Open Access


DNA Sequence Analysis for Brain Disorder Using Deep Learning and Secure Storage

Ala Saleh Alluhaidan*
Departmemt of Information Systems, College of Computer and Information Science, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia
* Corresponding Author: Ala Saleh Alluhaidan. Email:

Computers, Materials & Continua 2022, 71(3), 5949-5962.

Received 25 July 2021; Accepted 25 November 2021; Issue published 14 January 2022


Analysis of brain disorder in the neuroimaging of Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET), and Computed Tomography (CT) needs to understand the functionalities of the brain and it has been performed using traditional methods. Deep learning algorithms have also been applied in genomics data processing. The brain disorder diseases of Alzheimer, Schizophrenia, and Parkinson are analyzed in this work. The main issue in the traditional algorithm is the improper detection of disorders in the neuroimaging data. This paper presents a deep learning algorithm for the classification of brain disorder using Deep Belief Network (DBN) and securely storing the image using a Deoxyribonucleic Acid (DNA) Sequence-based Joint Photographic Experts Group (JPEG) Zig Zag Encryption Algorithm (DBNJZZ). In this work, DBNJZZ implements an efficient and effective prediction model for disorders using the open-access datasets of Alzheimer's Disease Neuroimaging Initiative (Adni), the Center for Biomedical Research Excellence (Cobre), the Open Access Series of Imaging Studies (Oasis), the Function Biomedical Informatics Research Network (Fbirn), a Parkinson's dataset of 55 patients and 23 subjects with Parkinson's syndromes (Ntua), and the Parkinson's Progression Markers Initiative (Ppmi). This algorithm is implemented and tested using performance metric measures of accuracy, Root Mean Square Error (RMSE), Mean Absolute Error (MAE), and Mean Absolute Percentage Error (MAPE). DBNJZZ gives better performance with an accuracy of 99.21% and also surpasses previous methods on other measures.


DBN; Zig zag; deep learning; MAPE; RMSE; DNA; genomics

Cite This Article

A. Saleh Alluhaidan, "Dna sequence analysis for brain disorder using deep learning and secure storage," Computers, Materials & Continua, vol. 71, no.3, pp. 5949–5962, 2022.

This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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