Open Access
ARTICLE
PoojaJhunjhunwala1, P.M. Padole2, S.B. Thombre3
Molecular & Cellular Biomechanics, Vol.13, No.1, pp. 1-21, 2016, DOI:10.3970/mcb.2016.013.001
Abstract This paper presents Computational fluid dynamic (CFD) analysis of blood flow in three different 3-D models of left coronary artery (LCA). A comparative study of flow parameters (pressure distribution, velocity distribution and wall shear stress) in each of the models is done for a non-Newtonian (Carreau) as well as the Newtonian nature of blood viscosity over a complete cardiac cycle. The difference between these two types of behavior of blood is studied for both transient and steady states of flow. Additionally, flow parameters are compared for steady and transient boundary conditions considering blood as non-Newtonian fluid. The study shows that… More >
Open Access
ARTICLE
Chunliu He1, Jiaqiu Wang2, Yuxiang Huang1, Tongjing Zhu1, Yuehong Miao1, Zhiyong Li1,2*
Molecular & Cellular Biomechanics, Vol.13, No.1, pp. 23-36, 2016, DOI:10.3970/mcb.2016.013.027
Abstract Fibrous cap thickness (FCT) is seen as critical to plaque vulnerability. Therefore, the development of automatic algorithms for the quantification of FCT is for estimating cardiovascular risk of patients. Intravascular optical coherence tomography (IVOCT) is currently the only in vivo imaging modality with which FCT, the critical component of plaque vulnerability, can be assessed accurately. This study was aimed to discussion the correlation between the texture features of OCT images and the FCT in lipid-rich atheroma. Methods: Firstly, a full automatic segmentation algorithm based on unsupervised fuzzy c means (FCM) clustering with geometric constrains was developed to segment the ROIs… More >
Open Access
ARTICLE
Longling Fan1,§, Jing Yao2,§, Chun Yang3, Di Xu2, Dalin Tang1,4*
Molecular & Cellular Biomechanics, Vol.13, No.1, pp. 33-55, 2016, DOI:10.3970/mcb.2016.013.044
Abstract Modeling ventricle active contraction based on in vivo data is extremely challenging because of complex ventricle geometry, dynamic heart motion and active contraction where the reference geometry (zero-stress geometry) changes constantly. A new modeling approach using different diastole and systole zero-load geometries was introduced to handle the changing zero-load geometries for more accurate stress/strain calculations. Echo image data were acquired from 5 patients with infarction (Infarct Group) and 10 without (Non-Infarcted Group). Echo-based computational two-layer left ventricle models using one zero-load geometry (1G) and two zero-load geometries (2G) were constructed. Material parameter values in Mooney-Rivlin models were adjusted to match… More >
Open Access
ARTICLE
Arman Nayebosadri1, Julie Y. Ji2*
Molecular & Cellular Biomechanics, Vol.13, No.1, pp. 57-85, 2016, DOI:10.3970/mcb.2016.013.069
Abstract The glucocorticoid receptor (GR) has multiple phosphorylation sites that can be activated by MAPKs, which have been previously shown to be activated in response to cyclic stretch in endothelial cells. It is possible therefore that physiological and/or pathological degree of cyclic stretch may also initiate phosphorylation-induced changes in GR subcellular localization as we previously showed with shear stress. However, little is known about the effects of cyclic stretch on glucocorticoid receptor (GR) activity in endothelial cells. We used control and lamin shRNA BAECs and subjected them to ligand (dexamethasone) treatment, physiological stretch (10% at 1 Hz), or pathological stretch (20%… More >
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