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Composite Biomaterials Based on Poly(L-Lactic Acid) and Functionalized Cellulose Nanocrystals

Mariia Stepanova1, Ilia Averianov1, Olga Solomakha1, Natalia Zabolotnykh2, Iosif Gofman1, Mikhail Serdobintsev2, Tatiana Vinogradova2, Viktor Korzhikov-Vlakh1,3, Evgenia Korzhikova-Vlakh1,3,*

1 Institute of Macromolecular Compounds, Russian Academy of Sciences, St. Petersburg, 199004, Russia
2 St. Petersburg Research Institute of Phthisiopulmonology, St. Petersburg, 194064, Russia
3 Institute of Chemistry, Saint-Petersburg State University, St. Petersburg, 199034, Russia

* Corresponding Author: Evgenia Korzhikova-Vlakh. Email:

(This article belongs to this Special Issue: The 10th Conference on Green Chemistry and Nanotechnologies in Polymeric Materials (GCNPM 2019))

Journal of Renewable Materials 2020, 8(4), 383-395.


The biocomposite films were prepared from poly(L-lactic acid) and cellulose nanocrystals. To improve interfacial compatibility of hydrophilic cellulose nanocrystals with hydrophobic matrix polymer as well as to provide the osteoconductive properties, cellulose was functionalized with poly(glutamic acid). The modified cellulose nanocrystals were better distributed and less aggregated within the matrix, which was testified by scanning electron, optical and polarized light microscopy. According to mechanical tests, composites filled with nanocrystals modified with PGlu demonstrated higher values of Young’s modulus, elongation at break and tensile strength. Incubation of composite materials in model buffer solutions for 30 weeks followed with staining of Ca2+ deposits with Alizarin Red S assay testified better mineralization of materials containing PGlu-modified cellulose nanocrystals as filler. As the result of in vivo experiment, the developed composite materials showed less level of inflammation in comparison with pure polymer matrix and composites filled with non-functionalized cellulose nanocrystals.


Cite This Article

Stepanova, M., Averianov, I., Solomakha, O., Zabolotnykh, N., Gofman, I. et al. (2020). Composite Biomaterials Based on Poly(L-Lactic Acid) and Functionalized Cellulose Nanocrystals. Journal of Renewable Materials, 8(4), 383–395.


This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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