Open Access
ARTICLE
Dynamic Changes in Left and Right Cerebral Oxygen Saturation during Selective Cerebral Perfusion in Young Infants
Hwa-Young Jang1, Sang-Jun Beon2, Sung-Hoon Kim1, In-Kyung Song1, Won-Jung Shin1,*
1 Department of Anesthesiology and Pain Medicine, Laboratory for Cardiovascular Dynamics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 05505, Korea
2 Department of Physician Education and Training, Asan Medical Center, Seoul, 05505, Korea
* Corresponding Author: Won-Jung Shin. Email:
Congenital Heart Disease 2023, 18(6), 639-647. https://doi.org/10.32604/chd.2023.030065
Received 21 March 2023; Accepted 24 October 2023; Issue published 19 January 2024
Abstract
Objectives: We investigated whether the selective cerebral perfusion (SCP) technique causes differences in changes in cerebral perfusion between both hemispheres in young infants, using cerebral oxygen saturation (ScO
2) as an index. Further, we determined the association between the discrepancy in ScO
2 and cerebral perfusion pressure during SCP.
Methods: The difference in ScO
2 between the left and right cerebral hemispheres (ΔScO
2 Rt-Lt) was calculated during clamping of the innominate artery (IA) and during SCP.
Results: In 25 infants (aged 2 to 78 days), the left and right ScO
2 were well maintained (median 63.2% and 60.9% during IA clamping, respectively; 64.0% and 65.6% during SCP, respectively). During IA clamping, right and left ScO
2 decreased (median −1.4% and −1.0%, respectively). During SCP, right ΔScO
2 was higher compared to left ΔScO
2 (median 1.5%
vs. 0.6%;
p < 0.001). Eight patients had a higher right ΔScO
2 than left ΔScO
2 throughout SCP. They had lower ΔScO
2 Rt-Lt during IA clamping (median −3.2%
vs. 0.0%;
p < 0.001) and higher ΔScO
2 Rt-Lt during SCP than others (median 5.0%
vs. −0.8%;
p < 0.001). During and after SCP, the correlation coefficient between right ΔScO
2 and change in the mean arterial pressure was higher in patients with a discrepancy than in others (r = 0.731
vs. r = 0.519;
p < 0.001).
Conclusions: This study suggests that SCP permits adequate bilateral cerebral perfusion. However, the unilateral cerebral perfusion technique may cause a difference in cerebral perfusion between both hemispheres in young infants; this may depend on the perfusion pressure.
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APA Style
Jang, H., Beon, S., Kim, S., Song, I., Shin, W. (2023). Dynamic changes in left and right cerebral oxygen saturation during selective cerebral perfusion in young infants. Congenital Heart Disease, 18(6), 639-647. https://doi.org/10.32604/chd.2023.030065
Vancouver Style
Jang H, Beon S, Kim S, Song I, Shin W. Dynamic changes in left and right cerebral oxygen saturation during selective cerebral perfusion in young infants. Congeni Heart Dis. 2023;18(6):639-647 https://doi.org/10.32604/chd.2023.030065
IEEE Style
H. Jang, S. Beon, S. Kim, I. Song, and W. Shin "Dynamic Changes in Left and Right Cerebral Oxygen Saturation during Selective Cerebral Perfusion in Young Infants," Congeni. Heart Dis., vol. 18, no. 6, pp. 639-647. 2023. https://doi.org/10.32604/chd.2023.030065