Artificial intelligence (AI) and related domains like machine learning and deep learning have risen in recent years. Applications of AI-based technologies in healthcare are enormous and ranges from simple data analysis to complex disease prediction and precision medicine development. The digitisation of health records in the form of Electronic Health Records (EHRs) that store the patient records and other details like lab results, medications and other historical data has provided a platform for utilising these details using AI-based techniques for delivering deep insight to patient information and present a detailed analysis and predictive capability. Also, the rise in the Internet of Things (IoT) applications for sensing and monitoring the patients continuously also helped get more details and information in real-time. These applications of IoT is generally referred to as the Internet of Medical Things (IoMT). Several other related technologies like fog computing, edge computing and data analytics, and traditional cloud computing applications are also being used actively for medical and healthcare domains to record the patient details and further process them for diagnosis and provide intelligent healthcare solutions. Security and privacy of records are also a severe concern in situations where personal and critical information are being recorded, and various transactions on these records are taking place. Blockchain is a novel solution for providing secure transactions and assuring private and immutable records. Medical and healthcare have a massive opportunity for blockchain application in each healthcare domain and is being actively used by researchers to propose a different solution. This special issue tries to present the latest trends and applications of digital innovations in the domain of healthcare and provide a futuristic approach for various applications and solutions in the field of digital healthcare.