Open Access
ARTICLE
Filamin: A Structural and Functional Biomolecule with Important Roles in Cell Biology, Signaling and Mechanics
Hassan P. Modarres∗, Mohammad R. K. Mofrad†
∗
Molecular Cell Biomechanics Laboratory, Departments of Bioengineering and Mechanical Engineering,
University of California, Berkeley, CA 94720.
†
Corresponding Author. Department of Bioengineering, University of California Berkeley, 208A
Stanley Hall #1762, Berkeley, CA 94720-1762. Phone: (510) 643-8165; Fax: (510) 642-5835;
Email: mofrad@berkeley.edu
Molecular & Cellular Biomechanics 2014, 11(1), 39-65. https://doi.org/10.3970/mcb.2014.011.039
Abstract
Focal adhesions are the immediate sites of the cell’s adhesive interaction with the extracellular matrix and as such play a key role in mechanosensing and mechanotransduction at the edge of the cell interface with its surrounding microenvironment. A multitude of proteins orchestrate this mechanochemical communication process between the cell and its outside world. Filamin is a member of focal adhesion protein machinery that also plays a key role in regulating and bundling the acting filament network. A brief review is presented here on filamin and its important protein partners with the aim to shed light on the role of filamin’s protein-protein interaction network in cell mechanobiology.
Cite This Article
APA Style
Modarres, H.P., Mofrad, M.R.K. (2014). Filamin: A structural and functional biomolecule with important roles in cell biology, signaling and mechanics. Molecular & Cellular Biomechanics, 11(1), 39-65. https://doi.org/10.3970/mcb.2014.011.039
Vancouver Style
Modarres HP, Mofrad MRK. Filamin: A structural and functional biomolecule with important roles in cell biology, signaling and mechanics. Mol Cellular Biomechanics . 2014;11(1):39-65 https://doi.org/10.3970/mcb.2014.011.039
IEEE Style
H.P. Modarres and M.R.K. Mofrad, "Filamin: A Structural and Functional Biomolecule with Important Roles in Cell Biology, Signaling and Mechanics," Mol. Cellular Biomechanics , vol. 11, no. 1, pp. 39-65. 2014. https://doi.org/10.3970/mcb.2014.011.039