Open Access

ARTICLE

Biorefinery of Rice Husk to Obtain Functionalized Bioactive Compounds

by M. Lopretti, N. Lecot, A. Rodriguez, G. Lluberas, F. Orozco, L. Bolaños, G. Montes De Oca, H. Cerecetto, J. Vega-Baudrit

1 Laboratorio de Técnicas Nucleares Aplicadas a Bioquímica y Biotecnología, Centro de Investigaciones Nucleares-Facultad de Ciencias, Mataojo 2055, Montevideo CP 11400, Uruguay.
2 Área de Radiofarmacia, Centro de Investigaciones Nucleares-Facultad de Ciencias, Mataojo 2055, Montevideo CP 11400, Uruguay.
3 Química Bioanalítica, Instituto Polo Tecnológico de Pando-Facultad de Química, UdelaR, By Pass de Pando y Ruta 8, PandoCanelones CP 91000, Uruguay.
4 Laboratorio de Nacional de Nanotecnología-CeNAT-CONARE, Costa Rica 1174-1200, San José CP 10109, Costa Rica.
5 Laboratorio de Polímeros, POLIUNA-Escuela de Química Universidad Nacional, Heredia, San José CP 86-3000, Costa Rica.
# Equal contribution (First autor): M. Lopretti. Email: mlopretti@gmail.com; N. Lecot. Email: nlecot@cin.edu.uy.

* Corresponding Author:Mary Lopretti. Email: .

Journal of Renewable Materials 2019, 7(4), 313-324. https://doi.org/10.32604/jrm.2019.00008

Abstract

The biomass industrialization valorisation of grains and cereals is considered an opportunity for the countries where agro-industrial activity is one of its main economic activities, rendering new higher-value products with a concomitant solution to waste accumulation issues. To that end, in this work we describe and characterise bioactive compounds generation from rice husk by semi-solid fermentation, obtained from 500 g of the material at room temperature and 60% humidity with mixed cultures of Phanerochaete chrysosporium and Gloeophyllum trabeum. The extract was evaluated in different situations: murine mammary tumour cells (4T1), normal cells (NIH 3T3) and in Lactobacillus acidophilus, and Trichoderma harzianum. The results exhibited that the extract inhibited 4T1 cells at concentrations higher than 20μg/mL, but did not inhibit normal cells, and displayed germicide activity after 3 days incubations. We propose that these functionalized compounds have a potential application in industry/agriculture/medicine obtained from rice husk waste.

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