Home / Journals / CHD / Vol.16, No.3, 2021
  • Open Access

    ARTICLE

    Use of the GORE® DrySeal Flex Introducer Sheath to Facilitate Implantation of the Transcatheter Venus P-valve

    Matthew I. Jones1, Matthew Murphy2, Eric Rosenthal1, Kevin P. Walsh2,3, Damien Kenny2,3, Shakeel A. Qureshi1, Gianfranco Butera1,4,*
    Congenital Heart Disease, Vol.16, No.3, pp. 197-203, 2021, DOI:10.32604/CHD.2021.015222
    Abstract Objectives: We report our experience of using the 65 cm large diameter GORE® DrySeal Flex Introducer sheath to facilitate transcatheter implantation of the Venus P-valve in the pulmonary position. Background: Transcatheter implantation of pulmonary valves can be difficult due to rigidity of the valve delivery system or the anatomy of the RVOT and pulmonary artery bifurcation and the risk of iatrogenic damage to the tricuspid valve support apparatus. Using long sheaths to pass and protect the tricuspid valve may facilitate the procedure. Methods: Multi-centre registry of patients who underwent transcatheter pulmonary valve implantation of the Venus P-valve using the GORE®More >

  • Open Access

    CASE REPORT

    Management of “Wall to Wall Heart” in a Transient Neonatal Tricuspid Regurgitation

    Elio Caruso*, Silvia Farruggio, Davide Calvaruso, David Fabio Petruccelli, David Angel Ortiz Ruiz, Corrado Di Mambro, Salvatore Agati
    Congenital Heart Disease, Vol.16, No.3, pp. 205-210, 2021, DOI:10.32604/CHD.2021.015371
    Abstract We present a case of a one-day-old newborn, without prenatal diagnosis, referred to our cardiologic intensive care unit in critical condition presenting sub-cyanosis and peripheral oxygen saturation of 80%. Echocardiography diagnosis was tricuspid valve dysplasia with severe regurgitation, functional pulmonary valve atresia with intact ventricular septum and reversal flow in the large patent ductus arteriosus (PDA). Chest X-ray showed severe cardiomegaly and wall to wall heart. Prostaglandin E1 infusion was started once after birth. After few days, clinical conditions progressively worsened because of right heart failure; a first pharmacological approach to close PDA failed and surgery ligation of PDA was… More >

  • Open Access

    ARTICLE

    Changes in Reverse Cardiac Remodeling after Percutaneous Atrial Septal Defect Closure in Children and Adults

    Geena Kim1, Hong Ryang Kil2,*
    Congenital Heart Disease, Vol.16, No.3, pp. 211-220, 2021, DOI:10.32604/CHD.2021.013724
    Abstract Background: The influence of the timing of transcatheter atrial septal defect (ASD) closure on ventricular remodeling at 6 months after ASD closure is unclear. This study investigated changes in cardiac remodeling after transcatheter closure of large ASDs according to patient age at the time of the procedure. Methods: In this study, 41 children and 43 adults underwent percutaneous closure of a large ASD. Cardiac remodeling was assessed by two-dimensional echocardiography and electrocardiography before and at 6 months after ASD closure. Results: The age of the children and adults were 2.8 ± 3.1 and 50.0 ± 15.6 years, respectively. The Qp/Qs… More >

  • Open Access

    ARTICLE

    The Prognostic Value of Myocardial Deformation in Patients with Congenital Aortic Stenosis

    Roderick W. J. van Grootel, Allard T. van den Hoven, Dan Bowen, Tijmen Ris, Jolien W. Roos-Hesselink, Annemien E. van den Bosch*
    Congenital Heart Disease, Vol.16, No.3, pp. 221-232, 2021, DOI:10.32604/CHD.2021.013793
    Abstract Aims: To assess the prognostic value of left ventricular (LV) global longitudinal strain (GLS) and global longitudinal early diastolic strain rate (GLSre) with regard to cardiovascular events, as congenital aortic stenosis (AoS) is associated with significant mortality and morbidity but predictors for clinical outcome are scarce. Strain analysis provides a robust and reproducible method for early detection of LV dysfunction, which might be of prognostic value. Methods: This prospective study, included clinically stable patients with congenital AoS between 2011–2013. LV GLS and GLSre was performed in the apical 4, 3 and 2-chamber views using Tomtec software. The endpoint was a… More >

  • Open Access

    ARTICLE

    Selexipag as Add-on Therapy for Patients with Pulmonary Arterial Hypertension Associated with Congenital Heart Disease: A Single-Center Retrospective Study

    Se Yong Jung#, Doyoung Jung#, Ah Young Kim, Jae Hee Seol, Jung Min Park, Jo Won Jung, Jae Young Choi*
    Congenital Heart Disease, Vol.16, No.3, pp. 233-244, 2021, DOI:10.32604/CHD.2021.014272
    Abstract Purpose: This study examined the efficacy and safety of selexipag in treating pulmonary arterial hypertension (PAH) associated with congenital heart disease (CHD). Materials and Methods: We conducted a retrospective study of patients with CHD-associated PAH, treated with selexipag since December 2017. Thirteen adult patients (mean age, 45.4 years; women, 77%) were treated with selexipag as add-on therapy. Baseline characteristics, World Health Organization functional class, 6-minute walking distance (6MWD) test results, N-terminal pro-B-type natriuretic peptide levels, echocardiographic data, and incidence of side effects were assessed. Results: The majority of patients (12/13, 92.3%) experienced more than one treatment-associated complication; one patient dropped… More >

  • Open Access

    ARTICLE

    A Novel Perspective on Histopathology Provides Novel Insights into Surgical Effects in Pulmonary Atresia, Ventricular Septal Defect, and Major Aortopulmonary Collateral Arteries: A Case-Series Study

    Jinyang Liu1, Xianchao Jiang1, Runsi Wang2, Li Li3, Ju Zhao4, Fuxia Yan5, Run Yuan6, Qiang Wang1,*
    Congenital Heart Disease, Vol.16, No.3, pp. 245-254, 2021, DOI:10.32604/CHD.2021.014881
    Abstract Background: Never had literatures characterized the relationship between the property of major aortopulmonary collateral arteries (MAPCAs) and outcomes of selective unifocalization of pulmonary atresia with ventricular septal defects and MAPCAs. Methods: This is a case-series study. Thirteen patients were included. Angiography-based assessment was conducted to determine whether collateral arteries should be unifocalized or treated with intraoperative ligature. Specimens were collected and stained by HE and ET+VG. Results: Twelve patients underwent one-stage unifocalization at a median age of 37 months (range: 6–228 months) and a median weight of 14.0 kg (range: 5.0–49.0 kg), which produced a favorable right ventricle to aortic… More >

  • Open Access

    ARTICLE

    Higher Child-Reported Internalizing and Parent-Reported Externalizing Behaviors were Associated with Decreased Quality of Life among Pediatric Cardiac Patients Independent of Diagnosis: A Cross-Sectional Mixed-Methods Assessment

    Jacqueline S. Lee1,2, Angelica Blais1,2, Julia Jackson1, Bhavika J. Patel1, Lillian Lai4, Gary Goldfield1,3, Renee Sananes5, Patricia E. Longmuir1,2,3,*
    Congenital Heart Disease, Vol.16, No.3, pp. 255-267, 2021, DOI:10.32604/CHD.2021.014628
    Abstract Background: Pediatric cardiology patients often experience decreased quality of life (QoL) and higher rates of mental illness, particularly with severe disease, but the relationship between them and comparisons across diagnostic groups are limited. This mixed-methods cross-sectional study assessed the association between QoL anxiety and behavior problems among children with structural heart disease, arrhythmia, or other cardiac diagnoses. Methods: Children (6–14 years, n = 76, 50% female) and their parents completed measures of QoL (PedsQL), behavior (BASC-2, subset of 19 children) and anxiety (MASC-2, children 8+ years). Pearson correlations/regression models examined associations between QoL, behavior and anxiety, controlling for age, sex,… More >

  • Open Access

    ARTICLE

    Efficacy and Safety of the Atrial Septal Defect Closure for Patients with Absent or Malaligned Aortic Rim Using a Figulla Flex II Device Flared and Straddling Behind the Aorta

    Masataka Kitano1,2,*, Kazuto Fujimoto1, Atsuko Kato1, Ken-ichi Kurosaki1, Isao Shiraishi1
    Congenital Heart Disease, Vol.16, No.3, pp. 269-283, 2021, DOI:10.32604/CHD.2021.015308
    Abstract Background: Although transcatheter closure of atrial septal defect (ASD) is safe and effective for patients with sufficient rim, ASD patients with absent and/or malaligned aortic and/or superior rim have higher risks of device embolization and cardiac erosion. We have treated such high-risk patients using a Figulla Flex II (FFII) device shaped flared and straddling behind the aorta because this method would avoid such serious complications. However, its long-term efficacy and safety remain unclear. Therefore, the midterm efficacy and safety of this method were studied. Methods: We retrospectively evaluated the outcome of 47 consecutive patients with such rim (age 6–73 years,… More >

  • Open Access

    ARTICLE

    A Systematic Approach to Pulmonary Valve Replacement in the Current Era

    R. Allen Ligon1,*, Larry A. Latson1, Mark M. Ruzmetov2, Kak-Chen Chan1, Todd Roth1, Immanuel I. Turner2, Frank G. Scholl2, Steve Bibevski2
    Congenital Heart Disease, Vol.16, No.3, pp. 285-297, 2021, DOI:10.32604/CHD.2021.014373
    Abstract Background: Pulmonary valve replacement (PVR) can be accomplished via surgical, transcatheter, or hybrid approaches. There are inherent advantages to transcatheter PVR and hybrid PVR without cardiopulmonary bypass. We review the methods and results of a standardized institutional approach to PVR. Methods: Retrospective review of all PVR cases between February 2017 and February 2020. Hybrid PVR entailed off-pump RVOT plication with percutaneous transcatheter PVR. Results: Primary transcatheter PVR was attempted in 37, hybrid PVR was performed in 11, and on-pump surgical PVR was performed in 9. Median age at PVR was 27 years (6–65). Primary transcatheter PVR was successful in 35/37… More >

  • Open Access

    ARTICLE

    Lesion-based Patterns of Morbidity and Mortality in Hospitalized Adolescents with Congenital Heart Disease

    Aparna Kulkarni1,*, Richard Neugebauer2, Shelby Kutty3
    Congenital Heart Disease, Vol.16, No.3, pp. 299-307, 2021, DOI:10.32604/CHD.2021.014495
    Abstract Objective: The objective of this analysis is to describe the characteristics and morbidity during hospitalizations among adolescents with congenital heart disease (AdoCHD) from the Pediatric Health Information System (PHIS) database. Methods: The PHIS database was queried for all AdoCHD admissions aged 12–18 years (1/1/2004–12/31/2013). Major forms of CHD were identified by their International Classification of Diseases, ninth revision codes, further verified based on their secondary diagnosis and/or procedure codes. Patient characteristics, diagnoses, procedures and vital status were assessed. Results: In total, there were 4,267 adolescents admitted to 42 Children’s Hospitals, 58.3% were males, 24.6% single ventricle (SV) patients, 64.1% bi-ventricle… More >

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