TY - EJOU AU - Zhou, Huan AU - Kang, Jin AU - Gao, Jun AU - Feng, Xiaoyuan AU - Zhou, Li AU - Xiao, Xia AU - Meng, Zhengliang AU - Guo, Chengwen TI - Evaluation of Biventricular Volume and Systolic Function in Children with Ventricular Septal Defect and Moderate to Severe Pulmonary Hypertension Using Real-Time Three-Dimensional Echocardiography T2 - Congenital Heart Disease PY - 2022 VL - 17 IS - 6 SN - 1747-0803 AB - Background: Real-time three-dimensional echocardiography (RT-3DE) could obtain ventricular volume and ejection fraction rapidly and non-invasively without relying on ventricular morphology. This study aims to use RT-3DE to evaluate the changes in biventricular volume and systolic function in children with ventricular septal defect (VSD) and moderate to severe pulmonary hypertension (PH) before surgery. Methods: In this study 18 children with VSD and moderate to severe PH (VSD + PH Group) and 18 healthy children of the same age (Control Group) were recruited. Biventricular volume and systolic function were evaluated by RT-3DE. The measurements included: left and right ventricular volume indexed to body surface area (BSA), stroke volume (SV) indexed to BSA, and ejection fraction (EF). Results: The results showed left and right ventricular volume indexed to BSA and SV indexed to BSA were significantly increased in VSD + PH Group (VSD + PH Group vs. Control Group), LVEDV/BSA (ml/m2 ): 48.67 ± 21.46 vs. 25.59 ± 6.96, RVEDV/BSA (ml/m2 ): 55.98 ± 15.35 vs. 27.69 ± 4.37, LVSV/BSA (ml/m2 ): 24.08 ± 9.30 vs. 15.14 ± 4.29, RVSV/BSA (ml/m2 ): 26.02 ± 8.87 vs. 14.11 ± 2.89, (P < 0.05). While for EF in VSD + PH Group decreased (VSD + PH Group vs. Control Group), LVEF: 50.93 ± 7.50% vs. 59.38 ± 7.24%, RVEF: 45.84 ± 7.71% vs. 51.05 ± 6.90% (P < 0.05). Conclusion: In children with VSD and moderate to severe PH, increased biventricular volume and decreased systolic function were observed with RT-3DE, but biventricular systolic function remained within acceptable limits. The children in this study recovered well after surgery without serious perioperative complications, suggesting that biventricular systolic function may help facilitate the surgical decision-making process in children with VSD and moderate-tosevere PH. KW - Real-time three-dimensional echocardiography; ventricular septal defect; pulmonary hypertension; children DO - 10.32604/chd.2022.022648