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Sodium-Glucose Cotransporter 2 Inhibitors in Adult and Pediatric Congenital Heart Disease: Review of Emerging Data and Future Directions

William H. Marshall V1,2,*, Lydia K. Wright2

1 Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
2 The Heart Center, Nationwide Children’s Hospital, Columbus, OH 43205, USA

* Corresponding Author: William H. Marshall V. Email: email

Congenital Heart Disease 2024, 19(4), 419-433. https://doi.org/10.32604/chd.2024.056608

Abstract

Heart failure (HF) is common in patients with congenital heart disease (CHD) and there are limited medical therapies. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are a proven medical therapy in patients with acquired HF, though data are limited in patients with CHD. The aim of this review is to summarize the current evidence for use of SGLT2i in patients with CHD and identify future directions for study. In available publications, SGLT2i in patients with CHD seem to be well tolerated, with similar side effect profile to patients with acquired HF. Improvement in functional capacity and natriuretic peptides are mixed, though there is a signal for potential reduction in HF hospitalizations. One prospective study in patients with systemic right ventricles showed an improvement in systolic function for patients already on maximal HF medical therapy. Though limited, there is emerging data on use of SGLT2i in pediatric patients with CHD and HF. Future prospective studies are needed to evaluate for clinically meaningful endpoints, including HF hospitalization, as well as evaluate the hemodynamic impact in subtypes of CHD at high risk for HF.

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APA Style
V, W.H.M., Wright, L.K. (2024). Sodium-glucose cotransporter 2 inhibitors in adult and pediatric congenital heart disease: review of emerging data and future directions. Congenital Heart Disease, 19(4), 419-433. https://doi.org/10.32604/chd.2024.056608
Vancouver Style
V WHM, Wright LK. Sodium-glucose cotransporter 2 inhibitors in adult and pediatric congenital heart disease: review of emerging data and future directions. Congeni Heart Dis. 2024;19(4):419-433 https://doi.org/10.32604/chd.2024.056608
IEEE Style
W.H.M. V and L.K. Wright, “Sodium-Glucose Cotransporter 2 Inhibitors in Adult and Pediatric Congenital Heart Disease: Review of Emerging Data and Future Directions,” Congeni. Heart Dis., vol. 19, no. 4, pp. 419-433, 2024. https://doi.org/10.32604/chd.2024.056608



cc Copyright © 2024 The Author(s). Published by Tech Science Press.
This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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