Table of Content
- Vol.18, No.1, 2023
- Vol.18, No.2, 2023
- Vol.18, No.3, 2023
- Vol.18, No.4, 2023
- Vol.18, No.5, 2023
- Vol.18, No.6, 2023
- Vol.17, No.1, 2022
- Vol.17, No.2, 2022
- Vol.17, No.3, 2022
- Vol.17, No.4, 2022
- Vol.17, No.5, 2022
- Vol.17, No.6, 2022
- Vol.16, No.1, 2021
- Vol.16, No.2, 2021
- Vol.16, No.3, 2021
- Vol.16, No.4, 2021
- Vol.16, No.5, 2021
- Vol.16, No.6, 2021
- Vol.15, No.1, 2020
- Vol.15, No.2, 2020
- Vol.15, No.3, 2020
- Vol.15, No.4, 2020
- Vol.15, No.5, 2020
- Vol.15, No.6, 2020
- Vol.14, No.1, 2019
- Vol.14, No.2, 2019
- Vol.14, No.3, 2019
- Vol.14, No.4, 2019
- Vol.14, No.5, 2019
- Vol.14, No.6, 2019
- Vol.13, No.1, 2018
- Vol.13, No.2, 2018
- Vol.13, No.3, 2018
- Vol.13, No.4, 2018
- Vol.13, No.5, 2018
- Vol.13, No.6, 2018
- Vol.12, No.1, 2017
- Vol.12, No.2, 2017
- Vol.12, No.3, 2017
- Vol.12, No.4, 2017
- Vol.12, No.5, 2017
- Vol.12, No.6, 2017
About the Journal
Congenital Heart Disease is the first journal focused exclusively on the study and treatment of congenital heart defects in children and adults. It is the official journal of the Children’s Hospital of Nanjing Medical University. We are committed to publishing clinical studies, invited editorials, state-of-the-art reviews, case reports, articles focusing on the history and development of congenital heart disease, and CME material. All manuscripts (including invited) will undergo a rigorous and thorough editorial procedure to promote reliable research findings.
Indexing and Abstracting
Science Citation Index Expanded (Clarivate Analytics): 2023 Impact Factor: 0.3; Scopus CiteScore (Impact per Publication 2023): 0.4; SNIP (Source Normalized Impact per Paper 2023): 0.235; Journal Citation Report/Science Edition (JCR); etc.
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Open Access
ARTICLE
Temporal and Regional Differences in Congenital Heart Surgery in China (2017–2022): Trends and Implications
Congenital Heart Disease, Vol.19, No.4, pp. 341-350, 2024, DOI:10.32604/chd.2024.057403 - 31 October 2024
Abstract Background: With the decline of birth population and the development of medical technology in China, studies assessing how these changes have affected the adoption of congenital heart disease surgery at the national or regional scale are lacking. Methods: We investigated the status of congenital heart surgery in China in the period from 2017–2022, through investigation of the total rates of cardiac surgeries, cardiopulmonary bypass (CPB), adult congenital heart surgeries (CHS), and pediatric CHS (<18 years old), as recorded by the Extracorporeal Circulation Branch of the Chinese Society of Biomedical Engineering. Subsequently, we evaluated correlations between… More >
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Open Access
ARTICLE
Prospective Cohort Research of Aortic Root Dilatation after Surgical Repair in Adults with Tetralogy of Fallot (TRANSIT)
Congenital Heart Disease, Vol.19, No.4, pp. 351-362, 2024, DOI:10.32604/chd.2024.051837 - 31 October 2024
Abstract Background: Aortic root dilatation occurs in adults with tetralogy of Fallot (TOF) after surgical repair, but the longitudinal changes are unclear. The main research aim is to determine the annual dilatation rate of aorta in adults with repaired TOF. Methods: The present, multicentric, prospective cohort study assessed the rate of aortic diameter change in adults aged 20 years or older with TOF, including pulmonary artery atresia, who underwent surgical repair. Clinical data, focusing on echocardiograms, were collected at three-year intervals from seven hospitals. Results: In total, 104 patients (58 males; median age: 29 years) were enrolled.… More >
Graphic Abstract
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Open Access
REVIEW
The Effects of Laser Therapy in Treating Hypertrophic Scars and Keloids after Median Sternotomy: A Scoping Review
Congenital Heart Disease, Vol.19, No.4, pp. 363-374, 2024, DOI:10.32604/chd.2024.053999 - 31 October 2024
Abstract Background: Hypertrophic scars and keloids, common complications following median sternotomy for cardiac surgery, significantly impact patient quality of life due to their aesthetic and symptomatic burden. Recent advancements in laser therapy have made it a prominent option for managing these complex scars, yet a comprehensive understanding of its efficacy is lacking. The aim of this scoping review is to explore the effects of laser therapy in managing hypertrophic scars and keloids after median sternotomy. Methods: This scoping review analyzed studies up to February 2024 from databases including PubMed, EMBASE, CINAHL, Scopus, Web of Science, and… More >
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Open Access
REVIEW
The Potential of Circular RNAs as Biomarkers in Pulmonary Arterial Hypertension Related to Congenital Heart Disease
Congenital Heart Disease, Vol.19, No.4, pp. 375-388, 2024, DOI:10.32604/chd.2024.054742 - 31 October 2024
Abstract A particular type of endogenous noncoding RNAs known as circular RNAs (circRNAs) has now become possible biomarkers for several diseases because of their stability and tissue-specific expression patterns. CircRNAs might play a role in various of biological processes. The identification of particular circRNAs dysregulated in pulmonary arterial hypertension (PAH) raises the possibility of these molecules serving as biomarkers for the disease’s early diagnosis and treatment. This review mainly summarizes the role and potential of circRNA as a future biomarker in PAH related to congenital heart disease. This study presented several potential circRNA targets as diagnostic More >
Graphic Abstract
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Open Access
ARTICLE
Standardized Management of Acute Pulmonary Hemorrhage after Percutaneous Pulmonary Vein Intervention
Congenital Heart Disease, Vol.19, No.4, pp. 389-397, 2024, DOI:10.32604/chd.2024.055121 - 31 October 2024
Abstract Introduction: Pulmonary hemorrhage (PHm) is a life-threatening complication that can occur after catheter-based interventions in patients with pulmonary vein stenosis (PVS). Inhaled racemic epinephrine (iRE) and tranexamic acid (iTXA) have been used in other conditions, but a standardized approach in PVS has not been described. We aimed to describe the current management of PHm after PVS catheter-based interventions. Methods: We present a retrospective review of episodes of PHm from July 2022 to February 2024. PHm was defined as frank blood suctioned from the endotracheal tube including blood-tinged secretions and >3% decrease in saturations and/or ventilatory… More >
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Open Access
LETTER
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Open Access
REVIEW
Right Axillary Thoracotomy Should Be the Standard of Care for Repair of Non-Complex Congenital Heart Defects in Infants and Children
Congenital Heart Disease, Vol.19, No.4, pp. 407-417, 2024, DOI:10.32604/chd.2024.055636 - 31 October 2024
Abstract Minimally invasive approaches for cardiac surgery in children have been lagging in comparison to the adult world. A wide range of the most common congenital heart defects in infants and children can be repaired successfully through a variety of non-sternotomy incisions. This has been shown to be associated with superior cosmetic results, shorter hospital stays, and rapid return to full activity compared to sternotomy. These approaches have been around for decades, but they have not been widely adopted for a variety of reasons. Right axillary thoracotomy is one of these approaches that we believe should More >
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Open Access
REVIEW
Sodium-Glucose Cotransporter 2 Inhibitors in Adult and Pediatric Congenital Heart Disease: Review of Emerging Data and Future Directions
Congenital Heart Disease, Vol.19, No.4, pp. 419-433, 2024, DOI:10.32604/chd.2024.056608 - 31 October 2024
Abstract Heart failure (HF) is common in patients with congenital heart disease (CHD) and there are limited medical therapies. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are a proven medical therapy in patients with acquired HF, though data are limited in patients with CHD. The aim of this review is to summarize the current evidence for use of SGLT2i in patients with CHD and identify future directions for study. In available publications, SGLT2i in patients with CHD seem to be well tolerated, with similar side effect profile to patients with acquired HF. Improvement in functional capacity and natriuretic More >
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Open Access
ARTICLE
Immediate and Long-Term Results of Transcatheter Closure of Patent Ductus Arteriosus—Comparison of Two Decades before and after Change in Antibiotic Infective Endocarditis Prophylaxis Guidelines
Congenital Heart Disease, Vol.17, No.2, pp. 215-230, 2022, DOI:10.32604/CHD.2021.017232
Abstract Objectives: To determine immediate and long-term follow-up of transcatheter closure of patent ductus arteriosus
(PDA) in children. Background: National antibiotic prophylaxis (AP) guideline for infective endocarditis changed after 2009, the effect on practice of PDA closure is unknown. Methods: Observational single center study
analyzing follow-up of PDA closure comparing two time periods before (2002–2009) and after (2010–2019)
changes in AP guideline. Results: 332 patients (68.1% female), median (interquartile range) age 3.0 years
(1.5–5.7) and body weight 14.0 kg (10.0–19.3), were enrolled. PDA morphology was conical type A (50.3%), window type B (1.2%), tubular type C (40.1%), complex type… More >
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Open Access
ARTICLE
Quality of Life in Congenital Heart Disease Patients According to Their Anatomical and Physiological Classification
Congenital Heart Disease, Vol.18, No.2, pp. 197-206, 2023, DOI:10.32604/CHD.2021.013308
Abstract Background: Living well is as important as living longer. The objective of this study is to assess quality of life
(QoL) in congenital heart disease (CHD) according to current AHA/ACC anatomical and physiological classifi-
cation. Methods: Cross-sectional study examining the World Health Organization QoL Bref questionnaire
(WHOQoL-Bref) in consecutive outpatient CHD patients from a single unit. Results: 191 CHD patients were
studied. Median age was 28 ± 13 years and 59% were male. 44 (23%), 115 (60%) and 33 (17%) CHD patients
showed mild, moderate and great anatomical defects respectively while 69 (36%) patients were in physiological… More >
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Open Access
ARTICLE
Modification of Serum Galectin-3 and Reversal of Cardiac Remodeling Following Pediatric Transcatheter Atrial Septal Defect Closure
Congenital Heart Disease, Vol.17, No.2, pp. 173-185, 2022, DOI:10.32604/CHD.2021.016987
Abstract Objectives: We aimed to evaluate the effect of percutaneous atrial septal defect (ASD) closure in children using
right heart indices and serum galectin-3 (Gal-3), as potential biomarkers of right heart remodeling. Methods: This
case–control prospective study included 40 children with ASD and 25 control subjects. An echocardiographic evaluation was performed before the procedure, as well as 24 h, 1 month, and 6 months after intervention. Serum
Gal-3 was measured before, and 1 month after the procedure. Results: Serum Gal-3 concentration, right atrial
(RA) dimensions, right ventricular (RV) dimensions, indexed RA area, and right index of myocardial
performance… More >
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Open Access
ARTICLE
The Glenn Shunt Revisited, A Single Center Registry in Ain Shams University Cardiology Department
Congenital Heart Disease, Vol.17, No.1, pp. 71-85, 2022, DOI:10.32604/CHD.2022.018372
Abstract Background: Bidirectional Glenn shunts have long been available as palliative procedures for patients with single ventricle physiology that is, patients unsuitable for biventricular repair. In our country they are performed at an older age than that recommended by the literature. So, we aim to assess post bidirectional Glenn shunt patients to detect the presence of any complications and to evaluate their functional capacity. Methods: This was a descriptive study that included all patients who underwent a bidirectional Glenn shunt and were referred for follow up in Ain shams university hospitals. History taking including NYHA class and… More >
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Open Access
ARTICLE
Characteristics of In-Hospital Patients with Congenital Heart Disease Requiring Rapid Response System Activations: A Japanese Database Study
Congenital Heart Disease, Vol.17, No.1, pp. 31-43, 2022, DOI:10.32604/CHD.2022.017407
Abstract Objectives: This study aimed to study the characteristics of in-hospital deterioration in patients with congenital heart
disease who required rapid response system activation and identify risk factors associated with 1-month mortality.
Methods: We retrospectively analysed data from a Japanese rapid response system registry with 35 participating hospitals. We included consecutive patients with congenital heart disease who required rapid response system activation
between January 2014 and March 2018. Logistic regression analyses were performed to examine the associations
between 1-month mortality and other patient-specific variables. Results: Among 9,607 patients for whom the rapid
response system was activated, only 82… More >
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Open Access
REVIEW
Prevalence of Bicuspid Aortic Valve in Turner Syndrome Patients Receiving Cardiac MRI and CT: A Meta-Analysis
Congenital Heart Disease, Vol.17, No.2, pp. 129-141, 2022, DOI:10.32604/CHD.2022.018300
Abstract Turner syndrome (TS) is a rare disorder affecting 25–50 in 100000 female newborns. Bicuspid aortic valve (BAV)
is assumed to be the most common congenital heart defect (CHD) in TS. In literature, reported BAV prevalence in
TS ranges between 14% and 34%. The specific BAV prevalence in TS is still unknown. The aim of this study was to
give a more precise estimation of BAV prevalence in TS by conducting a meta-analysis of TS-studies, which
detected BAV by either cardiac magnetic resonance imaging (MRI) or cardiac computed tomography (CT).
We searched PubMed, Cochrane Library, and… More >
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Open Access
REVIEW
The Relationship between T-Wave Alternans and Adverse Cardiac Events in Patients with Congenital Long QT Syndrome: A Systematic Review and Meta-Analysis
Congenital Heart Disease, Vol.17, No.5, pp. 557-567, 2022, DOI:10.32604/CHD.2021.017292
Abstract Background: T-wave alternans (TWA) is a risk factor of ventricular arrhythmias or sudden cardiac death (SCD)
in patients with ischemic cardiomyopathy. Nevertheless, the relationship between TWA and adverse cardiac
events (ACE) in patients with congenital long QT syndrome (LQT) remains controversial. Methods: A systematic
electronic search of PubMed, Embase and the Cochrane Library was conducted from database inception dates to
28 April 2021 and assessed the relationship between TWA and ACE in patients with LQTS. Sub-group analysis
evaluated the association between microvolt TWA (MTWA) and ACE in different monitoring models and ECGlead numbers. Results: A pooled analysis… More >
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Open Access
ARTICLE
Preoperative Feeding in Single Ventricle Neonates is Predictive of Shorter Time to Goal Feed
Congenital Heart Disease, Vol.17, No.5, pp. 505-518, 2022, DOI:10.32604/chd.2022.021571
Abstract Background: Patients with single ventricle anatomy are at increased risk of growth failure and malnutrition.
Amongst cardiac centers, there is little standardization of feeding practices in this complex population. We
hypothesized that initiation of our center’s preoperative feeding protocol would result in decreased gastrostomy
tube (G-tube) use, decreased length of stay and would not result in increased Necrotizing Enterocolitis (NEC)
rates. Methods: A single institution review of 52 patients who had undergone stage I single ventricle palliative
repair was performed. Patient diagnoses were hypoplastic left heart syndrome (39%), atrioventricular canal
(15%), and other (46%). Postoperative parameters such… More >
Graphic Abstract
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Open Access
ARTICLE
Pulmonary Perfusion Asymmetry in Patients after Repair of Tetralogy of Fallot: A 4D Flow MRI-Based Study
Congenital Heart Disease, Vol.17, No.2, pp. 117-128, 2022, DOI:10.32604/chd.2022.018779
Abstract Background: Repaired Tetralogy of Fallot (rTOF) patients may have residual lesions such as main (MPA) and branch pulmonary artery stenosis (BPAS). While MPA stenosis is well studied, few data are available on BPAS in rTOF. We aimed to describe pulmonary perfusion in a large paediatric cohort of rTOF and its impact on right ventricular and outflow-tract hemodynamics using 4D flow CMR. Methods: 130 consecutive patients (mean age at CMR 14.3 ± 4.6 years) were retrospectively reviewed. 96 patients had transannular patch without valve preservation while 34 patients had conserved annulus or valved conduit. A pulmonary blood flow ratio… More >
Graphic Abstract
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Open Access
REVIEW
Ductus Arteriosus Stent Compared with Surgical Shunt for Infants with Ductal-Dependent Pulmonary Blood Flow: A Systematic Review and Meta-Analysis
Congenital Heart Disease, Vol.17, No.1, pp. 45-60, 2022, DOI:10.32604/CHD.2022.016332
Abstract The aim of this study was to perform a systematic review and meta-analysis to evaluate the safety and efficacy of
ductus arteriosus stent (DAS) compared with surgical systemic-pulmonary artery shunt (SPS) in patients with
ductal-dependent pulmonary blood flow. A literature search was conducted in PubMed, Embase, and the
Cochrane Library databases from their inception to December 2020. Two reviewers independently screened
the articles, evaluated the quality of the articles, and collected the data. Meta-analyses were conducted using fixed
and random effects models. We used the I-square (I2
) test to examine heterogeneity and the funnel plot… More >
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Open Access
ARTICLE
Surgical Correction of Coronary Artery Ectasia Combining Congenital Coronary Artery Fistula
Congenital Heart Disease, Vol.16, No.1, pp. 95-106, 2021, DOI:10.32604/CHD.2021.014276
Abstract Background: Coronary artery ectasia (CAE) complicated with concomitant congenital coronary artery fistula (CCAF) is rare. This study characterizes the clinical characteristics of CAE combining CCAF, and reports a single-institution experience with surgical correction of CAE combining CCAF. Methods: A total of 24 symptomatic patients (8 males, median 52.5 years old) who underwent surgical correction of CAE combining CCAF in this center were reviewed. Based on the size of ectatic segment, the CAE were classified as a giant CAE (>20 mm, n = 14) and a non-giant CAE (≤20 mm, n = 10). Individualized surgical approaches were… More >
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Open Access
ARTICLE
Kabuki-Syndrome and Congenital Heart Disease—A Twenty-Year Institutional Experience
Congenital Heart Disease, Vol.16, No.2, pp. 171-181, 2021, DOI:10.32604/CHD.2021.014409
Abstract Background: Patients with genetic syndromes who undergo surgery to correct congenital heart defects can be at risk for increased morbidity or mortality. Surgical outcomes and postoperative courses following congenital heart surgery in patients with Kabuki-Syndrome (KS) have not been well studied. Objectives: The purpose of this study was to describe the postoperative courses and associated outcomes in the largest set of KS patients undergoing congenital heart surgery to date. Methods: Patients with a confirmed molecular diagnosis of KS and a diagnosis of a CHD admitted to Texas Children’s Hospital between January 1, 2000 and January 1, 2020… More >
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Open Access
REVIEW
Important Newborn Cardiac Diagnostic Dilemmas for the Neonatologist and Cardiologist–A Clinical Perspective
Congenital Heart Disease, Vol.16, No.2, pp. 189-196, 2021, DOI:10.32604/CHD.2021.014903
Abstract Most congenital heart disease (CHD) is readily recognisable in the newborn. Forewarned by previous fetal scanning, the presence of a murmur, tachypnoea, cyanosis and/or differential pulses and saturations all point to a cardiac abnormality. Yet serious heart disease may be missed on a fetal scan. There may be no murmur or clinical cyanosis, and tachypneoa may be attributed to non-cardiac causes. Tachypnoea on day 1 is usually non-cardiac except arising from ventricular failure or a large systemic arteriovenous fistula. A patent ductus arteriosus (PDA) may support either pulmonary or systemic duct dependent circulations. The initially… More >
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Open Access
ARTICLE
Selexipag as Add-on Therapy for Patients with Pulmonary Arterial Hypertension Associated with Congenital Heart Disease: A Single-Center Retrospective Study
Congenital Heart Disease, Vol.16, No.3, pp. 233-244, 2021, DOI:10.32604/CHD.2021.014272
Abstract Purpose: This study examined the efficacy and safety of selexipag in treating pulmonary arterial hypertension (PAH) associated with congenital heart disease (CHD). Materials and Methods: We conducted a retrospective study of patients with CHD-associated PAH, treated with selexipag since December 2017. Thirteen adult patients (mean age, 45.4 years; women, 77%) were treated with selexipag as add-on therapy. Baseline characteristics, World Health Organization functional class, 6-minute walking distance (6MWD) test results, N-terminal pro-B-type natriuretic peptide levels, echocardiographic data, and incidence of side effects were assessed. Results: The majority of patients (12/13, 92.3%) experienced more than one treatment-associated complication;… More >
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Open Access
ARTICLE
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Open Access
CASE REPORT
Management of “Wall to Wall Heart” in a Transient Neonatal Tricuspid Regurgitation
Congenital Heart Disease, Vol.16, No.3, pp. 205-210, 2021, DOI:10.32604/CHD.2021.015371
Abstract We present a case of a one-day-old newborn, without prenatal diagnosis, referred to our cardiologic intensive care unit in critical condition presenting sub-cyanosis and peripheral oxygen saturation of 80%. Echocardiography diagnosis was tricuspid valve dysplasia with severe regurgitation, functional pulmonary valve atresia with intact ventricular septum and reversal flow in the large patent ductus arteriosus (PDA). Chest X-ray showed severe cardiomegaly and wall to wall heart. Prostaglandin E1 infusion was started once after birth. After few days, clinical conditions progressively worsened because of right heart failure; a first pharmacological approach to close PDA failed and More >
Copyright © 2024 The Author(s). Published by Tech Science Press.
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