Open Access
ARTICLE
Modification of Serum Galectin-3 and Reversal of Cardiac Remodeling Following Pediatric Transcatheter Atrial Septal Defect Closure
Omnia Shafei1,2,*, Alyaa A. Kotby1,2, Mona M. El Ganzoury1,2, Nevin M. Habeeb1,2, Eman Elsayed1,2
1
Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt
2
Children’s Hospital, Cardiology Unit, Ain Shams University Hospitals, Cairo, Egypt
* Corresponding Author: Omnia Shafei. Email:
Congenital Heart Disease 2022, 17(2), 173-185. https://doi.org/10.32604/CHD.2021.016987
Received 17 April 2021; Accepted 30 June 2021; Issue published 26 January 2022
Abstract
Objectives: We aimed to evaluate the effect of percutaneous atrial septal defect (ASD) closure in children using
right heart indices and serum galectin-3 (Gal-3), as potential biomarkers of right heart remodeling.
Methods: This
case–control prospective study included 40 children with ASD and 25 control subjects. An echocardiographic evaluation was performed before the procedure, as well as 24 h, 1 month, and 6 months after intervention. Serum
Gal-3 was measured before, and 1 month after the procedure.
Results: Serum Gal-3 concentration, right atrial
(RA) dimensions, right ventricular (RV) dimensions, indexed RA area, and right index of myocardial
performance (RIMP) were significantly increased in children with ASD compared with control subjects while tricuspid annular plane systolic excursion (TAPSE) was significantly decreased. Six months after closure, RA, and
RV dimensions significantly decreased and RV function improved (RIMP decreased and TAPSE increased). Gal-3
oncentration significantly decreased 1 month after ASD closure, but it did not reach normal range compared with
control subjects. A positive correlation between Gal-3 and age at closure, RA area, RV dimensions, and RIMP was
observed. A positive correlation was observed between the decrease in Gal-3 concentration and the decrease in
RA area and RV dimensions 1 month after ASD closure. A significant negative correlation was observed between
TAPSE and Gal-3 concentration before and after intervention.
Conclusions: Percutaneous ASD closure can
improve right-sided indices and decrease serum Gal-3 concentration. Gal-3 can be used as a sensitive biomarker
of right heart remodeling, with a decrease in Gal-3 concentration suggesting reversal of maladaptive remodeling.
Keywords
Cite This Article
Shafei, O., Kotby, A. A., M., M., Habeeb, N. M., Elsayed, E. (2022). Modification of Serum Galectin-3 and Reversal of Cardiac Remodeling Following Pediatric Transcatheter Atrial Septal Defect Closure.
Congenital Heart Disease, 17(2), 173–185.