Open Access

ARTICLE

Trans-scale Granular Modelling of Cytoskeleton: a Mini-Review

by Tong Li∗, Prasad KDV Yarlagadda∗, Adekunle Oloyede∗, NamalThibbotuwawa∗, YuanTong Gu∗, †^†

∗ School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane, Australia.
† Corresponding Author. Telephone: +61-7-31381009; Fax: +61-7-31381469; E-mail: yuantong. gu@qut.edu.au

Molecular & Cellular Biomechanics 2015, 12(1), 17-35. https://doi.org/10.3970/mcb.2015.012.017

Abstract

Living cells are the functional unit of organs that controls reactions to their exterior. However, the mechanics of living cells can be difficult to characterize due to the crypticity of their microscale structures and associated dynamic cellular processes. Fortunately, multiscale modelling provides a powerful simulation tool that can be used to study the mechanical properties of these soft hierarchical, biological systems. This paper reviews recent developments in hierarchical multiscale modeling technique that aimed at understanding cytoskeleton mechanics. Discussions are expanded with respects to cytoskeletal components including: intermediate filaments, microtubules and microfilament networks. The mechanical performance of difference cytoskeleton components are discussed with respect to their structural and material properties. Explicit granular simulation methods are adopted with different coarse-grained strategies for these cytoskeleton components and the simulation details are introduced in this review.

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