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ARTICLE

Chetan Kuthe^∗, R. V. Uddanwadiker^†, P. M. Padole^‡, A. A. Ramteke^§
Molecular & Cellular Biomechanics, Vol.12, No.1, pp. 1-16, 2015, DOI:10.3970/mcb.2015.012.001
Abstract Skeletal muscles are responsible for the relative motion of the bones at the joints and provide the required strength. They exhibit highly nonlinear mechanical behaviour and are described by nonlinear hyperelastic constitutive relations. It is distinct from other biological soft tissue. Its hyperelastic or viscoelastic behaviour is modelled by using CE, SEE, and PEE. Contractile element simulates the behaviour of skeletal muscle when it is subjected to eccentric and concentric contraction. This research aims to estimate the stress induced in skeletal muscle in eccentric and concentric contraction with respect to the predefined strain. With the use of mathematical model for… More >

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Tong Li^∗, Prasad KDV Yarlagadda^∗, Adekunle Oloyede^∗, Namal Thibbotuwawa^∗, YuanTong Gu^∗,†
Molecular & Cellular Biomechanics, Vol.12, No.1, pp. 17-35, 2015, DOI:10.3970/mcb.2015.012.017
Abstract Living cells are the functional unit of organs that controls reactions to their exterior. However, the mechanics of living cells can be difficult to characterize due to the crypticity of their microscale structures and associated dynamic cellular processes. Fortunately, multiscale modelling provides a powerful simulation tool that can be used to study the mechanical properties of these soft hierarchical, biological systems. This paper reviews recent developments in hierarchical multiscale modeling technique that aimed at understanding cytoskeleton mechanics. Discussions are expanded with respects to cytoskeletal components including: intermediate filaments, microtubules and microfilament networks. The mechanical performance of difference cytoskeleton components are… More >

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1019

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P. Jhunjhunwala^∗,†, P.M. Padole^∗,‡, S.B. Thombre^∗,§
Molecular & Cellular Biomechanics, Vol.12, No.1, pp. 37-47, 2015, DOI:10.3970/mcb.2015.012.037
Abstract CFD analysis plays an important role in the area of analysis of blood flow as in-vivo measurements of blood flow is costly and easily not accessible. This paper presents simulation of blood flow in healthy and stenosed coronary artery 2- D models. The simulation was done considering non-Newtonian behavior of blood and pulsatile nature of blood flow which is close to physical scenario. Pressure distribution, velocity distribution and wall shear were examined to understand their effect on Atherosclerosis. More >

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1359

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Xi Zhao^∗, Youjun Liu^∗,†, Wenxin Wang^∗
Molecular & Cellular Biomechanics, Vol.12, No.1, pp. 49-66, 2015, DOI:10.3970/mcb.2015.012.049
Abstract Purpose: Sequential graft and Y-type graft are two different surgical procedures in coronary artery bypass grafting (CABG). The hemodynamic environment of them are different, that may cause different short-term surgical result and long-term patency. In this study, the short-term and long-term result of sequential and Y-type graft was discussed by comparing the hemodynamics of them. Materials and Methods: Two postoperative 3-dimensional (3D) models were built by applying different graft on a patient-specific 3D model with serious stenosis. Then zero-dimensional (0D)/3D coupled simulation was carried out by coupling the postoperative 3D models with a 0D lumped parameter model of the cardiovascular… More >

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