Oncologie

ISSN: 1292-3818 (print) Impact Factor: 0.333
ISSN: 1765-2839 (online) Publication Frequency: Quarterly

About the Journal

Oncologie is aimed to the publication of high quality original research articles, review papers, case report, etc. with an active interest in vivo or vitro study of cancer biology. Study relating to the pathology, diagnosis, and advanced treatment of all types of cancers, as well as research from any of the disciplines related to this field of interest. The journal has English and French bilingual publication.
The French Society of Oncology Surgery (SFCO), associoation francophone des soins oncologiques de support (AFSOS) and the French Federation of Medical Oncologists (FFOM) are affiliated with the journal Oncologie.

Indexing and Abstracting

Science Citation Index Expanded (SciSearch); Journal Citation Reports/Science Edition; SCOPUS; EMBASE; Google Scholar; OCLC; PASCAL; SCImago; Summon by ProQuest

Previously published by Lavoisier (https://www.revuesonline.com/portail/), Oncologie starts to be published by Tech Science Press from 2020. It supports Open Access Policy and an Article Processing Charge (APC) of $1000 US dollars applies to all accepted papers (submitted after 1st February 2021).

Current Issue - Vol.23, No.2, 2021 Most Viewed

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OPEN FORUM
Surgical Oncologists, an Endangered Species?
Chirurgiens Oncologistes, une « Espèce en Voie de Disparition » ?
R. J. Salmon^1,2,*
Oncologie, Vol.23, No.2, pp. 173-176, 2021, DOI:10.32604/Oncologie.2021.017020
Abstract This article has no abstract. More
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REVIEW
MicroRNA in HCC: Biomarkers and Therapeutic Targets
Zheng Wang¹, Yongxia He¹, Yuwei Song¹, Yue Wang², Feng Chen^3,*
Oncologie, Vol.23, No.2, pp. 177-184, 2021, DOI:10.32604/Oncologie.2021.014773
Abstract Hepatocellular carcinoma (HCC) is a malignant tumor with high morbidity and mortality. At present, diagnostic methods such as imaging observation, serum testing and tissue biopsy, as well as treatment methods such as surgical resection, radiotherapy, and chemotherapy have certain limitations in clinical interventions for HCC due to the complex pathogenesis and drug resistance of liver cancer, which seriously affect the survival and prognosis of patients. As a large-scale cytokine, microRNA (miRNA) plays an important role in regulating various life activities of cells. Extensive evidence proved that certain miRNAs are specifically expressed in the tissues and blood of HCC patients, and… More
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ARTICLE
Effect of Cluster Nursing Mode Combined with Blood Pressure Regulation on Surgical Tolerance of Patients with Esophageal Cancer and Hypertension
Hongyan Ai^1,*, Yan Wang², Hongmei Gu²
Oncologie, Vol.23, No.2, pp. 185-193, 2021, DOI:10.32604/Oncologie.2021.016420
Abstract Objective: To explore the effect of the cluster nursing mode combined with blood pressure regulation on the surgical tolerance of patients with esophageal cancer and hypertension. Methods: The clinical data of 86 patients with esophageal cancer and hypertension treated in our hospital (February 2016–February 2017) were retrospectively analyzed. The patients were randomly split into research group and reference group, with 43 cases in each group. The reference group received routine nursing, while the research group received cluster nursing combined with blood pressure regulation. The SBP, DBP and heart rates at D1 (at admission), D2 (2 h before surgery) and D3… More
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ARTICLE
Tolerance and Efficacy of Regorafenib according to UGT Pharmacogenetical Status in the Treatment of Metastatic Refractory Colorectal Cancer
Pierre-Guillaume Poureau^1,2,*, Estelle Dhamelincourt², Jessica Nguyen², Hélène Babey², Emmanuelle Renaud², Margaux Geier², Michèle Boisdron-Celle³, Jean-Philippe Metges²
Oncologie, Vol.23, No.2, pp. 195-202, 2021, DOI:10.32604/Oncologie.2021.015929
Abstract Introduction: Regorafenib is a multi tyrosin-kinase inhibitor prescribed in metastatic refractory colorectal cancer treatment. Its toxicity is significant but inconstant. The metabolism of regorafenib includes oxydation via cytochrome P3A4, then glucuroconjugation. A pharmacogenetical approach of mutational status of Uridine-Diphospho-Glucuronosyltransfersase (UDP-glucuronosyl-transferase, UGT) could be a strategy to optimise the use of regorafenib. Patients and Method: This is a restrospective, unicentric study. All adult patients treated with regorafenib for a metastatic colorectal cancer in our center between 2013 and 2017 were analysed. UGT1A1 polypmorphism was previously researched in the laboratory after written informed consent. Results: Thirty-five patients received regorafenib during the study… More
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ARTICLE
Alteration of Ornithine Metabolic Pathway in Colon Cancer and Multivariate Data Modelling for Cancer Diagnosis
Xin Hu^1,2,#, Fangyu Jing^3,#, Qingjun Wang^1,4, Linyang Shi¹, Yunfeng Cao^4,5, Zhitu Zhu^1,4,*
Oncologie, Vol.23, No.2, pp. 203-217, 2021, DOI:10.32604/Oncologie.2021.016155
Abstract It is noteworthy that colon cancer is the fourth place in new cases and the fifth in mortalities according to global cancer statistics 2018. Tumorigenesis displays specific correlation with metabolic alterations. A variety of metabolites, including ornithine (Orn), are related to colon cancer according to sources of disease metabolic information retrieval in human metabolome database. The metabolic regulation of Orn pathway is a key link in the survival of cancer cells. In this study, the plasma Orn levels in colon cancer patients and healthy participants were measured by liquid chromatography tandem mass spectrometry, and the metabolic disturbances of Orn in… More
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ARTICLE
A Nomogram for Predicting Lateral Lymph Node Metastasis in Cases of Papillary Thyroid Micro-Carcinoma with Suspected Lymph Node Metastasis
Yu Xiao¹, Peng Zhou², Yizi Zheng¹, Chang Zheng¹, Guowen Liu¹, Weixiang Liu^3,*
Oncologie, Vol.23, No.2, pp. 219-228, 2021, DOI:10.32604/Oncologie.2021.016480
Abstract The elevation for lateral lymph node metastasis (LLNM) plays an important role in therapeutic decision-making for thyroid carcinoma. A reliable forecasting model for LLNM in patients with papillary thyroid micro-carcinoma (PTMC) is needed, using clinicopathological characteristics. A total of 576 PTMC patients with suspicious lateral cervical lymph node (II, III, IV or V region) metastasis and known clinicopathological variables were randomly collected at Shenzhen Second People’s Hospital. Cervical lymph node status of every patient was assessed by ultrasonography (US). The patients in this cohort study underwent thyroidectomy and lateral neck lymph node dissection. Univariate analysis and logistic regression analysis were… More
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ARTICLE
Prolonged Survival in Patients with Human Epidermal Growth Factor Receptor-2-Overexpressed Metastatic Breast Cancer after Targeted Therapy is Dominantly Contributed by Luminal-Human Epidermal Growth Factor Receptor-2 Population
Keiichi Kontani^1,*, Kana Kuraishi¹, Shin-ichiro Hashimoto¹, Shoko Norimura², Nozomi Hashimoto¹, Masahiro Ohtani³, Naomi Fujiwara-Honjo⁴, Manabu Date⁵, Koji Teramoto⁶, Hiroyasu Yokomise¹
Oncologie, Vol.23, No.2, pp. 229-239, 2021, DOI:10.32604/Oncologie.2021.016277
Abstract The prognosis of patients with human epidermal growth factor receptor-2 (HER2)-overexpressed metastatic breast cancer (MBC) has improved drastically following the development of anti-HER2 therapies. We question what factors are involved in the improved outcome by the treatment. One hundred and two MBC patients who received chemotherapy were classified into groups according to breast cancer subtype: luminal/HER2-negative (n = 50), HER2 (n = 26), and triple-negative subtypes (n = 26). Clinicopathologic features and clinical outcomes of the groups were compared. Disease-free intervals in the triple-negative group were significantly shorter than those in the other two groups. Age, tumor grade, the number… More
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ARTICLE
Formononetin Inhibits Non-Small Cell Lung Cancer Proliferation via Regulation of mir-27a-3p through p53 Pathway
Chunya Hu, Yu He^*
Oncologie, Vol.23, No.2, pp. 241-250, 2021, DOI: 10.32604/Oncologie.2021.015828
Abstract Objective: The aim of the present study was to investigate the anti-tumor effects of formononetin on human nonsmall cell lung cancer (NSCLC) and its potential molecular mechanism. Methods: A549 cells were treated with different concentrations of formononetin, then detected the cell proliferation, apoptosis and the expression of HIPK2 respectively by MTT assay, flow cytometry analysis and RT-qPCR. Then the interaction between miR- 27a-3p and its target gene HIPK2 was verified through luciferase reporter assay. The expression of miR-27a- 3p, HIPK2, and p53 was detected after being treated with different formononetin concentrations by RT-qPCR and western blot. Results: The results showed… More
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ARTICLE
HBx Downregulates miR-422a Expression via Activation of FOXG1/Q1/E1 in HepG2 Cells
Xiaofan Deng^1,2, Yamei Yang^2,3, Xianfeng Gan^2,3, Gang Wu^2,3,*
Oncologie, Vol.23, No.2, pp. 251-258, 2021, DOI:10.32604/Oncologie.2021.016900
Abstract microRNA-422a (miR-422a) is downregulated in many hematopoietic tumors and solid tumors including hepatocellular carcinoma. We previously demonstrated that hepatitis B virus X protein (HBx) downregulated expression of miR-422a in HCC cell line HepG2 in vitro. However, we explore the mechanisms underlying this action. Forkhead box proteins (FOX) G1/Q1/E1 are known to negatively regulate miR-422a expression, and this prompted us to determine whether HBx suppresses miR-422a expression via activation of FOXG1/Q1/E1. The relationship between FOXG1/Q1/E1 and miR-422a in HepG2 cells stably expressing HBx was assessed with qRT-PCR. The correlation between HBx and FOXG1/Q1/E1 was determined with qRT-PCR and western blot in… More
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ARTICLE
Mir-612 Inhibits Proliferation and Invasion of Urothelial Carcinoma of Bladder Cells through Activating Hippo Pathway via Targeting PMEPA1
Peng Wang, Haiyang Zhang, Zilian Cui, Xunbo Jin^*, Dong Zhang^*
Oncologie, Vol.23, No.2, pp. 259-268, 2021, DOI:10.32604/Oncologie.2021.015503
Abstract Urothelial carcinoma of bladder (UCB) is a common urological malignancy in the world, but its progression mechanism remains unclear. MiR-612 was found as an anti-tumor factor in multiple types of cancer, while few studies have revealed its functions in UCB cells. Based on this, UCB cells such as HTB-9 and HTB-4, and normal urothelial of bladder cells such as SV-Huc1, were used as subjects in this study. Western blot, qRTPCR, CCK-8 assay and transwell assay were used to assess functions of miR-612 in UCB cells. The database, miRWalk, was used to search for potential targets of miR-612, and dual-luciferase reporter… More
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ARTICLE
Awareness of Human Papilloma Virus and Its Association with Cervical Cancer among Female University Students: A Study from United Arab Emirates
Madhumitha Kedhari Sundaram¹, Abdulmajeed G. Almutary², Shafiul Haque³, Faheem SM¹, Arif Hussain^1,*
Oncologie, Vol.23, No.2, pp. 269-277, 2021, DOI:10.32604/Oncologie.2021.016002
Abstract Cervical cancer is the neoplasm of the uterine cervix in women, which is highly preventable. With the advent of vaccination against HPV infection, a gradual decline in the incidence of cervical cancer cases has been observed in developing countries. The developing nations bear the brunt of cervical cancer incidence due to low acceptance of vaccination. This survey-based study was designed to assess the awareness and opinions of female university students regarding human papilloma virus, vaccination and cervical cancer. A survey questionnaire was distributed among female expatriate students (18 to 26 years of age) of a private university. The survey sought… More
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ARTICLE
Growth and Invasion of 3D Spheroid Tumor of HeLa and CasKi Cervical Cancer Cells
Kalaivani Muniandy¹, Zuhaida Asra Ahmad^1,4, Sylvia Annabel Dass¹, Shaharum Shamsuddin², Nethia Mohana Kumaran³, Venugopal Balakrishnan^1,*
Oncologie, Vol.23, No.2, pp. 279-291, 2021, DOI:10.32604/Oncologie.2021.015969
Abstract Spheroids are generally self-assembled cells with the ability to generate their extracellular matrix, including the complex cell-matrix and the cell-cell interactions that resemble the functional characteristics of the corresponding tissue in vivo. The study aimed to develop a three-dimensional (3D) spheroid system for the cervical cancer cell lines, HeLa (HPV18), CaSki (HPV16), SiHa (HPV16), C33A (non-HPV), HT3 (non-HPV) as well as to identify its biological activity in the extracellular form. For the formation of the cervical cancer spheroids, the liquid overlay approach was applied, followed by embedding to the bovine collagen I matrix. Spheroid formation using the liquid overlay approach… More
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ARTICLE
Application Value of Multi-Slice Spiral CT Multiplanar Reconstruction Technique in the Diagnosis and Clinicopathological Analysis of Gastrointestinal Lymphoma
Yongtao Yu, Guangdong Zou^*
Oncologie, Vol.23, No.2, pp. 293-301, 2021, DOI:10.32604/Oncologie.2021.015520
Abstract Objective: The purpose was to explore the value of multi-slice spiral CT (MSCT) multiplanar reconstruction technique in the diagnosis and clinicopathological analysis of gastrointestinal lymphoma (GIL). Methods: 82 GIL patients treated in our hospital from February 2018 to February 2019 were selected as the experimental group of this study, and 82 patients with other gastrointestinal tumors diagnosed by pathology during the same period were selected as the control group. Both groups of patients were scanned by MSCT and analyzed by multiplanar reconstruction technique to compare the diagnostic results and clinicopathological indexes of the two groups. Results: The diagnostic accuracy of… More
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REVIEW
A Narrative Review: Classification of Pap Smear Cell Image for Cervical Cancer Diagnosis
Wan Azani Mustafa^1,*, Afiqah Halim¹, Khairul Shakir Ab Rahman²
Oncologie, Vol.22, No.2, pp. 53-63, 2020, DOI:10.32604/oncologie.2020.013660
Abstract Cervical cancer develops as cells transformation in the cervix of a female that connects the uterus to the vagina. This cancer may impact the columnal epithelial cells of the cervix and therefore can be expanded to the lymphatic and circulatory system (metastasize), sometimes the kidneys, liver, prostate, vagina, and rectum. Many of the cervical cancer patients survived by taking early prevention by undergoing a Pap Smear Test. However, the result of the test usually takes a few weeks which is extremely time-consuming especially at the government hospital. The purpose of this research was to study the detection and classification method… More
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ARTICLE
Analysis of the Effects of Different Surgical Procedures for the Treatment of Thyroid Cancer on the Expression Levels of IL-17, IL-35, and SIL-2R and the Prognostic Factors
Chuanwei Xu¹, Renju Ding², Chuanping Xu^3,*
Oncologie, Vol.22, No.1, pp. 43-51, 2020, DOI:10.32604/oncologie.2020.012445
Abstract To analyze the effects of different surgical procedures for the treatment of thyroid cancer on the expression levels of serum interleukin-17 (IL-17), IL-35, soluble interleukin-2 receptor (SIL-2R), and the prognostic factors. Seventy-eight patients with differentiated thyroid cancer were selected and grouped as control group (CG) (n = 39, underwent subtotal thyroidectomy) and observation group (OG) (n = 39, underwent total thyroidectomy). The serum IL-17, IL-35, and SIL- 2R expression levels; the incidence of complications; and the differentiated thyroid carcinoma (DTC) relapse rate were compared between the two groups. The serum IL-17 and SIL-2R levels were lower in the OG than… More
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ARTICLE
Diagnosis of Lung Cancer Based on Plasma Metabolomics Combined with Serum Markers
Dong Zhang^1,#, Lingxia Tong^2,#, Qingjun Wang¹, Yunfeng Cao³, Yu Gao¹, Donghua Yang¹, Tianhao Bao^4,5, Zhitu Zhu^1,*
Oncologie, Vol.22, No.2, pp. 75-82, 2020, DOI:10.32604/oncologie.2020.012376
Abstract Predicting the onset and metastasis of early tumor is the primary means of improving lung cancer prognosis. The purpose of this study was to identify the ability of plasma metabolomics combined with blood markers to establish benign lung disease versus lung cancer regression models. Blood samples were collected from 174 lung cancer patients, 350 benign lung disease patients and 100 healthy volunteers and the metabolites were analyzed by mass spectrometry. The target metabolites consisted of 23 amino acids, 26 acylcarnitines and 45 conventional blood markers. A regression analysis model was established based on 12 metabolites and five blood markers selected… More
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ARTICLE
Sinomenium Inhibits the Viability of Hepatoma Carcinoma Cells through Activating IFNA2
Jingjing He^1,2, Lingyi Zhang², Dan Guo³, Xingwen Han⁴, Hui Zhang⁵, Liang Wang², Youcheng Zhang^1,*
Oncologie, Vol.22, No.1, pp. 1-12, 2020, DOI:10.32604/oncologie.2020.012436
Abstract Hepatocellular carcinoma (HCC) ranks the sixth place of most common cancers. Meanwhile, it is the tertiary mortality cause of cancer. There is no effective therapeutic method to prevent and treat the liver cancer. Sinomenine is a kind of Chinese traditional medicine herbal, it is reported that it can inhibit the viability of several cancer cells. The study is to explore whether sinomenine is also able to inhibit the cell viability of HCC and its potential mechanism. The IC50 of sinomenine in BEL-7402 cells was 5.351 mmol/L, and the IC50 of sinomenine in SMMC-7721 cells was 6.204 mmol/L. The gene expression… More
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ARTICLE
Diagnostic Performance of Serum miR-586 and miR-493 in Patients with Osteosarcoma
Hao Dang^*
Oncologie, Vol.22, No.1, pp. 35-42, 2020, DOI:10.32604/oncologie.2020.012485
Abstract This study aimed to explore the expression and diagnostic performance of miR-586 and miR-493 in patients with osteosarcoma. We enrolled 63 patients with osteosarcoma treated between May 2016 and May 2019 as the experimental group and 55 healthy volunteers who underwent physical examination during the same period as the control group. We detected miR-586 and miR-493 expression in serum, normal bone tissue, and tumor samples. We also evaluated the relationship between clinical indicators and the miR-586 and miR-493 expression levels. The correlation between the serum and osteosarcoma tissue expression of miR-586 and miR-493 was examined by Pearson analysis. Furthermore, the… More
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ARTICLE
Expression Changes, Prognostic Analysis and Risk Factors of miR-625-3p and miR-449a in Osteosarcoma Patients after Surgery
Hui Zhang, Zhan Wang, Lin Liu, Fuqiang Zhang, Yuxin Song, Yaowen Qian^*
Oncologie, Vol.22, No.1, pp. 23-33, 2020, DOI:10.32604/oncologie.2020.012493
Abstract The expression changes of miR-625-3p and miR-449a in osteosarcoma patients after surgery is the critical study in this paper. Analysis of their prognosis and risk factors can be helpful in understanding the prognostic value for clinical purposes. Fifty-eight patients with osteosarcoma diagnosed in our hospital were considered as the research group (RG), and 52 health subjects at the same time were collected as the control group (CG). Fluorescence quantitative PCR (RTPCR) was employed to test the expression levels of miR-625-3p and miR-449a in the serum of subjects in both groups before surgery and patients in the RG after surgery. The… More
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