Experimental and Computational Elucidation of Mechanical Forces on Cell Nucleus
Miao Huang1, Maedeh Lotfi1, Heyang Wang4, Hayley Sussman5, Kevin Connell1, Quang Vo1, Malisa Sarntinoranont1, Hitomi Yamaguchi1, Juan Guan2, Xin Tang1,3,*
The International Conference on Computational & Experimental Engineering and Sciences, Vol.32, No.1, pp. 1-2, 2024, DOI:10.32604/icces.2024.011130
Abstract Mechanotransduction, i.e., living cells sense and transduce mechanical forces into intracellular biochemical signaling and gene expression, is ubiquitous across diverse organisms. Increasing evidence suggests that mechanotransduction significantly influences cell functions and its mis-regulation is at the heart of various pathologies. A quantitative characterization of the relationship between mechanical forces and resulted mechanotransduction is pivotal in understanding the rules of life and innovating new therapeutic strategies [1-3]. However, while such relationship on the cell surface membrane and cytoskeleton have been well studied, little is known about whether/how mechanical forces applied on the cell interior nucleus (“headquarter… More >