Open Access

ARTICLE

Formulation, Optimization and Characterization of Microspheres using Biomaterial Arabinoxylan

JOHAR SHUJAAT¹, ALIA ERUM¹, UME-RUQIA TULAIN¹, SOBIA NOREEN², ASMARA ISMAIL¹

1 College of Pharmacy, University of Sargodha, Sargodha, Pakistan
2 Department of Chemistry, University of Sargodha, Sargodha, Pakistan

* Corresponding Author: e-mail:

Journal of Polymer Materials 2017, 34(4), 809-821.

Abstract

Microspheres of new biomaterial arabinoxylan loaded with levosulpiride a model drug were formulated using ionotropic gelation technique. Microspheres were optimized by using different reaction parameters like cross linkers type and concentrations, concentration of biomaterial arabinoxylan, effect of reaction temperature and reaction time and drug loading method. Nine different formulations were formulated. It was observed that best microspheres were formulated using 10 % CaCl₂ , 3 % arabinoxyaln at 600C temperature and 15 minutes reaction time for curing. Compatibility of arabinoxylan with levosulpiride was tested by using XRD and FTIR techniques. Microsphere formulations were evaluated for percentage yield, flow properties, swelling index, solvent regain and drug release studies. Formulations possessed excellent flow properties as indicated by their angle of repose, Carr’s index, Hausner’s ratio, tapped density and bulk density. SEM showed that microspheres were almost spherical and had rough surface morphology. Levosulpiride release from biomaterial arabinoxylan followed Korsmeyer–Peppas model showing drug release by diffusion and erosion of polymer. So this study provides a scientific evidence for the use of arabinoxylan as an effective alternative to sodium alginate for microsphere formulation.

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