Open Access
ARTICLE
Alberto Cresti, Stefania Sparla, Stefania Stefanelli, Andrea Picchi*, Ugo Limbruno
Congenital Heart Disease, Vol.18, No.1, pp. 1-6, 2023, DOI:10.32604/chd.2023.025639
Abstract Background: Ventricular crypts are quite a common finding during cardiac imaging, but their etiology is unclear. A possible final result of a spontaneous ventricular septal defect closure has been supposed but never investigated in earlier studies. Method: From January 1997 to December 2020, all newborns diagnosed to have a ventricular septal defect were prospectively entered in our database and those with an isolated defect were included in the study. Ventricular septal defects were classified into four types: perimembranous, trabecular muscular, inlet and outlet. A long-term follow up was performed in order to visualize the possible residual formation of a septal… More >
Graphic Abstract
Open Access
ARTICLE
Ji-Yang Zuo1,2, Huan-Xin Chen1,2, Zhi-Gang Liu1,2, Qin Yang1,2, Guo-Wei He1,2,*
Congenital Heart Disease, Vol.18, No.1, pp. 7-21, 2023, DOI:10.32604/chd.2022.025451
Abstract Background: Atrial septal defect (ASD) is one of the common congenital heart diseases. The MYH6 gene has a
critical role in cardiac development but the role of MYH6 promoter variants in patients with ASD has not been
explored. Methods: In 613 subjects including 320 ASD patients, we investigated the MYH6 gene promoter variants and verified the effect on gene expression by using cellular functional experiments and bioinformatics analysis. Results: Eleven variants were identified in the MYH6 gene promoter, of which four variants were found only
in ASD patients, and two variants (g.3434G>C and g.4524C>T) were identified for the first time.… More >
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Open Access
ARTICLE
Laortip Rattanapittayaporn, Maliwan Oofuvong*, Jutarat Tanasansuttiporn, Thavat Chanchayanon
Congenital Heart Disease, Vol.18, No.1, pp. 23-39, 2023, DOI:10.32604/chd.2023.026026
Abstract Background: Prolonged preoperative fasting can cause hypoglycemia, hyperglycemia, and intravascular volume depletion in children. We aimed to examine whether prolonged preoperative fasting is associated with in-hospital mortality and other morbidities in pediatric cardiothoracic surgery. Methods: This retrospective cohort study included children aged 0–3 years who underwent cardiac surgery between July 2014 and October 2020. The patient demographic data, surgery-related and anesthesia-related factors, and postoperative outcomes, including hypoglycemia, hyperglycemia, sepsis, length of intensive care unit stay, and in-hospital mortality, were recorded. The main exposure and outcome variables were prolonged fasting and time-to-death after surgery, respectively. The associations between prolonged fasting and… More >
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Open Access
ARTICLE
Jinlong Liu1,2,#, Jing Shi3,#, Weiru Luo1, Zhirong Tong1,2, Lefei Yang3, Peixuan Sun3, Tianyi Li3, Jun Du3,*, Qian Wang3,*
Congenital Heart Disease, Vol.18, No.1, pp. 41-55, 2023, DOI:10.32604/chd.2023.025005
Abstract Background: The assessment of renal function is important to the prognosis of patients needing Fontan palliation due to the reconstructed compromised circulation. To know the relationship between the kidney perfusion and hemodynamic characteristics during surgical design could reduce the risk of acute kidney injury (AKI) and the postoperative complications. However, the issue is still unsolved because the current clinical evaluation methods are unable to predict the hemodynamic changes in renal artery (RA). Methods: We reconstructed a three-dimensional (3D) vascular model of a patient requiring Fontan palliation. The technique of computational fluid dynamics (CFD) was utilized to explore the changes of… More >
Graphic Abstract
Open Access
CASE REPORT
Vitaliy Suvorov*, Vladimir Zaitsev, Nikolay Pilyugov, Olga Tereshenko, Michail Komissarov
Congenital Heart Disease, Vol.18, No.1, pp. 57-65, 2023, DOI:10.32604/chd.2023.025522
（This article belongs to this Special Issue: Nightmare Case Reports in Congenital Heart Disease)
Abstract Critical aortic valve stenosis in newborns is the cause of a severe clinical condition with the onset of symptoms during first hours after birth. We present a clinical case of a successful surgical correction of a critical aortic stenosis using a hybrid method applied in a newborn during the first day of life. The infant was diagnosed with a hypoplastic left heart complex with an intact atrial septum (aortic and mitral valves stenosis variant), that led to the cardiogenic shock and acute pulmonary edema. The procedure included bilateral banding of the pulmonary artery branches and atrioseptostomy with stenting of the… More >
Graphic Abstract
Open Access
CASE REPORT
Andrei George Iosifescu1,2,*, Roxana Enache1,3, Ioana Marinică4, Corina Radu2, Vlad Anton Iliescu1,2
Congenital Heart Disease, Vol.18, No.1, pp. 67-72, 2023, DOI:10.32604/chd.2023.026598
（This article belongs to this Special Issue: Nightmare Case Reports in Congenital Heart Disease)
Abstract Left main coronary compression syndrome (LMCS) may complicate pulmonary artery aneurysms (PAA), usually developed in the context of pulmonary arterial hypertension (PAH). We report the case of a 51-year-old female patient with an atrial septal defect (unsuitable for device closure) complicated by a PAA generating a 90% left main stenosis. The significant PAH held us back from immediate surgery. After specific dual PAH-targeted therapy (sildenafil and bosentan), the atrial septal defect could be closed with a unidirectional valved patch; the PAA-induced LMCS was treated by reductive arterioplasty. The postoperative course was uneventful. Follow-up showed clinical improvement, but PAH treatment was… More >
Graphic Abstract
Open Access
CASE REPORT
Weimin Zhang, Zheng Liu, Tao Zhu, Qiang Huo*
Congenital Heart Disease, Vol.18, No.1, pp. 73-78, 2023, DOI:10.32604/chd.2023.026404
（This article belongs to this Special Issue: Nightmare Case Reports in Congenital Heart Disease)
Abstract Pentalogy of Cantrell is a congenital anomaly characterized by a combination of birth defects involving the sternum, diaphragm, pericardium, abdominal wall, and heart. Pentalogy of Cantrell is a rare anomaly with high mortality. This paper describes the treatment of a 9-month-old girl with pentalogy of Cantrell, pentalogy of Fallot, and left ventricular diverticulum. The patient is alive and well 13 years after surgery. More >
Open Access
ARTICLE
Daniel Quandt1,4,5,#,*, Alessia Callegari1,4,5,#, Oliver Niesse1,4,5, Martin Christmann1,4,5, Anke Meinhold2,4,5, Hitendu Dave3,4,5, Walter Knirsch1,4,5, Oliver Kretschmar1,4,5
Congenital Heart Disease, Vol.18, No.1, pp. 79-95, 2023, DOI:10.32604/chd.2022.022401
Abstract Background: This study set out to assess the indications, feasibility, safety, and outcome of early cardiac catheterizations (CC) within 30 days after congenital heart surgery (CHS) in children. Methods and Results: This is a
retrospective, single-center case review study of all CC within 30 days after CHS between 1/2010-12/2020. A total
of 317 (138 diagnostic, 179 interventional) CC were performed in 245 patients at a median of 4 days (IQR 13)
after CHS. The median age was 3 months (IQR 6), and body weight was 5 kg (IQR 4). A total of 194 (61.2%) CC
were performed in patients with… More >
Open Access
ARTICLE
Lilia Oreto1,*, Giuseppe Mandraffino2, Paolo Ciliberti3, Teresa P. Santangelo4, Placido Romeo5, Antonio Celona5, Placido Gitto1, Lorenzo Galletti3, Fiore S. Iorio3, Alfredo Di Pino1, Aurelio Secinaro4, Paolo Guccione3, Robert H. Anderson6, Salvatore Agati1
Congenital Heart Disease, Vol.18, No.1, pp. 97-111, 2023, DOI:10.32604/chd.2022.023619
Abstract Aims: Evidence is emerging that, in the setting of isomerism, the atrial and bronchial arrangement are not always concordant, nor are these patterns always harmonious with the arrangement of the abdominal organs. We aimed to evaluate the concordance between these features in a cohort of patients with cardiac malformations in the setting of known isomerism, seeking to determine whether it was feasible to assess complexity on this basis, in this regard taking note of the potential value of bronchial as opposed to appendage morphology. Methods and Results: We studied 78 patients known to have isomerism of the bronchuses, 43 with… More >
Graphic Abstract
Open Access
ARTICLE
Wenlei Qian1,#, Xinzhu Zhou2,#, Ke Shi1, Li Jiang1, Xi Liu3, Liting Shen1, Zhigang Yang1,*
Congenital Heart Disease, Vol.18, No.1, pp. 113-125, 2023, DOI:10.32604/chd.2023.023542
Abstract Background: Pulmonary atresia (PA) is a group of heterogeneous complex congenital heart disease. Only one study modality might not get a correct diagnosis. This study aims to investigate the diagnostic power of dual-source computed tomography (DSCT) for all intracardiac and extracardiac deformities in patients with PA compared with transthoracic echocardiography (TTE). Materials and Methods: This retrospective study enrolled 79 patients and divided them into three groups according to their main diagnosis. All associated malformations and clinical information, including treatments, were recorded and compared among the three groups. The diagnostic power of DSCT and TTE on all associated malformations were compared.… More >
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