Open Access

ARTICLE

Biorefinery of Rice Husk to Obtain Functionalized Bioactive Compounds

M. Lopretti^1,*#, N. Lecot^1,2,#, A. Rodriguez³, G. Lluberas¹, F. Orozco⁴, L. Bolaños⁴, G. Montes De Oca⁴, H. Cerecetto², J. Vega-Baudrit^4,5

1 Laboratorio de Técnicas Nucleares Aplicadas a Bioquímica y Biotecnología, Centro de Investigaciones Nucleares-Facultad de Ciencias, Mataojo 2055, Montevideo CP 11400, Uruguay.
2 Área de Radiofarmacia, Centro de Investigaciones Nucleares-Facultad de Ciencias, Mataojo 2055, Montevideo CP 11400, Uruguay.
3 Química Bioanalítica, Instituto Polo Tecnológico de Pando-Facultad de Química, UdelaR, By Pass de Pando y Ruta 8, PandoCanelones CP 91000, Uruguay.
4 Laboratorio de Nacional de Nanotecnología-CeNAT-CONARE, Costa Rica 1174-1200, San José CP 10109, Costa Rica.
5 Laboratorio de Polímeros, POLIUNA-Escuela de Química Universidad Nacional, Heredia, San José CP 86-3000, Costa Rica.
# Equal contribution (First autor): M. Lopretti. Email: mlopretti@gmail.com; N. Lecot. Email: nlecot@cin.edu.uy.

* Corresponding Author:Mary Lopretti. Email: .

Journal of Renewable Materials 2019, 7(4), 313-324. https://doi.org/10.32604/jrm.2019.00008

Abstract

The biomass industrialization valorisation of grains and cereals is considered an opportunity for the countries where agro-industrial activity is one of its main economic activities, rendering new higher-value products with a concomitant solution to waste accumulation issues. To that end, in this work we describe and characterise bioactive compounds generation from rice husk by semi-solid fermentation, obtained from 500 g of the material at room temperature and 60% humidity with mixed cultures of Phanerochaete chrysosporium and Gloeophyllum trabeum. The extract was evaluated in different situations: murine mammary tumour cells (4T1), normal cells (NIH 3T3) and in Lactobacillus acidophilus, and Trichoderma harzianum. The results exhibited that the extract inhibited 4T1 cells at concentrations higher than 20μg/mL, but did not inhibit normal cells, and displayed germicide activity after 3 days incubations. We propose that these functionalized compounds have a potential application in industry/agriculture/medicine obtained from rice husk waste.

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