Open Access
ARTICLE
Composite Biomaterials Based on Poly(L-Lactic Acid) and Functionalized Cellulose Nanocrystals
Mariia Stepanova1, Ilia Averianov1, Olga Solomakha1, Natalia Zabolotnykh2, Iosif Gofman1, Mikhail Serdobintsev2, Tatiana Vinogradova2, Viktor Korzhikov-Vlakh1,3, Evgenia Korzhikova-Vlakh1,3,*
1 Institute of Macromolecular Compounds, Russian Academy of Sciences, St. Petersburg, 199004, Russia
2 St. Petersburg Research Institute of Phthisiopulmonology, St. Petersburg, 194064, Russia
3 Institute of Chemistry, Saint-Petersburg State University, St. Petersburg, 199034, Russia
* Corresponding Author: Evgenia Korzhikova-Vlakh. Email:
(This article belongs to this Special Issue: The 10th Conference on Green Chemistry and Nanotechnologies in Polymeric Materials (GCNPM 2019))
Journal of Renewable Materials 2020, 8(4), 383-395. https://doi.org/10.32604/jrm.2020.09206
Received 30 November 2019; Accepted 08 January 2020; Issue published 24 April 2020
Abstract
The biocomposite films were prepared from poly(L-lactic acid) and cellulose nanocrystals. To improve interfacial compatibility of hydrophilic cellulose
nanocrystals with hydrophobic matrix polymer as well as to provide the osteoconductive properties, cellulose was functionalized with poly(glutamic acid). The
modified cellulose nanocrystals were better distributed and less aggregated within
the matrix, which was testified by scanning electron, optical and polarized light
microscopy. According to mechanical tests, composites filled with nanocrystals
modified with PGlu demonstrated higher values of Young’s modulus, elongation
at break and tensile strength. Incubation of composite materials in model buffer
solutions for 30 weeks followed with staining of Ca
2+ deposits with Alizarin
Red S assay testified better mineralization of materials containing PGlu-modified
cellulose nanocrystals as filler. As the result of
in vivo experiment, the developed
composite materials showed less level of inflammation in comparison with pure
polymer matrix and composites filled with non-functionalized cellulose
nanocrystals.
Keywords
Cite This Article
Stepanova, M., Averianov, I., Solomakha, O., Zabolotnykh, N., Gofman, I. et al. (2020). Composite Biomaterials Based on Poly(L-Lactic Acid) and Functionalized Cellulose Nanocrystals.
Journal of Renewable Materials, 8(4), 383–395. https://doi.org/10.32604/jrm.2020.09206
Citations