Open Access

ARTICLE

Oxygen Transport in Tissue Engineering Systems: Cartilage and Myocardium

by B. Obradovic¹, M. Radisic², G. Vunjak-Novakovic³

1 Faculty of Technology and Metallurgy, Belgrade University, Belgrade, Serbia
2 University of Toronto, Toronto, Ontario, Canada
3 Columbia University, New York, NY, U.S.A.

Fluid Dynamics & Materials Processing 2007, 3(3), 189-202. https://doi.org/10.3970/fdmp.2007.003.189

Abstract

Efficient transport of oxygen is one of the main requirements in tissue engineering systems in order to avoid cell death in the inner tissue regions and support uniform tissue regeneration. In this paper, we review approaches to design of tissue engineering systems with adequate oxygen delivery for cultivation of cartilage and myocardium, two distinctly different tissue types with respect to the tissue structure and oxygen requirements. Mathematical modeling was used to support experimental results and predict oxygen transport within the cultivated tissues and correlate it to the cell response and tissue properties.

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Keywords

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