Open Access
GUIDELINE
Gabriele Egidy Assenza1, Biagio Castaldi2,*, Serena Flocco3, Giovanni Battista Luciani4, Giovanni Meliota5, Gabriele Rinelli6, Ugo Vairo5, Silvia Favilli7, Board of the Italian Society of Pediatric Cardiology
Congenital Heart Disease, Vol.16, No.5, pp. 427-431, 2021, DOI:10.32604/CHD.2021.016713
Abstract COVID-19 pandemic continues to strike across the world with increasing number of infected patients, severe
morbidity and mortality, social life and economy disruption. Universal access to vaccine prophylaxis will be pivotal in controlling this infection and providing individual level protection. However, mismatch between vaccine
request and vaccine availability, as well as constraints in logistics of vaccine campaign is creating a transition
phase of progressive but still incomplete inclusion of group of individuals in the vaccination process. Selected
patients living with chronic and multisystemic disease may present increased propensity of adverse outcome,
should Sars-Cov-2 infection develop. In these patients, expedite access… More >
Open Access
ARTICLE
Siraphop Thapmongkol1,*, Jarun Sayasathid1, Jessada Methrujpanont2, Kanthachat Thatsakorn1, Worawan Jittham3, Suwanna Puitm4, Methiniwiran Thapmongkol5, Jule Namchaisiri6
Congenital Heart Disease, Vol.16, No.5, pp. 433-441, 2021, DOI:10.32604/CHD.2021.015770
Abstract Background: The surgical outcomes of tetralogy of Fallot (TOF) have evolved dramatically and have resulted in
lower mortality rate. Currently, the many cardiac centers have a trend to early single-stage complete repair more
than a staged repair. However, the patients who have an early primary repair were required transannular patch
augmentation of a pulmonary valve frequently. This effect has been developed a chronic pulmonary insufficiency
may lead to right ventricular dilation, dysfunction. In this era, the aim of treatment of TOF is attempted to preserve pulmonary valve annulus for prevent right ventricular dysfunction in the future. The systemic to pulmonary… More >
Open Access
ARTICLE
Hong Liu1,#,*, Luyao Ma1,#, Jinghang Li1,#, Bingqi Sun2, Siqiang Zheng3, Yongfeng Shao1,*
Congenital Heart Disease, Vol.16, No.5, pp. 443-455, 2021, DOI:10.32604/CHD.2021.015588
Abstract Background: This study evaluated differential inflammatory response to cardiopulmonary bypass reoxygenation in
tetralogy of Fallot repair. Methods: We performed a retrospective study at a cardiovascular center from 2012 to
2018, including 500 patients aged 1 week–18 years who received complete repair of tetralogy of Fallot. Patients were
grouped according to tertiles of preoperative RVOT gradient on echocardiography into mild, moderate, and severe
stenosis. We measured the highest perfusate oxygenation (PpO2) during aortic occlusion as independent variable.
Primary outcome was systemic inflammatory response syndrome (SIRS) within 7 days postoperatively or the time of
death or discharge. Results: Overall, rate of SIRS… More >
Open Access
ARTICLE
Marie Laure Yammine#,*, Camilla Calvieri#, Marcello Chinali, Salvatore Giannico, Giulia Cafiero, Ugo Giordano
Congenital Heart Disease, Vol.16, No.5, pp. 457-467, 2021, DOI:10.32604/CHD.2021.015896
Abstract Background: In recent decades, aortic stenting has become a promising alternative to surgery for both native aortic coarctation and re-stenosis in children and adults. However, comparative long-term outcomes have poorly
been investigated. Methods: We included 212 patients with previous aortic repair (19 ± 8.7 years) divided
into 3 groups: 139 with single-time surgical repair (CoA-S group); 18 with single-time percutaneous stenting
(CoA-PS group); and 55 hybrid patients with multiple aortic procedures because of re-coarctation occurrence
(CoA-H group). All patients underwent 24-hour ambulatory blood pressure monitoring and trans-thoracic echocardiography. Results: After a median follow-up of 17 years after aortic repair, antihypertensive… More >
Open Access
CASE REPORT
Jadranka Separovic Hanzevacki1, Marija Brestovac1,*, Vlatka Reskovic Luksic1, Blanka Glavas Konja1, Martina Lovric Bencic1, Josko Bulum1, Darko Anic2
Congenital Heart Disease, Vol.16, No.5, pp. 469-475, 2021, DOI:10.32604/CHD.2021.015237
Abstract Patients with complete transposition of the great arteries (TGA) treated by the Senning procedure have a higher risk of developing heart failure due to: a) additional work load of the systemic (morphologic right) ventricle (sRV), b) arrhythmias, mainly caused by surgical implications at the atria as well as c) worsening of systemic tricuspid regurgitation. We present a unique case of a female patient who developed all these complications, who was successfully treated and was able to carry out a twin pregnancy. This breakthrough approach was based on: 1. detecting reversibility potential of myocardial systolic dysfunction in a severe valvular lesion… More >
Open Access
ARTICLE
Ju Wang, Shuo Dong, Jun Yan*
Congenital Heart Disease, Vol.16, No.5, pp. 477-485, 2021, DOI:10.32604/CHD.2021.015016
Abstract Objective: Modifications of the Fontan operation, which are also known as total cavopulmonary connection
(TCPC), are widely applied for patients with functionally univentricular hearts (FUH). Herein, we summed up
the different surgical pathways and clinical outcomes in FUH patients with apicocaval juxtaposition (ACJ) or/and
separated hepatic venous (SHV) drainage. Methods: Between January 2009 and December 2019, 123 patients who
undergone TCPC in our institute were included in this retrospective study. We have included 70 patients with
ACJ (Group 1) and 53 patients with SHV (Group 2). Moreover, Group 2 included 17 cases combing with ACJ
(32.1%). In Group 1, three… More >
Open Access
ARTICLE
Muyu Qi1,#, Xiaoping Lan2,#, Jia Li1, Junwen Ge1, Li Shen1,*, Rufang Zhang1,*
Congenital Heart Disease, Vol.16, No.5, pp. 487-498, 2021, DOI:10.32604/CHD.2021.015887
Abstract Objective: Pulmonary atresia (PA) is a rare type of complex cyanotic congenital heart defect characterized primarily by an undeveloped pulmonary valve or pulmonary artery. Therefore, defining a disease-causing gene
mutation in a pulmonary atresia family is a possible method of genetic counseling, future prenatal diagnosis,
and therapeutic approaches for pulmonary atresia. Methods: Blood samples were collected from six PA family
members, and genomic DNA was extracted using the QIAamp DNA Blood Mini Kit. Gene detection was performed using a second-generation sequencing gene panel. Results: Genetic testing results indicated that a heterozygous mutation originating from maternal inheritance was detected in the… More >
Open Access
ARTICLE
Liying Gong1,2,3, Hongkun Jiang4, Guangrong Qiu1, Kailai Sun1,*
Congenital Heart Disease, Vol.16, No.5, pp. 499-512, 2021, DOI:10.32604/CHD.2021.015831
Abstract Background: microRNAs are crucial for cardiovascular development and are associated with congenital heart disease (CHD). Recent studies have shown that microRNAs play a role in heart development and is closely related to
CHD. The present study investigated the underlying mechanism of microRNA-208a (miR-208a) in “simple”
CHD. Material and Methods: Reverse transcription-quantitative PCR (RT-qPCR) demonstrated miR-208a
expression levels in children with CHD (n = 27) compared with normal controls (n = 29), in cardiomyocytes from
embryo 10 (E10) to post-birth (P7) and organs in adult rats in healthy rats. Apoptosis of H9c2 cells after transfection with miR-208a detected by TUNEL assay.… More >
Open Access
CASE REPORT
Hao Hong1, Nianguo Dong1,*, Mingxing Xie2, Lin Li2, Si Chen1, Wengang Sun3, Xiaoqing Hu2
Congenital Heart Disease, Vol.16, No.5, pp. 513-518, 2021, DOI:10.32604/CHD.2021.015749
Abstract Pentalogy of Cantrell is a rare congenital abnormality. Even with high-quality medical care and staged corrective surgeries in professional hospitals, the mortality rate is still very high and long-term prognosis is poor. Survival is largely determined by the complexity and severity of cardiac abnormalities, the efficiency of abdominal wall closure and postoperative complications. A 24-year-old male patient with complete pentalogy of Cantrell was diagnosed. One-stage surgical repair of all abnormalities were completed. The patient recovered well and had been follow-up for 7 years. He has a good cosmetic outcome, with no signs of cardiac dysfunction. No complications were noted. More >
Open Access
ARTICLE
Wenqian Zhang1,2,#, Chaojie Wang1,3,#, Lingmei Zhou2,4,#, Junjie Li2, Jijun Shi2, Yumei Xie2, Mingyang Qian2, Shushui Wang2, Zhiwei Zhang1,2,*
Congenital Heart Disease, Vol.16, No.5, pp. 519-528, 2021, DOI:10.32604/CHD.2021.015527
Abstract Objective: This study aims to evaluate the morphology and function of the aortic valve after transcatheter closure
of ventricular septal defect (VSD) with aortic valve prolapse (AVP) abased on clinical and radiological outcomes.
Methods: From January 2013 to November 2014, 164 consecutive patients (97 males, 59.1%) with VSD and AVP were
treated by transcatheter closure. The patients were divided into the mild AVP group (n = 63), moderate AVP group
(n = 89) and severe AVP group (n = 12). The clinical and radiological outcomes of these patients were analyzed retrospectively. Results: In total, 146 (89.0%) patients were successfully treated… More >
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