Open Access

ABSTRACT

in silico Method for the Identification of Mycobacterial sp. Potential Drug Targets

by Ashutosh Singh¹, Shruti Mishra², Dhwani Raghav¹, Vinay Sharma¹

1 Faculty of Life Sciences, Department of Bio techgnology, Banasthali University, Banasthali, Rajasthan, India. Email: ashutosh.bio@gmail.com
2 Research Associate, Biobase, Banglore, India.

The International Conference on Computational & Experimental Engineering and Sciences 2008, 6(2), 119-124. https://doi.org/10.3970/icces.2008.006.119

Abstract

Drug resistance has increased the pace of war against the ever-growing challenge of mycobacterial infections particularly with the growing menace of tuberculosis (TB).Previous studies reported several essential and virulent genes of mycobacterium like virS gene and mymA operon[1] through experimental approaches. However, Post genomic approach applied for the identification of targets for tuberculosis which includes the comparison of Mycobacterium tuberculosis CDC1551 proteome against database of essential genes and proteome of Homo sapiens. A total of approx 4000 proteins were studied and compared and 19 proteins were found to possess potentiality to call as Targets.

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