Congenital Heart Disease

About the Journal

Congenital Heart Disease is an Open Access Peer-review journal focused exclusively on the study and treatment of congenital defects in children and adults. We are dedicated to publishing the Research Articles, Reviews, Viewpoints, Editorials, Meeting Abstracts, and Case Reports (primarily by invitation). Congenital Heart Disease aims to provide superior author services. All manuscripts (including invited) will go through a stringent and thorough editorial procedure, including initial checks and peer-review, to promote reliable research findings.

Indexing and Abstracting

Science Citation Index Expanded (Clarivate Analytics): 2020 Impact Factor: 2.007; Scopus CiteScore (Impact per Publication 2020): 3.4; SNIP (Source Normalized Impact per Paper 2020): 1.01; Journal Citation Report/Science Edition (JCR); etc.

  • New Insights into Sinus Venosus Defects from Cross-Sectional Imaging
  • Abstract Sinus venosus defects include two varieties, superior and inferior sinus venosus defects. The superior sinus venosus defect is characterized by abnormal communication between two closely related venoatrial structures: 1) the normally positioned superior vena cava-right atrium complex and 2) the right pulmonary vein-left atrium complex that is displaced leftward, forward and upward. Inferior sinus venosus defects primarily involve the inferior vena cava-right atrial junction while the right pulmonary vein-left atrial junction can also be affected. Because of the rarity and wide variation of the defects, the morphological characterization of sinus venosus defects is inconsistent among investigators and often inaccurate. Modern… More
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  • Characteristics of In-Hospital Patients with Congenital Heart Disease Requiring Rapid Response System Activations: A Japanese Database Study
  • Abstract Objectives: This study aimed to study the characteristics of in-hospital deterioration in patients with congenital heart disease who required rapid response system activation and identify risk factors associated with 1-month mortality. Methods: We retrospectively analysed data from a Japanese rapid response system registry with 35 participating hospitals. We included consecutive patients with congenital heart disease who required rapid response system activation between January 2014 and March 2018. Logistic regression analyses were performed to examine the associations between 1-month mortality and other patient-specific variables. Results: Among 9,607 patients for whom the rapid response system was activated, only 82 (0.9%) had congenital… More
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  • Ductus Arteriosus Stent Compared with Surgical Shunt for Infants with Ductal-Dependent Pulmonary Blood Flow: A Systematic Review and Meta-Analysis
  • Abstract The aim of this study was to perform a systematic review and meta-analysis to evaluate the safety and efficacy of ductus arteriosus stent (DAS) compared with surgical systemic-pulmonary artery shunt (SPS) in patients with ductal-dependent pulmonary blood flow. A literature search was conducted in PubMed, Embase, and the Cochrane Library databases from their inception to December 2020. Two reviewers independently screened the articles, evaluated the quality of the articles, and collected the data. Meta-analyses were conducted using fixed and random effects models. We used the I-square (I2 ) test to examine heterogeneity and the funnel plot Egger’s test was used… More
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  • Simultaneous Transcatheter Closure of the Left Atrial Appendage and Congenital Interatrial Communication Closure
  • Abstract Background: Left atrial appendage closure (LAAC) with simultaneous interventional occlusion therapy for congenital interatrial communication has become a new focus of patients with nonvalvular atrial fibrillation. Little is known about the results of mid-and long-term results. Objective: The aim of this study was to evaluate the midand long-term safety and effectiveness of simultaneous transcatheter closure of the left atrial appendage (LAA) and congenital interatrial communication closure in atrial fibrillation (AF) patients. Methods: From Jan 2016 to June 2017, 27 patients with AF were treated with simultaneous transcatheter closure of the LAA and atrial septal defect (ASD, n = 22), patent… More
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  • The Glenn Shunt Revisited, A Single Center Registry in Ain Shams University Cardiology Department
  • Abstract Background: Bidirectional Glenn shunts have long been available as palliative procedures for patients with single ventricle physiology that is, patients unsuitable for biventricular repair. In our country they are performed at an older age than that recommended by the literature. So, we aim to assess post bidirectional Glenn shunt patients to detect the presence of any complications and to evaluate their functional capacity. Methods: This was a descriptive study that included all patients who underwent a bidirectional Glenn shunt and were referred for follow up in Ain shams university hospitals. History taking including NYHA class and physical activity, clinical examination,… More
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  • Assessment of Reversibility in Pulmonary Hypertension Related to Congenital Heart Disease by Using Biomarkers and Clinical Features
  • Abstract Background: Reversibility of pulmonary hypertension (PH) is closely related to the treatment options for and prognosis of children with congenital heart disease. Objective: We combined patient-specific clinical features including diagnosis, age and echocardiographic results, and biomarkers of pulmonary vascular dysfunction to explore the noninvasive methods that can be used to accurately evaluate the reversibility of pulmonary hypertension in congenital heart disease (PH-CHD). Methods: Based on the preoperative systolic pulmonary arterial pressure (sPAP), 70 CHD patients were divided into normal, PH-CHD suspected, and confirmed groups. Additionally, biomarkers of circulating endothelial cells (CECs), endothelin-1 (ET-1), and endothelial nitric oxide synthase (eNOS) were… More
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  • A Rare Case of Late LAD Reimplantation after Arterial Switch Operation
  • Abstract Arterial switch operation (ASO) is a complex neonatal operation in which transfer of the coronary arteries origins is the key to success. Coronary events after a successful ASO are not uncommon. We describe a rare case of a child who underwent an ASO in the neonatal period with one coronary (LAD) described as atretic left in place. At age seven, he developed myocardial ischemia due to retrograde flow with a steal phenomenon from the LAD into the pulmonary artery. The patient underwent a late LAD reimplantation. This case underscores that even very small ostia should be translocated at the time… More
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  • Multi-Institutional US Experience of the Occlutech© AFR Device in Congenital and Acquired Heart Disease
  • Abstract Objectives: To detail the US multi-institutional experience with the Occlutech© (Occlutech International AB, Helsingborg, Sweden) atrial flow regulator (AFR) in children and adults with acquired or congenital heart disease. Background: The creation of a long-term atrial communication is desirable in several cardiovascular disease phenotypes, most notably pulmonary arterial hypertension, disorders of increased left ventricular filling and increased cavopulmonary pressures in patients with a Fontan type circulation. Methods: Patients were identified for inclusion from the AFR device manufacturer database. Data was collected using a RedCap database following IRB approval. 8 weeks of follow up data was sought for each patient based… More
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