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ABSTRACT

Flow and Deformation in Externally Pressurized Stenosis Model of Arterial Disease

S. Kobayashi1, J. Ji1, H. Morikawa1, D. Tang2, D. N. Ku3
Department of Functional Machinery and Mechanics, Faculty of Textile Science and Technology, Shinshu University, Tokida, Ueda, Nagano 386–8567, Japan
Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609, USA
School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332–0363, USA

The International Conference on Computational & Experimental Engineering and Sciences 2008, 6(3), 169-174. https://doi.org/10.3970/icces.2008.006.169

Abstract

The increase of the blood velocity in the distal side of the stenosis causes negative transmural pressure, and atheroscrerotic plaque is compressed, furthermore, the stenosis may cause the collpase which leads the rupture of the plaque. The resultant compression may be important in the development of atherosclerotic plaque fracture and subsequent thrombosis or distal embolization. We have developed stenosis models made of polyvinyl alcohol hydrogel, which closely approximate an arterial disease situation, and performed pulsatile flow experiments. Valsalva's maneuver and cough cause a sharp rise in jugular venous pressure to greater than 50 mmHg. Such transient pressure increases within the carotid sheath may augment the external pressure around the carotid artery. We applied external pressure to a stenosis model and discussed the influences of external pressure on steady and pulsatile flow and deformation in the stenosis model.

Cite This Article

Kobayashi, S., Ji, J., Morikawa, H., Tang, D., Ku, D. N. (2008). Flow and Deformation in Externally Pressurized Stenosis Model of Arterial Disease. The International Conference on Computational & Experimental Engineering and Sciences, 6(3), 169–174.



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