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Case Report: Laubry-Pezzi Syndrome: Confronting the Lethal Nexus of Life-Threatening Complications in Resource Constrained Settings

by Hayatu Uma1,*, Abdulaziz Aminu1, Raghu Cherukupalli2, Femi Akindotun Akintomide1, Abdul Habu3, Aisha Aminu Lawal1, Adamu Mohammad1

1 Department of Internal Medicine, Usmanu Danfodiyo University Teaching Hospital, Sokoto, 23270, Nigeria
2 Cardiovascular Division, Aster Prime Hospitals, Hyderabad, 500038, India
3 Department of Internal Medicine, Federal Medical Center Nguru, Nguru, 630261, Yobe, Nigeria

* Corresponding Author: Hayatu Uma. Email: email

Congenital Heart Disease 2024, 19(6), 635-645. https://doi.org/10.32604/chd.2025.056641

Abstract

Laubry-Pezzi syndrome (L-PS) is a rare congenital heart disease characterized by a ventricular septal defect (VSD) and aortic valve prolapse. These cardiac lesions predispose individuals to infective endocarditis (IE), a life-threatening complication, especially in resource-constrained settings. A 17-year-old male presented with a three-week history of fever and headache, and a one-week history of abdominal pain, vomiting, and diarrhea. On presentation, he appeared toxic, was febrile, tachypneic, tachycardic, and blood pressure of 120/30 mmHg, and heart sounds were S1, S2. Abdominal examination revealed generalized tenderness. A provisional diagnosis of typhoid sepsis with intestinal perforation was considered. However, a thorough clinical evaluation led to the definitive diagnosis of L-PS complicated by right-sided IE, sepsis, acute kidney injury, acute heart failure, and haemoptysis. Despite significant improvement with appropriate antibiotics and adjunctive therapy, the patient’s inability to afford surgical correction and subsequent non-adherence to medical advice he resorted to traditional medicine this led to readmission for heart failure. This case highlights the diagnostic and treatment challenges associated with L-PS with life-threatening complications, particularly in resource-constrained settings, where it may be misdiagnosed as common infections like typhoid sepsis with intestinal perforation. It emphasizes the importance of a comprehensive clinical approach, including a detailed history, meticulous physical examination, and targeted investigations, to ensure accurate diagnosis and timely intervention in patients with L-PS and its life-threatening complications.

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APA Style
Uma, H., Aminu, A., Cherukupalli, R., Akintomide, F.A., Habu, A. et al. (2024). Case report: laubry-pezzi syndrome: confronting the lethal nexus of life-threatening complications in resource constrained settings. Congenital Heart Disease, 19(6), 635–645. https://doi.org/10.32604/chd.2025.056641
Vancouver Style
Uma H, Aminu A, Cherukupalli R, Akintomide FA, Habu A, Lawal AA, et al. Case report: laubry-pezzi syndrome: confronting the lethal nexus of life-threatening complications in resource constrained settings. Congeni Heart Dis. 2024;19(6):635–645. https://doi.org/10.32604/chd.2025.056641
IEEE Style
H. Uma et al., “Case Report: Laubry-Pezzi Syndrome: Confronting the Lethal Nexus of Life-Threatening Complications in Resource Constrained Settings,” Congeni. Heart Dis., vol. 19, no. 6, pp. 635–645, 2024. https://doi.org/10.32604/chd.2025.056641



cc Copyright © 2024 The Author(s). Published by Tech Science Press.
This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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