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ARTICLE

Xuming Mo^1,*, Wei Cai^2,*, Jirong Qi¹, Zhuoming Xu³, Ying Wang⁴, Weihui Yan⁴, Shoujun Li⁵, Nianguo Dong⁶, Xinxin Chen⁷, Jinfen Liu³, Qiang Shu⁸, Jimei Chen⁹, Haibo Zhang³, Hao Zhang¹⁰, Quansheng Xing¹¹, Qi An¹², Xiaofeng Li¹³, Xu Wang¹⁴, Yan He¹⁵, Junwu Su¹⁶, Taibing Fan¹⁷, Teng Ming¹⁸, Weibing Tang¹⁹, Li Hong²⁰, Jinghao Zheng³, Ming Ye²¹, Guocheng Sun²², Yiqun Ding²³, Liang Tao²⁴, Yifeng Yang²⁵, Zhongshi Wu²⁵, Hua Cao²⁶, Qiang Wang¹⁶, Keming Yang⁵, Libing Zhang²⁷, Ping Wen²⁸, Yanqin Cui²⁹, Bo Zhai³⁰, Yong Zou¹⁸, Qingya Tang³¹, Rui Chen¹¹, Chun Wu³², Zhiyu Feng³³, Caixia Liu³⁴, Yaping Mi²¹, Rufang Zhang³⁵, Ke Lin¹², Xin Li³⁶, Mingan Pi³⁷, Xiangming Fan⁸, Shanshan Shi³⁸, Peng Huang³⁹, Zhengxia Pan³², Jiafeng Qi⁴⁰, Renwei Chen⁴¹, Shuguang Tao⁴², Yaqin Shu¹, Huifeng Zhang²¹, Lan Jiang¹, Min Da¹, Nishant Patel¹, Liang Hu¹, Cardiac Surgery Group of Pediatric Surgery Society of Chinese Medical Association, Parenteral Enteral Nutrition Society of Chinese Medical Association
Congenital Heart Disease, Vol.18, No.6, pp. 571-593, 2023, DOI:10.32604/chd.2024.048939 - 19 January 2024
Abstract The second edition of the expert consensus on pediatric nutrition was formed based on a global update of pediatric nutrition guidelines or consensus worldwide, the management of congenital heart disease, and the results of multi-center clinical nutrition research for congenital heart disease following the first Chinese consensus edition of 2016. The consensus was also shaped by the results of three discussion sessions and two questionnaires conducted by the 13-member collaboration group. This process was informed by both clinical guidelines and expert consensus. The quality of literature, both in English and Chinese, and the level of More >

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REVIEW

Pier Paolo Bassareo^1,2,3,*, Aurelio Secinaro⁴, Paolo Ciliberti⁵, Massimo Chessa^6,7, Marco Alfonso Perrone^5,8, Kevin Patrick Walsh^1,2,3, Colin Joseph Mcmahon^2,3
Congenital Heart Disease, Vol.18, No.6, pp. 595-610, 2023, DOI:10.32604/chd.2023.046229 - 19 January 2024
Abstract Background: Congenital absence of pericardium (CAP), also known as pericardial agenesis, represents an uncommon cardiac abnormality and mostly incidental finding. It can be subdivided into complete and partial (left or right-sided) forms. Because of its infrequency, just case reports and a few case series have been released so far. This paper represents the largest systematic review in the field. Nine features (age at diagnosis, type, gender, clinical presentation, electrocardiography, imaging (ultrasounds, CT/MRI), concomitant cardiac defects, and outcome) were analysed. Methods: The electronic database PubMed was investigated from its establishment up to July 15^th, 2023. Just case… More >

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ARTICLE

Aisa Zulibiya^1,2,#, Jing Wen^3,#, Huiqing Yu^3,#, Xiaoming Chen³, Lei Xu³, Xiao Ma^1,2, Baojian Zhang^1,2,*
Congenital Heart Disease, Vol.18, No.6, pp. 611-625, 2023, DOI:10.32604/chd.2023.047689 - 19 January 2024
Abstract Background: Tetralogy of Fallot (TOF) is a very common cyanotic congenital heart disease. Endothelial-to-mesenchymal transition (EndoMT) is recognized as a physiological mechanism involved in embryonic heart development and endothelial formation. However, there is still a gap in the reports related to the mechanism of EndoMT development in TOF. Methods: First, transcriptomic data of single cell nuclei of TOF and Donor were obtained based on the Gene Expression Omnibus (GEO) database, and the data were normalized and clustered by dimensionality reduction using the Seurat package. Subsequently, differentially expressed genes (DEGs) between TOF and Donor were screened… More >

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ARTICLE

Elisa Listo^1,#, Nicola Martini^2,#, Stefano Salvadori³, Elisa Valenti³, Nicola Stagnaro¹, Gianluca Trocchio⁴, Chiara Marrone⁵, Alberto Clemente⁶, Francesca Raimondi^7,*, Pierluigi Festa⁵, Lamia Ait Ali^5,8,*
Congenital Heart Disease, Vol.18, No.6, pp. 627-638, 2023, DOI:10.32604/chd.2023.030312 - 19 January 2024
Abstract Background: The assessment of Fontan circuit’s flow is traditionally evaluated by multiple through-plane phase-contrast MRI acquisitions (2D flow), while recently, a single volumetric 4D-flow MRI acquisition is emerging as a comprehensive tool for the hemodynamic evaluation in congenital heart diseases. Purpose: To compare 2D and 4D-flow MRI measurements in patients after Fontan palliation and to evaluate parameters affecting potential disagreement. Methods: 39 patients after Fontan palliation (23 males, age 22 ± 11 years) who underwent cardiac MRI with 2D and 4D-flow MRI acquisition were included in the study. In all patients, blood flow quantification in the… More >

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ARTICLE

Hwa-Young Jang¹, Sang-Jun Beon², Sung-Hoon Kim¹, In-Kyung Song¹, Won-Jung Shin^1,*
Congenital Heart Disease, Vol.18, No.6, pp. 639-647, 2023, DOI:10.32604/chd.2023.030065 - 19 January 2024
Abstract Objectives: We investigated whether the selective cerebral perfusion (SCP) technique causes differences in changes in cerebral perfusion between both hemispheres in young infants, using cerebral oxygen saturation (ScO₂) as an index. Further, we determined the association between the discrepancy in ScO₂ and cerebral perfusion pressure during SCP. Methods: The difference in ScO₂ between the left and right cerebral hemispheres (ΔScO_{2 Rt-Lt}) was calculated during clamping of the innominate artery (IA) and during SCP. Results: In 25 infants (aged 2 to 78 days), the left and right ScO₂ were well maintained (median 63.2% and 60.9% during IA clamping, respectively; 64.0%… More >

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CASE REPORT

Gustavo Foronda^1,2, Vanessa Ferreira Amorim de Melo^2,3,*, Claudia Regina Pinheiro de Castro Grau⁴, Ingrid Magatti Piva¹, Glaucia Maria Penha Tavares⁴, Ana Cristina Sayuri Tanaka¹, Nana Miura¹
Congenital Heart Disease, Vol.18, No.6, pp. 649-656, 2023, DOI:10.32604/chd.2023.027987 - 19 January 2024
Abstract Background: Children with congenital heart disease (CHD), even after surgical approaches, and especially those who undergo staged procedures in the first months of life, remain vulnerable to readmissions and complications, requiring very close monitoring and differentiated intervention strategies. Methods: Descriptive and exploratory study, of the experience report type, which presents the process of building the high-risk outpatient clinic for complex congenital heart diseases (AAR) at the Instituto do Coração (InCor). Results: Report of the path taken to structure the AAR, demonstrating the organization, interface with the multidisciplinary team, admission and discharge criteria, training, and patient profile.… More >

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ARTICLE

Kristi K. Westphaln^1,2,*, Karen Kay Imagawa^2,3, Lorena Espinosa Smith^1,4, Julia Srivastava⁵, Nancy A. Pike^1,5
Congenital Heart Disease, Vol.18, No.6, pp. 657-670, 2023, DOI:10.32604/chd.2023.044179 - 19 January 2024
Abstract Background: Congenital heart disease (CHD) is a chronic medical condition often diagnosed at birth and requires surgical intervention, multiple hospitalizations, and lifelong care. This can put significant stress on the family, leading to altered maternal mental health, bonding and attachment issues, and the potential for child abuse. The purpose of this study is to explore the characteristics of a sample of young children with CHD who experienced hospitalization with concurrent concern for child abuse in a free-standing pediatric tertiary care hospital. Methods: Electronic medical records were reviewed for children aged 0–5 years old who were… More >

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CASE REPORT

Dian Kesumarini^1,2, Yunita Widyastuti³, Cindy Elfira Boom¹, Lucia Kris Dinarti^4,*
Congenital Heart Disease, Vol.18, No.6, pp. 671-678, 2023, DOI:10.32604/chd.2023.044746 - 19 January 2024
Abstract Tetralogy of Fallot (TOF) with total anomalous pulmonary vein connections (TAPVC) is a rare type of complex congenital heart disease among all TOF cases. Co-presentation of major aortopulmonary collateral arteries (MAPCAs) compensates for the lack of central pulmonary blood flow and decreases the severity of right-to-left shunting in TOF. We present a case of a 2-year-old child with complex diagnoses of TOF, TAPVC, a large secundum atrial septal defect (ASD), and intraoperatively identified MAPCAs. She underwent surgery to repair the TAPVC, valve-sparing reconstruction of the right ventricular outflow tract, interventricular defect closure, and the creation… More >

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ARTICLE

Amr Mansour¹, Noha M. Gamal^2,*, Alaa M. Nady³, Amr Ibraheem³, Dalia M. Salah⁴, Khaled M. El-Maghraby²
Congenital Heart Disease, Vol.18, No.6, pp. 679-691, 2023, DOI:10.32604/chd.2023.020028 - 19 January 2024
Abstract Background: Closure of an atrial septal defect (ASD) reduces right-side heart volumes by abolishing shunting with simultaneous improvement of the left ventricle (LV) filling and functions due to ventricular interdependence, thereby improving symptoms. Furthermore, studies conducted on atrial volume changes after ASD closure are limited. Cardiac magnetic resonance (CMR) is considered as the gold standard method for measuring cardiac volume and mass. Objective: We aimed to study the effect of transcatheter and surgical closure of secundum ASD on cardiac volumes and systolic functions as well as the fate of tricuspid regurgitation (TR), using CMR analysis. Methods:… More >

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ARTICLE

Ziguang Song^1,2, Jiangbo Yu¹, Mengmeng Wang³, Weitao Shen⁴, Chengcheng Wang¹, Tianyi Lu¹, Gaojun Shan¹, Guo Dong¹, Yiru Wang¹, Jiyi Zhao^1,*
Congenital Heart Disease, Vol.18, No.6, pp. 693-701, 2023, DOI:10.32604/chd.2024.048081 - 19 January 2024
Abstract CHDTEPDB (URL: ) is a manually integrated database for congenital heart disease (CHD) that stores the expression profiling data of CHD derived from published papers, aiming to provide rich resources for investigating a deeper correlation between human CHD and aberrant transcriptome expression. The development of human diseases involves important regulatory roles of RNAs, and expression profiling data can reflect the underlying etiology of inherited diseases. Hence, collecting and compiling expression profiling data is of critical significance for a comprehensive understanding of the mechanisms and functions that underpin genetic diseases. CHDTEPDB stores the expression profiles of… More >

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