Cardiac Rehabilitation by Pulmonary Artery Banding after Induced Dilated Cardiomyopathy: A Pilot Study on a Rodent Model
Domenico Crea1, Arben Dedja1, Matteo Ponzoni1,2, Stefania Rizzo3, Alberto Cipriani4, Riccardo Bariani4, Kalliopi Pilichou3, Maria Bueno Marinas3, Danila Azzolina5, Massimo A. Padalino1,6,*
Congenital Heart Disease, Vol.19, No.5, pp. 473-487, 2024, DOI:10.32604/chd.2025.057014
- 31 December 2024
Abstract Background: Since 2015, the pulmonary artery banding (PAB), following the Giessen protocol, has treated end-stage heart failure in selected infants with preserved right ventricular function, acting as a bridge to transplant or recovery, as a result of ventricular-ventricular interaction. Objectives: To elucidate whether PAB is a feasible and reproducible procedure in a rodent model of pharmacologically induced dilated cardiomyopathy (DCM) and to evaluate PAB-induced ventricular rehabilitation. Methods: We used 49 Sprague-Dawley rats divided into four groups: a sham surgery control group, a healthy animal group undergoing PAB, a doxorubicin (DOX)- treated control group, and a DOX… More >