Open Access

ARTICLE

Preparation and Properties of Guiqi Polysaccharides/Chitosan/Alginate Composite Hydrogel Microspheres

Xiaoliang Zhao^1,#, Yuting Wang^1,#, Xiuying Pu¹, Jianzhong Ma¹, Feifan Leng¹, Yonggang Wang¹, Yanling Wang¹, Shuhong Yang¹, Fen Ran², Weijie Zhang^1,*

1 School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou, 730050, China.
2 School of Material Science and Engineering, Lanzhou University of Technology, Lanzhou, 730050, China.
# These authors have an equal contribution to the work and should be considered as the co-first author.

* Corresponding Author: Weijie Zhang. Email: .

Journal of Renewable Materials 2019, 7(12), 1321-1332. https://doi.org/10.32604/jrm.2019.07757

Abstract

A series of the Guiqi polysaccharides/chitosan/alginate composite hydrogel microspheres (GPcM) with different particle sizes were prepared with Guiqi polysaccharides (GP), chitosan (CS) and sodium alginate (Alg). The optimum preparation process was also determined by single factor and orthogonal experiment analysis. The GPcM were characterized by fourier transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM), drug loading efficiency test (LE), encapsulation efficiency test (EE) and in vitro release study. The results showed that the Guiqi polysaccharides chitosan hydrogel (GPCH) and sodium alginate hydrogel (SAH) formed a crossover system in GPcM. The GPcM have a uniform particle size ranging from 395.1μm to 841.5μm. The drug loading efficiency and encapsulation efficiency of the GPcM were 56.3% and 72.6%, respectively. The bovine serum albumin (BSA) loaded in the GPcM released slowly within 180 h. The results suggested that the GPcM may have potential application value in drug sustained and controlled release system.

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Keywords

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