Meta-Analysis of the Relationship between Normal Tension Glaucoma, Open-Angle Glaucoma, and Fractional Pressure Reserve
  • Qi Li1,2, Ningli Wang3, Zhicheng Liu1,2, Lin Li1,2, Zhicheng Liu1,2, Wenjia Wang1,2, Xiaoxue Long1,2, Hongfang Song1,2,*
1 School of Biomedical Engineering, Capital Medical University, Beijing, 100069, China
2 Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Capital Medical University, Beijing, 100069, China
3 Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China
* Corresponding Author: Hongfang Song. Email:
Aim: To investigate the relationship between glaucoma and intraocular pressure (IOP), intracranial pressure (ICP), trans-laminar cribrosa pressure difference (TLCPD), and the newly proposed fractional pressure reserve (FPR). Methods: Ten articles were analyzed by meta-analysis, and subgroup analysis of three factors was conducted. Results: The patients with normal tension glaucoma (NTG) and open-angle glaucoma (OAG) have higher TLCPD and lower ICP than healthy subjects, with obvious heterogeneity. The greater heterogeneity may arise from different ICP measurements and from different countries or regions. FPR performs better than TLCPD in some ways. Conclusion: Both FPR and TLCPD can be used as indicators of NTG and OAG, and FPR is more effective than TLCPD in comparisons between different experiments or individuals.
Glaucoma; intraocular pressure; intracranial pressure; trans-laminar cribrosa pressure difference; meta-analysis