MCB-Vol. 12, No. 4, 2015

Open Access

ARTICLE

A Coupled Mathematical Model of Cell Migration, Vessel Cooption and Tumour Microenvironment during the Initiation of Micrometastases
Yan Cai^1,2,3, Jie Wu⁴, Zhiyong Li^1,2
Molecular & Cellular Biomechanics, Vol.12, No.4, pp. 231-248, 2015, DOI:10.3970/mcb.2015.012.231
Abstract We propose a coupled mathematical model for the detailed quantitative analyses of initial microtumour and micrometastases formation by including cancer cell migration, host vessel cooption and changes in microenvironment. Migrating cells are included as a new phenotype to describe the migration behaviour of malignant tumour cells. Migration probability of a migrating cell is assumed to be influenced by local chemical microenvironment. Pre-existing vessel cooption and remodelling are introduced according to the local haemodynamical microenvironment, such as interstitial pressure and vessel wall permeability. After the tumour cells and tumour vessels distribution are updated, the chemical substances… More >

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Enhanced External Counterpulsation Treatment May Intervene The Advanced Atherosclerotic Plaque Progression by Inducing The Variations of Mechanical Factors: A 3D FSI Study Based on in vivo Animal Experiment
Jianhang Du^1,2,3, Liang Wang⁴
Molecular & Cellular Biomechanics, Vol.12, No.4, pp. 249-263, 2015, DOI:10.3970/mcb.2015.012.249
Abstract Growing evidences suggest that long-term enhanced external counterpulsation (EECP) treatment can inhibit the initiation of atherosclerotic lesion by improving the hemodynamic environment in aortas. However, whether this kind procedure will intervene the progression of advanced atherosclerotic plaque remains elusive and causes great concern in its clinical application presently. In the current paper, a pilot study combining animal experiment and numerical simulation was conducted to investigate the acute mechanical stress variations during EECP intervention, and then to assess the possible chronic effects. An experimentally induced hypercholesterolemic porcine model was developed and the basic hemodynamic measurement was… More >

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Design of Orthopedic Plates and Its Modification Based on Feature
He Kunjin^1,2, Zou Zeyu¹, Zhang Rongli¹
Molecular & Cellular Biomechanics, Vol.12, No.4, pp. 265-286, 2015, DOI:10.32604/mcb.2015.012.263
Abstract To quickly construct the orthopedic plates and to conveniently edit it, a novel method for designing the plates is put forward based on feature idea and parameterization. Firstly, attached to the existing or repaired bone model, the region of interest (ROI) is selected as the abutted surface of orthopedic plate, and the ROI is reconstructed to form a CAD surface. Secondly, the CAD surface is to be defined as a surface feature (SF) and then some semantic parameters are configured for it. Lastly, the plate body is constructed through thickening, and some higher parameters are More >

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