutic efficacy and against pulmonary metastasis ability of AF, respectively. Results: Our findings revealed that AF selectively suppressed tumor cell proliferation in a dose- and time-dependent manner. Treatment with… More >

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Gaiping Zhao¹, Feiyi Xia¹, Eryun Chen², Xiaoli Yu³, Zhaozhi Yang^3,*
Molecular & Cellular Biomechanics, Vol.14, No.1, pp. 47-57, 2017, DOI:10.3970/mcb.2017.014.049
Abstract Metastatic tumor blood perfusion and interstitial fluid transport based on 3D microvasculature response to inhibitory effect of angiostatin are investigated in this paper. 3D blood flow、interstitial fluid transport and transvascular flow are described by the extended Poiseuille’s, Darcy’s and Starling’s law, respectively. Numerical solutions reveal that angiostatin can promote improved blood perfusion and decrease elevated interstitial fluid pressure within the metastatic tumor microenvironment. Moreover, angiostatin can increase interstitial convection within the tumor and result in more efficient drug delivery and penetration within the metastatic tumor, which suits well with the experimental observations. Together, our results may provide therapeutic implications for… More >

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