Vol.7, No.12, 2019, pp.1321-1332, doi:10.32604/jrm.2019.07757
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ARTICLE
Preparation and Properties of Guiqi Polysaccharides/Chitosan/Alginate Composite Hydrogel Microspheres
  • Xiaoliang Zhao1,#, Yuting Wang1,#, Xiuying Pu1, Jianzhong Ma1, Feifan Leng1, Yonggang Wang1, Yanling Wang1, Shuhong Yang1, Fen Ran2, Weijie Zhang1,*
1 School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou, 730050, China.
2 School of Material Science and Engineering, Lanzhou University of Technology, Lanzhou, 730050, China.
# These authors have an equal contribution to the work and should be considered as the co-first author.
* Corresponding Author: Weijie Zhang. Email: .
Abstract
A series of the Guiqi polysaccharides/chitosan/alginate composite hydrogel microspheres (GPcM) with different particle sizes were prepared with Guiqi polysaccharides (GP), chitosan (CS) and sodium alginate (Alg). The optimum preparation process was also determined by single factor and orthogonal experiment analysis. The GPcM were characterized by fourier transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM), drug loading efficiency test (LE), encapsulation efficiency test (EE) and in vitro release study. The results showed that the Guiqi polysaccharides chitosan hydrogel (GPCH) and sodium alginate hydrogel (SAH) formed a crossover system in GPcM. The GPcM have a uniform particle size ranging from 395.1μm to 841.5μm. The drug loading efficiency and encapsulation efficiency of the GPcM were 56.3% and 72.6%, respectively. The bovine serum albumin (BSA) loaded in the GPcM released slowly within 180 h. The results suggested that the GPcM may have potential application value in drug sustained and controlled release system.
Keywords
Guiqi polysaccharides; composite hydrogel microspheres; cross-linker; drug loading
Cite This Article
Zhao, X., Wang, Y., Pu, X., Ma, J., Leng, F. et al. (2019). Preparation and Properties of Guiqi Polysaccharides/Chitosan/Alginate Composite Hydrogel Microspheres. Journal of Renewable Materials, 7(12), 1321–1332.
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