CHDOpen Access

Congenital Heart Disease

ISSN:1747-079X(print)
ISSN:1747-0803(online)
Publication Frequency:Bi-monthly

  • Online
    Articles

    1629

  • on board
    editors

    64



About the Journal

Congenital Heart Disease is the first journal focused exclusively on the study and treatment of congenital heart defects in children and adults. We are committed to publishing research articles, reviews, editorials, guidelines and case reports (mainly by invitation). All manuscripts (including invited) will undergo a rigorous and thorough editorial procedure to promote reliable research findings.

Indexing and Abstracting

Science Citation Index Expanded (Clarivate Analytics): 2021 Impact Factor: 2.419; Scopus CiteScore (Impact per Publication 2021): 4.0; SNIP (Source Normalized Impact per Paper 2021): 1.268; Journal Citation Report/Science Edition (JCR); etc.

  • Open Access

    ARTICLE

    Ventricular Septal Crypts: Remnants of Spontaneous Interventricular Defect Closure?

    Congenital Heart Disease, Vol.18, No.1, pp. 1-6, 2023, DOI:10.32604/chd.2023.025639
    Abstract Background: Ventricular crypts are quite a common finding during cardiac imaging, but their etiology is unclear. A possible final result of a spontaneous ventricular septal defect closure has been supposed but never investigated in earlier studies. Method: From January 1997 to December 2020, all newborns diagnosed to have a ventricular septal defect were prospectively entered in our database and those with an isolated defect were included in the study. Ventricular septal defects were classified into four types: perimembranous, trabecular muscular, inlet and outlet. A long-term follow up was performed in order to visualize the possible residual formation of a septal… More >

    Graphic Abstract

    Ventricular Septal Crypts: Remnants of Spontaneous Interventricular Defect Closure?

  • Open Access

    ARTICLE

    Genetic Analysis of Variants of the MYH6 Gene Promoter in Congenital Atrial Septal Defects

    Congenital Heart Disease, Vol.18, No.1, pp. 7-21, 2023, DOI:10.32604/chd.2022.025451
    Abstract Background: Atrial septal defect (ASD) is one of the common congenital heart diseases. The MYH6 gene has a critical role in cardiac development but the role of MYH6 promoter variants in patients with ASD has not been explored. Methods: In 613 subjects including 320 ASD patients, we investigated the MYH6 gene promoter variants and verified the effect on gene expression by using cellular functional experiments and bioinformatics analysis. Results: Eleven variants were identified in the MYH6 gene promoter, of which four variants were found only in ASD patients, and two variants (g.3434G>C and g.4524C>T) were identified for the first time.… More >

    Graphic Abstract

    Genetic Analysis of Variants of the <i>MYH6</i> Gene Promoter in Congenital Atrial Septal Defects

  • Open Access

    ARTICLE

    Preoperative Fasting of More Than 14 Hours Increases the Risk of Time-to-Death after Cardiothoracic Surgery in Children: A Retrospective Cohort Study

    Congenital Heart Disease, Vol.18, No.1, pp. 23-39, 2023, DOI:10.32604/chd.2023.026026
    Abstract Background: Prolonged preoperative fasting can cause hypoglycemia, hyperglycemia, and intravascular volume depletion in children. We aimed to examine whether prolonged preoperative fasting is associated with in-hospital mortality and other morbidities in pediatric cardiothoracic surgery. Methods: This retrospective cohort study included children aged 0–3 years who underwent cardiac surgery between July 2014 and October 2020. The patient demographic data, surgery-related and anesthesia-related factors, and postoperative outcomes, including hypoglycemia, hyperglycemia, sepsis, length of intensive care unit stay, and in-hospital mortality, were recorded. The main exposure and outcome variables were prolonged fasting and time-to-death after surgery, respectively. The associations between prolonged fasting and… More >

    Graphic Abstract

    Preoperative Fasting of More Than 14 Hours Increases the Risk of Time-to-Death after Cardiothoracic Surgery in Children: A Retrospective Cohort Study

  • Open Access

    ARTICLE

    Preliminary Evaluation of Hemodynamic Effects of Fontan Palliation on Renal Artery Using Computational Fluid Dynamics

    Congenital Heart Disease, Vol.18, No.1, pp. 41-55, 2023, DOI:10.32604/chd.2023.025005
    Abstract Background: The assessment of renal function is important to the prognosis of patients needing Fontan palliation due to the reconstructed compromised circulation. To know the relationship between the kidney perfusion and hemodynamic characteristics during surgical design could reduce the risk of acute kidney injury (AKI) and the postoperative complications. However, the issue is still unsolved because the current clinical evaluation methods are unable to predict the hemodynamic changes in renal artery (RA). Methods: We reconstructed a three-dimensional (3D) vascular model of a patient requiring Fontan palliation. The technique of computational fluid dynamics (CFD) was utilized to explore the changes of… More >

    Graphic Abstract

    Preliminary Evaluation of Hemodynamic Effects of Fontan Palliation on Renal Artery Using Computational Fluid Dynamics

  • Open Access

    CASE REPORT

    Emergency Hybrid Correction in a Newborn with Critical Aortic Valve Stenosis with Acute Pulmonary Edema in the First Hour after Birth

    Congenital Heart Disease, Vol.18, No.1, pp. 57-65, 2023, DOI:10.32604/chd.2023.025522
    (This article belongs to this Special Issue: Nightmare Case Reports in Congenital Heart Disease)
    Abstract Critical aortic valve stenosis in newborns is the cause of a severe clinical condition with the onset of symptoms during first hours after birth. We present a clinical case of a successful surgical correction of a critical aortic stenosis using a hybrid method applied in a newborn during the first day of life. The infant was diagnosed with a hypoplastic left heart complex with an intact atrial septum (aortic and mitral valves stenosis variant), that led to the cardiogenic shock and acute pulmonary edema. The procedure included bilateral banding of the pulmonary artery branches and atrioseptostomy with stenting of the… More >

    Graphic Abstract

    Emergency Hybrid Correction in a Newborn with Critical Aortic Valve Stenosis with Acute Pulmonary Edema in the First Hour after Birth

  • Open Access

    CASE REPORT

    “Treat-Repair-Treat”: Management of Left Main Coronary Compression by a Pulmonary Artery Aneurysm in a Patient with Atrial Septal Defect and Significant Pulmonary Hypertension

    Congenital Heart Disease, Vol.18, No.1, pp. 67-72, 2023, DOI:10.32604/chd.2023.026598
    (This article belongs to this Special Issue: Nightmare Case Reports in Congenital Heart Disease)
    Abstract Left main coronary compression syndrome (LMCS) may complicate pulmonary artery aneurysms (PAA), usually developed in the context of pulmonary arterial hypertension (PAH). We report the case of a 51-year-old female patient with an atrial septal defect (unsuitable for device closure) complicated by a PAA generating a 90% left main stenosis. The significant PAH held us back from immediate surgery. After specific dual PAH-targeted therapy (sildenafil and bosentan), the atrial septal defect could be closed with a unidirectional valved patch; the PAA-induced LMCS was treated by reductive arterioplasty. The postoperative course was uneventful. Follow-up showed clinical improvement, but PAH treatment was… More >

    Graphic Abstract

    “Treat-Repair-Treat”: Management of Left Main Coronary Compression by a Pulmonary Artery Aneurysm in a Patient with Atrial Septal Defect and Significant Pulmonary Hypertension

  • Open Access

    CASE REPORT

    Pentalogy of Cantrell with Pentalogy of Fallot and Left Ventricular Diverticulum

    Congenital Heart Disease, Vol.18, No.1, pp. 73-78, 2023, DOI:10.32604/chd.2023.026404
    (This article belongs to this Special Issue: Nightmare Case Reports in Congenital Heart Disease)
    Abstract Pentalogy of Cantrell is a congenital anomaly characterized by a combination of birth defects involving the sternum, diaphragm, pericardium, abdominal wall, and heart. Pentalogy of Cantrell is a rare anomaly with high mortality. This paper describes the treatment of a 9-month-old girl with pentalogy of Cantrell, pentalogy of Fallot, and left ventricular diverticulum. The patient is alive and well 13 years after surgery. More >

  • Open Access

    ARTICLE

    Early Cardiac Catheterizations within 30 Days Post Congenital Heart Surgery in Children

    Congenital Heart Disease, Vol.18, No.1, pp. 79-95, 2023, DOI:10.32604/chd.2022.022401
    Abstract Background: This study set out to assess the indications, feasibility, safety, and outcome of early cardiac catheterizations (CC) within 30 days after congenital heart surgery (CHS) in children. Methods and Results: This is a retrospective, single-center case review study of all CC within 30 days after CHS between 1/2010-12/2020. A total of 317 (138 diagnostic, 179 interventional) CC were performed in 245 patients at a median of 4 days (IQR 13) after CHS. The median age was 3 months (IQR 6), and body weight was 5 kg (IQR 4). A total of 194 (61.2%) CC were performed in patients with… More >

  • Open Access

    ARTICLE

    Classifying Cardiac Anomalies in Right and Left Isomerism: Concordant and Discordant Patterns

    Congenital Heart Disease, Vol.18, No.1, pp. 97-111, 2023, DOI:10.32604/chd.2022.023619
    Abstract Aims: Evidence is emerging that, in the setting of isomerism, the atrial and bronchial arrangement are not always concordant, nor are these patterns always harmonious with the arrangement of the abdominal organs. We aimed to evaluate the concordance between these features in a cohort of patients with cardiac malformations in the setting of known isomerism, seeking to determine whether it was feasible to assess complexity on this basis, in this regard taking note of the potential value of bronchial as opposed to appendage morphology. Methods and Results: We studied 78 patients known to have isomerism of the bronchuses, 43 with… More >

    Graphic Abstract

    Classifying Cardiac Anomalies in Right and Left Isomerism: Concordant and Discordant Patterns

  • Open Access

    ARTICLE

    Assessment of Intracardiac and Extracardiac Deformities in Patients with Various Types of Pulmonary Atresia by Dual-Source Computed Tomography

    Congenital Heart Disease, Vol.18, No.1, pp. 113-125, 2023, DOI:10.32604/chd.2023.023542
    Abstract Background: Pulmonary atresia (PA) is a group of heterogeneous complex congenital heart disease. Only one study modality might not get a correct diagnosis. This study aims to investigate the diagnostic power of dual-source computed tomography (DSCT) for all intracardiac and extracardiac deformities in patients with PA compared with transthoracic echocardiography (TTE). Materials and Methods: This retrospective study enrolled 79 patients and divided them into three groups according to their main diagnosis. All associated malformations and clinical information, including treatments, were recorded and compared among the three groups. The diagnostic power of DSCT and TTE on all associated malformations were compared.… More >

    Graphic Abstract

    Assessment of Intracardiac and Extracardiac Deformities in Patients with Various Types of Pulmonary Atresia by Dual-Source Computed Tomography

Share Link

WeChat scan