Open Access

ARTICLE

Construction of Customized Bio Incubator and Designing of Tailored Scaffolds for Bone Tissue Engineering from Laboratory Scale Up to Clinical Scale

by Soliman Abdalla^1,2,*, Shiref Kandil²

1 Department of Physics, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
2 Department of Materials Science, Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt

* Corresponding Author: Soliman Abdalla. Email:

(This article belongs to the Special Issue: Advancement of Biopolymers in Biomedical Materials)

Journal of Renewable Materials 2022, 10(11), 2699-2716. https://doi.org/10.32604/jrm.2022.022334

Received 05 March 2022; Accepted 20 April 2022; Issue published 29 June 2022

Abstract

In order to obtain larger, clinical-scale and practical-scale bone grafts, we have designed both tailored scaffolds and tailored bio incubator with optimal bio-production characteristics. Using DIC files to Simpleware Scan-IP (Simple-ware-exeter United Kingdom), we have digitally reconstructed segmental additive bone-tissue in order to perform images processing. Both hydroxyapatite and tannin composites have been used in order to get the final bone modules combined for retexturing of segmental bone defect. We have found that sectioning of bone segment deficiency reorganizations into well disk-shaped design permits one to standardize the cell culture and seeding protocol, to get better products. The present study concludes that some techniques with cultured cell in segmental bone grafts in the laboratory can be transferred and clinically used.

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Keywords

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