Oncologie

ISSN: 1292-3818 (print) Impact Factor: 0.9
ISSN: 1765-2839 (online) Publication Frequency: Quarterly

About the Journal

Oncologie is aimed to the publication of high quality original research articles, review papers, case report, etc. with an active interest in vivo or vitro study of cancer biology. Study relating to the pathology, diagnosis, and advanced treatment of all types of cancers, as well as research from any of the disciplines related to this field of interest. The journal has English and French bilingual publication.
The French Society of Oncology Surgery (SFCO), associoation francophone des soins oncologiques de support (AFSOS) and the French Federation of Medical Oncologists (FFOM) are affiliated with the journal Oncologie.

Indexing and Abstracting

Science Citation Index Expanded (SciSearch): 2021 Impact Factor 0.9; Journal Citation Report/Science Edition (JCR); Scopus; Scopus Citescore (Impact per Publication 2021): 0.5; EMBASE; Google Scholar; OCLC; PASCAL; SCImago; Summon by ProQuest

Current Issue - Vol.24, No.2, 2022 Most Viewed

OPEN ACCESS
ARTICLE IN FRENCH
Breast Cancer in Bobo-Dioulasso, Burkina Faso: Management Outcomes
Le Cancer du Sein à Bobo-Dioulasso, Burkina Faso : Résultats de la Prise en Charge
Ollo Roland Somé^1,*, Abdoul Halim Bagué², Damien Konkobo¹, Dieudonné Hien³, Adama Dembélé³, GL Hermann Bélemlilga¹, Valentin Konségré⁴, Nayi Zongo⁵
Oncologie, Vol.24, No.2, pp. 173-184, 2022, DOI:10.32604/oncologie.2022.021250
Abstract Introduction: Breast cancer management in Sub-Saharian Africa, is faced with diagnosis and treatment challenges. This study aims to describe, breast cancers epidemiology in Bobo-Dioulasso, Burkina Faso. Patients and method: A retrospective cohort study was performed from July 01, 2015 to December 31, 2021 in the Souro Sanou university teaching hospital. Histologically confirmed breast cancer patients were included. Clinical aspect, treatment features and outcome data were collected and analyzed. Results: In study time, eight male’s cases (2%) 360 female’s cases among 368 breast cancers cases were included. The mean age was 46.6 ± 12.1 years, ranging from 15 to 90. The… More
Views:522 Downloads:177 Download PDF

OPEN ACCESS
REVIEW
Delaying Emergence of Resistance to KRAS Inhibitors with Adaptive Therapy: “Treatment-to-Contain” Instead of “Treatment-to-Cure”
Amir Imran Faisal Hamdi, Johnson Stanslas^*
Oncologie, Vol.24, No.2, pp. 185-194, 2022, DOI:10.32604/oncologie.2022.023629
Abstract KRAS mutations are among the most common oncogenic abnormalities in cancer. Until recently, drug discovery pursuing KRAS did not produce therapeutic benefits for patients. Specific KRAS inhibitors, such as sotorasib and adagrasib, which bind covalently to codon 12 of substituted glycine to cysteine residue of the protein (G12C), have been approved by the FDA recently for the treatment of lung cancers. Binding of these drugs to the protein inhibits the activation of the GDP-bound inactive state to the GTP-bound active state. Phase 1/2 trials have shown potential anti-tumor activity, particularly in patients with previously treated non-small cell lung cancer. Acquired… More
Views:379 Downloads:226 Download PDF

OPEN ACCESS
REVIEW
Use of the Naphthoquinone YM155 (Sepantronium Bromide) in the Treatment of Cancer: A Systematic Review and Meta-Synthesis
Dariimaa Ganbat^1,2, Bat-Erdene Jugder³, Lkhamaa Ganbat⁴, Miki Tomoeda⁵, Erdenetsogt Dungubat^2,6, Ambaga Miyegombo⁷, Gantsetseg Garmaa⁸, Yoshihisa Takahashi⁶, Ryuji Fukuzawa⁶, Ichiro Mori⁶, Takayuki Shiomi⁶, Akinori Nakata⁹, Yasuhiko Tomita^6,*
Oncologie, Vol.24, No.2, pp. 195-225, 2022, DOI:10.32604/oncologie.2022.022299
Abstract Most cancer cells overexpress the anti-apoptotic protein survivin and display redox dysregulation originating from genotypic and phenotypic alterations. These disturbances contribute to the uncontrolled proliferation, invasion, and chemoresistance of cancer cells, yet they also represent a specific vulnerability that could be exploited therapeutically in selected tumors. YM155 (sepantronium bromide) is a naphthoquinone-containing imidazolebased compound that selectively inhibits survivin expression at the transcriptional and post-transcriptional levels. Here, we performed a systematic review and meta-analysis of clinical studies in which YM155 was administered as monotherapy or combination therapy for patients with cancer. We assessed fully or partially reported clinical outcomes and pharmacological… More
Views:426 Downloads:190 Download PDF

OPEN ACCESS
REVIEW
The Effect of Oncogene Proteins of Human Papillomaviruses on Apoptosis Pathways in Prostate Cancer
Robabeh Faghani Baladehi^1,2, Mohammad Yousef Memar¹, Abolfazl Jafari Sales³, Ahad Bazmani^1,4, Javid Sadri Nahand^1,5,6, Parisa Shiri Aghbash^2,7, Hossein Bannazadeh Baghi^1,2,7,*
Oncologie, Vol.24, No.2, pp. 227-245, 2022, DOI:10.32604/oncologie.2022.020648
Abstract The ability of host cells to activate apoptosis is perhaps the most potent weapon for helping cells eliminate viruses. Human papillomaviruses (HPV) activate several pathways, enabling the infected cells to avoid extrinsic and intrinsic apoptosis pathways. The incapacity of prostatic epithelial cells to induce apoptosis leads to the invasive development of prostate cancer. For the pathogenesis of prostate cancer, several risk factors have been reported; for example, some viruses and infectious diseases have been proposed as causative agents for their relation to prostate diseases. According to several studies, high-risk human papillomaviruses cause malignancy by interfering with the apoptotic and inflammatory… More
Views:563 Downloads:216 Download PDF

OPEN ACCESS
REVIEW
Progression of Exosome-Mediated Chemotherapy Resistance in Cancer
Haojie Zhang¹, Xiaohong Wang^2,*, Yue Yu², Zhenlin Yang^3,*
Oncologie, Vol.24, No.2, pp. 247-259, 2022, DOI:10.32604/oncologie.2022.020993
Abstract Chemotherapy plays an important role in controlling cancer progression, but the long-term use of chemotherapeutic agents can lead to drug resistance and eventually treatment failure. Therefore, elucidation of the mechanism of drug resistance is the key to solve the problem of chemotherapy resistance. In recent years, exosomes derived from tumor cells have received extensive attention from researchers. In this paper, we reviewed the role and mechanism of exosome-mediated tumor drug resistance in recent years, summarized the related studies of exosome and chemotherapy drug resistance, and focused on several different ways by which exosomes participate in tumor drug resistance. It includes… More
Views:323 Downloads:114 Download PDF

OPEN ACCESS
ARTICLE
The Transcriptional and Immunological Roles of Six2 in Clear Cell Renal Cell Carcinoma
Dayu Tian¹, Yang Shi¹, Li Lei¹, Xiangmin Qiu¹, Tao Song^2,*, Qianyin Li^1,*
Oncologie, Vol.24, No.2, pp. 261-282, 2022, DOI:10.32604/oncologie.2022.022838
（This article belongs to this Special Issue: Cancer Immunotherapy)
Abstract Background: Six2, a transcription factor, exerts an oncogenic role in clear cell renal cell carcinoma (ccRCC). Increased Six2 expression could enhance cancer metastasis. However, the regulatory mechanism of Six2 in promoting metastasis remains unclear. The purpose of this study is to analyze the regulatory pattern of Six2 and the potential role of Six2 in the tumor immune microenvironment. Materials and Methods: Firstly, transcriptional data in TCGA-KIRC cohorts was used to analyze the relationship between Six2 expression and clinical information. Secondly, we detect the association between Six2 and the tumor immune microenvironment in ccRCC. Then, we analyzed Six2-related differentially expressed genes… More
Views:288 Downloads:211 Download PDF

OPEN ACCESS
ARTICLE
Paclitaxel Combined with Ticagrelor Inhibits B16F10 and Lewis Lung Carcinoma Cell Metastasis
Xingjun Meng^1,#, Zhihui Cao^2,#, Renfeng Liu^3,#, Kai Zheng⁴, Shuai Ding⁵, Yuefan Gu⁴, Yonghua Chen⁶, Jun Lv⁷, Ping Li⁸, Li Zhou⁹, Wenbo Wang¹⁰, Shiliang Ji¹¹, Hui He^12,*, Hui Yang^9,*
Oncologie, Vol.24, No.2, pp. 283-294, 2022, DOI:10.32604/oncologie.2022.021259
Abstract It is widely accepted that tumor metastasis is the dominant factor leading to cancer-related death. Tumor metastasis is mediated by cell invasion, blood circulation and lymphatic circulation. Paclitaxel, as a common anti-tumor drug and a mitotic inhibitor, promotes microtubule assembly and inhibits microtubule depolymerization. In addition, ticagrelor, an anti-platelet drug, is used to treat acute coronary syndrome. Increasing numbers of studies have reported that platelets can facilitate tumor metastasis. Therefore, inhibiting the effects of platelets can serve as a novel therapeutic strategy for cancer. To explore the effect of anti-tumor and anti-platelet drugs on tumor progression, we chose paclitaxel and… More
Views:295 Downloads:106 Download PDF

OPEN ACCESS
ARTICLE
Chinese Herbal Prescription QYSL Prevents Progression of Lung Cancer by Targeting Tumor Microenvironment
Yang Chen^1,#, Huan Wu^2,#, Annan Jiao³, Jiabing Tong⁴, Jie Zhu⁵, Mei Zhang¹, Zegeng Li^4,*, Ping Li^1,*
Oncologie, Vol.24, No.2, pp. 295-307, 2022, DOI:10.32604/oncologie.2022.022116
Abstract Objectives: Lung cancer is a common and malignant tumor in adults and ranks first in the incidence and mortality of the top five malignant tumors in China. Our previous studies have shown that QYSL prescription can balance lung cancer mice Th1/Th2 and inhibit tumor cell immune escape. Here, we examined the effects of QYSL on lung cancer associated macrophage and the potential associated mechanism. Methods: C57BL/6 mice were injected with Lewis lung cancer cells and treated with QYSL. FACS, RT-PCR, and western blot were used to examined the effect of QYSL on tumor immune microenvironment. Results: We found QYSL inhibited… More
Views:385 Downloads:171 Download PDF

OPEN ACCESS
ARTICLE
An ISSA-RF Algorithm for Prediction Model of Drug Compound Molecules Antagonizing ERα Gene Activity
Minxi Rong¹, Yong Li^1,*, Xiaoli Guo^1,*, Tao Zong², Zhiyuan Ma², Penglei Li²
Oncologie, Vol.24, No.2, pp. 309-327, 2022, DOI:10.32604/oncologie.2022.021256
Abstract Objectives: The ERα biological activity prediction model is constructed by the compound molecular data of the anti-breast cancer therapeutic target ERα and its biological activity data, which improves the screening efficiency of anti-breast cancer drug candidates and saves the time and cost of drug development. Methods: In this paper, Ridge model is used to screen out molecular descriptors with a high degree of influence on the biological activity of Erα and divide datasets with different numbers of the molecular descriptors by screening results. Random Forest (RF) is trained by Root Mean Square Error (RMSE) and Coefficient of determination (R²) to… More
Views:365 Downloads:114 Download PDF

OPEN ACCESS
ARTICLE
Development and Validation of a Nomogram Model to Predict the Prognosis of Intrahepatic Cholangiocarcinoma
Yi Chen^1,#, Liyun Huang^1,#, Zuwu Wei¹, Xiaoling Liu¹, Lihong Chen^1,2,*, Bin Wang^1,2,*
Oncologie, Vol.24, No.2, pp. 329-340, 2022, DOI:10.32604/oncologie.2022.022521
Abstract Background: The effective method for predicting prognosis of ICC is still lack. This study aims to establish and verify an effective prognostic nomogram model for intrahepatic cholangiocarcinoma (ICC) after partial hepatectomy. Materials and Methods: A nomogram model was developed in a cohort of 127 patients from January 2015 to December 2019. General clinical characteristics including preoperative physical examination data and postoperative pathological features were obtained. The independent risk factors identified by univariate and multivariate COX proportional hazards regression models were used to construct nomogram model. Predictive accuracy and discriminative ability were determined using a concordance index and a calibration curve.… More
Views:363 Downloads:186 Download PDF

OPEN ACCESS
CASE REPORT
Delayed Bilateral, Post-Traumatic Extra-Subdural Hematomas in a Patient with Meningioma
Giuseppe Emmanuele Umana^1,*, Gianluca Ferini², Antonio Crea¹, Bipin Chaurasia³, Vishal Chavda⁴, Leonardo Corbino¹, Daniele Franceschini¹, Maria Grazia Tranchina⁵, Marco Fricia¹, Francesca Graziano⁶, Giovanni Federico Nicoletti⁶, Salvatore Cicero¹, Gianluca Scalia⁶
Oncologie, Vol.24, No.2, pp. 341-348, 2022, DOI:10.32604/oncologie.2022.021347
Abstract Concomitant acute epidural hematoma (EDH) and subdural hematoma (SDH) is a rare finding, and its bilateral onset has not yet been reported in literature. We present the first report of a patient affected by post-traumatic concomitant EDH and SDH, with the contralateral, delayed onset of another, associated with meningioma previously treated with gamma knife. A 60-year-old female patient with a history of simple focal seizures with motor symptoms and well-controlled by drugs since childhood, arterial hypertension, and incidental diagnosis of multiple meningiomas was referred to our department after falling down the stairs. Initially, the patient was prescribed gamma knife treatment… More
Views:531 Downloads:163 Download PDF

OPEN ACCESS
CASE REPORT
Surgery Combined with Molecular Targeted Therapy Successfully Treated Giant Esophageal Gastrointestinal Stromal Tumor
Mengjie Li^1,#, Jun Wei^2,#, Guihua Xu^3,#, Ying Liu^3,*, Jian Zhu^3,*
Oncologie, Vol.24, No.2, pp. 349-356, 2022, DOI:10.32604/oncologie.2022.022436
Abstract Gastrointestinal stromal tumors (GISTs) are rare neoplasms arising from mesenchymal cells of the digestive tract and abdomen. Only a few isolated cases of giant esophageal GISTs (greater than 5 cm in size) have been reported with clinical features and surgical methods. Radical esophagectomy with negative margins, followed by gastric tube reconstruction, is recommended for giant esophageal GISTs. However, patients undergoing this type of surgery experienced a sharp decrease in food intake (due to the removal of most of the stomach) and were prone to eating regurgitation, resulting in poor quality of life. We describe the case of a 65-year-old man… More
Views:350 Downloads:184 Download PDF

OPEN ACCESS
REVIEW
A Narrative Review: Classification of Pap Smear Cell Image for Cervical Cancer Diagnosis
Wan Azani Mustafa^1,*, Afiqah Halim¹, Khairul Shakir Ab Rahman²
Oncologie, Vol.22, No.2, pp. 53-63, 2020, DOI:10.32604/oncologie.2020.013660
Abstract Cervical cancer develops as cells transformation in the cervix of a female that connects the uterus to the vagina. This cancer may impact the columnal epithelial cells of the cervix and therefore can be expanded to the lymphatic and circulatory system (metastasize), sometimes the kidneys, liver, prostate, vagina, and rectum. Many of the cervical cancer patients survived by taking early prevention by undergoing a Pap Smear Test. However, the result of the test usually takes a few weeks which is extremely time-consuming especially at the government hospital. The purpose of this research was to study the detection and classification method… More
Views:3069 Downloads:2135 Cited by:3 Download PDF

OPEN ACCESS
ARTICLE
Analysis of the Effects of Different Surgical Procedures for the Treatment of Thyroid Cancer on the Expression Levels of IL-17, IL-35, and SIL-2R and the Prognostic Factors
Chuanwei Xu¹, Renju Ding², Chuanping Xu^3,*
Oncologie, Vol.22, No.1, pp. 43-51, 2020, DOI:10.32604/oncologie.2020.012445
Abstract To analyze the effects of different surgical procedures for the treatment of thyroid cancer on the expression levels of serum interleukin-17 (IL-17), IL-35, soluble interleukin-2 receptor (SIL-2R), and the prognostic factors. Seventy-eight patients with differentiated thyroid cancer were selected and grouped as control group (CG) (n = 39, underwent subtotal thyroidectomy) and observation group (OG) (n = 39, underwent total thyroidectomy). The serum IL-17, IL-35, and SIL- 2R expression levels; the incidence of complications; and the differentiated thyroid carcinoma (DTC) relapse rate were compared between the two groups. The serum IL-17 and SIL-2R levels were lower in the OG than… More
Views:2609 Downloads:1973 Cited by:7 Download PDF

OPEN ACCESS
ARTICLE
Diagnosis of Lung Cancer Based on Plasma Metabolomics Combined with Serum Markers
Dong Zhang^1,#, Lingxia Tong^2,#, Qingjun Wang¹, Yunfeng Cao³, Yu Gao¹, Donghua Yang¹, Tianhao Bao^4,5, Zhitu Zhu^1,*
Oncologie, Vol.22, No.2, pp. 75-82, 2020, DOI:10.32604/oncologie.2020.012376
Abstract Predicting the onset and metastasis of early tumor is the primary means of improving lung cancer prognosis. The purpose of this study was to identify the ability of plasma metabolomics combined with blood markers to establish benign lung disease versus lung cancer regression models. Blood samples were collected from 174 lung cancer patients, 350 benign lung disease patients and 100 healthy volunteers and the metabolites were analyzed by mass spectrometry. The target metabolites consisted of 23 amino acids, 26 acylcarnitines and 45 conventional blood markers. A regression analysis model was established based on 12 metabolites and five blood markers selected… More
Views:2382 Downloads:1492 Download PDF

OPEN ACCESS
ARTICLE
Expression Changes, Prognostic Analysis and Risk Factors of miR-625-3p and miR-449a in Osteosarcoma Patients after Surgery
Hui Zhang, Zhan Wang, Lin Liu, Fuqiang Zhang, Yuxin Song, Yaowen Qian^*
Oncologie, Vol.22, No.1, pp. 23-33, 2020, DOI:10.32604/oncologie.2020.012493
Abstract The expression changes of miR-625-3p and miR-449a in osteosarcoma patients after surgery is the critical study in this paper. Analysis of their prognosis and risk factors can be helpful in understanding the prognostic value for clinical purposes. Fifty-eight patients with osteosarcoma diagnosed in our hospital were considered as the research group (RG), and 52 health subjects at the same time were collected as the control group (CG). Fluorescence quantitative PCR (RTPCR) was employed to test the expression levels of miR-625-3p and miR-449a in the serum of subjects in both groups before surgery and patients in the RG after surgery. The… More
Views:2279 Downloads:1830 Download PDF

OPEN ACCESS
ARTICLE
Sinomenium Inhibits the Viability of Hepatoma Carcinoma Cells through Activating IFNA2
Jingjing He^1,2, Lingyi Zhang², Dan Guo³, Xingwen Han⁴, Hui Zhang⁵, Liang Wang², Youcheng Zhang^1,*
Oncologie, Vol.22, No.1, pp. 1-12, 2020, DOI:10.32604/oncologie.2020.012436
Abstract Hepatocellular carcinoma (HCC) ranks the sixth place of most common cancers. Meanwhile, it is the tertiary mortality cause of cancer. There is no effective therapeutic method to prevent and treat the liver cancer. Sinomenine is a kind of Chinese traditional medicine herbal, it is reported that it can inhibit the viability of several cancer cells. The study is to explore whether sinomenine is also able to inhibit the cell viability of HCC and its potential mechanism. The IC50 of sinomenine in BEL-7402 cells was 5.351 mmol/L, and the IC50 of sinomenine in SMMC-7721 cells was 6.204 mmol/L. The gene expression… More
Views:2244 Downloads:1881 Download PDF

OPEN ACCESS
ARTICLE
Diagnostic Performance of Serum miR-586 and miR-493 in Patients with Osteosarcoma
Hao Dang^*
Oncologie, Vol.22, No.1, pp. 35-42, 2020, DOI:10.32604/oncologie.2020.012485
Abstract This study aimed to explore the expression and diagnostic performance of miR-586 and miR-493 in patients with osteosarcoma. We enrolled 63 patients with osteosarcoma treated between May 2016 and May 2019 as the experimental group and 55 healthy volunteers who underwent physical examination during the same period as the control group. We detected miR-586 and miR-493 expression in serum, normal bone tissue, and tumor samples. We also evaluated the relationship between clinical indicators and the miR-586 and miR-493 expression levels. The correlation between the serum and osteosarcoma tissue expression of miR-586 and miR-493 was examined by Pearson analysis. Furthermore, the… More
Views:2239 Downloads:1733 Download PDF