Open Access

ARTICLE

Paracetamol Sensitive Cellulose-Based Electrochemical Sensors

Maxime Pontié^1*, Serge Foukmeniok Mbokou^1,2, Jean-Philippe Bouchara¹, Bienvenue Razafimandimby¹, Sylvie Egloff¹, Ornella Dzilingomo¹, Pierre-Yves Pontalier³, Ignas Kenfack Tonle<

1 Host-Pathogen Interaction Study Group (GEIHP, EA 3142), UNIV Angers, UNIV Brest, Bretagne Loire University, Institute of Health Biology-IRIS, CHU, 4 rue Larrey, 49933 Angers, France
2 Electrochemistry and Chemistry of Materials, Department of Chemistry, University of Dschang, P.O. Box 67 Dschang, Cameroon
3 Toulouse University, INP-ENSIACET, LCA (Laboratory of Agro-industrial Chemistry), 31030 Toulouse France

*Corresponding author:

Journal of Renewable Materials 2018, 6(3), 242-250. https://doi.org/10.7569/JRM.2017.634169

Abstract

Electrochemical determination of paracetamol (PCT) was successfully performed using carbon paste electrodes (CPEs) modified with treated coffee husks (CHt) or cellulose powder (Ce). Scanning electron microscopy was used to characterize unmodified or modified CPEs prior to their use. The electrochemical oxidation of PCT was investigated using square wave voltammetry (SWV) and cyclic voltammetry (CV). The oxidation current density of PCT was two-fold higher with the CPE-CHt sensor and 30% higher with CPE-Ce in comparison with the unmodified CPE, and this correlated with the higher hydrophilicity of the modified electrodes. Using SWV for the electrochemical analysis of PCT, carbon paste electrode modified with raw coffee husks (CPE-CHr) showed the presence of impurities at +0.27 V/SCE, showing the interest in using pure cellulose for the present analytical application. Furthermore, CPE-Ce presented a higher real area compared to CPE-CHr, which explains the increase in the limit of saturation from 400 mg/L to 950 mg/L. The better saturation limit exhibited by CPE-Ce justifies its choice for electroanalysis of PCT in commercialized tablets. The proposed method was successfully applied in the determination of PCT in commercialized tablets (Doliprane® 500) with a recovery rate close to 100%, and no interference with the excipients contained in the tablets analyzed was observed. This novel sensor opens the way for sustainable development of electroanalytical control of drugs sold individually in developing countries.

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Keywords

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