Risk Stratification and Prognosis of Pulmonary Arterial Hypertension Associated with Congenital Heart Disease
Wenjie Dong1,2,#, Zhibin Hong1,#, Aqian Wang2, Kaiyu Jiang2, Hai Zhu2, Fu zhang2, Zhaoxia Guo2, Hongling Su2,*, Yunshan Cao3,*
Congenital Heart Disease, Vol.19, No.3, pp. 325-339, 2024, DOI:10.32604/chd.2024.052267
- 26 July 2024
(This article belongs to the Special Issue: Interventional therapy of congenital heart disease: past, now, and future)
Abstract Background: Current guidelines for managing pulmonary arterial hypertension (PAH) recommend a risk stratification approach. However, the applicability and accuracy of these strategies for PAH associated with congenital heart disease (PAH-CHD) require further validation. This study aims to validate the reliability and predictive accuracy of a simplified stratification strategy for PAH-CHD patients over a three-year follow-up. Additionally, new prognostic variables are identified and novel risk stratification methods are developed for assessing and managing PAH-CHD patients. Methods: This retrospective study included 126 PAH-CHD patients. Clinical and biochemical variables across risk groups were assessed using Kruskal-Wallis and Fisher’s… More >
Graphic Abstract